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The Synthesis, Application and Therapeutic Perspectives of Medicinal Plants-Based Solid Lipid Nanoparticles: A Comprehensive Review Publisher



Mottaqi M1 ; Langarizadeh MA2 ; Molaali N3 ; Rezaei M4 ; Ameri A2 ; Forootanfar H5
Authors
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Authors Affiliations
  1. 1. Program in Biochemistry, The Graduate Center of the City University of New York, New York, NY, United States
  2. 2. Department of Medicinal Chemistry, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran
  3. 3. International Campus, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran
  5. 5. Pharmaceutical Sciences and Cosmetic Products Research Center, Kerman University of Medical Sciences, Kerman, Iran

Source: Advances in Traditional Medicine Published:2025


Abstract

Lipid-based drug carriers have gained massive amounts of interest in the last two-decade period as a way to deliver drugs that are not particularly water-soluble. Pharmaceutical uses of lipid nanocarriers include carrying and administering a wide range of therapeutic ingredients. Solid lipid nanoparticles (SLNs) were designed and formulated to rise above the disadvantages of existing colloidal systems, including microemulsions, liposomes and polymeric nanoparticles, by offering benefits such as a favorable release profile and targeted medication distribution while having great physical integrity. We sought to evaluate the recent findings on the current issue to provide a comprehensive perspective of the subject utilizing an extensive literature search to pinpoint the latest scientific reports on this subject. The focus of this paper is on the research employing SLNs for delivery of medicinal plants and testing them in vitro and in vivo. There are a number various standard variables affecting the release of compounds from SLNs throughout all administration routes. Further, the current paper comprehensively elucidates assorted prospects of SLNs. Next, the investigated SLNs encapsulating herbal compounds in scientific articles are reviewed in details. As many herbal compounds are hydrophobic substances, the SLNs encapsulating them can be beneficial in various therapeutic applications. The most studies herbal compounds are Curcumin, followed by Silibinin and Artemisinin. © The Author(s), under exclusive licence to Institute of Korean Medicine, Kyung Hee University 2024.
1. Lipid-Based Nanoparticles for Drug Delivery Systems, Characterization and Biology of Nanomaterials for Drug Delivery: Nanoscience and Nanotechnology in Drug Delivery (2018)
3. A State-Of-The-Art Review on Solid Lipid Nanoparticles As a Nanovaccines Delivery System, Journal of Drug Delivery Science and Technology (2023)
8. Toxicity Concerns of Nanocarriers, Nanotechnology-Based Approaches for Targeting and Delivery of Drugs and Genes (2017)
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