Advances in Benzimidazole Coordination Chemistry: From Synthetic Innovations to Emerging Therapeutic Potentials Publisher



Ahmadfilab P¹ ; Pordel M² ; Kheirkhahnia S³ ; Ziaei S² Show Affiliations
Source: Journal of Molecular Structure Published:2025

Abstract

Over the past decade (2015–2025), benzimidazole-based metal complexes have garnered significant attention in coordination chemistry and biomedical research. This review presents a detailed evaluation of the latest progress in production methodologies, analytical profiling of molecular structures, and multifaceted preliminary biological assessments of these compounds. Innovative synthetic methodologies have enabled the development of novel ligands with enhanced stability and bioactivity. Benzimidazole-metal complexes exhibit diverse biological activities, including antimicrobial, antioxidant, anticancer, and enzyme-inhibitory effects, largely due to their interactions with biomolecules such as DNA and proteins. DNA binding assays have provided valuable insights into their therapeutic mechanisms, reinforcing their potential as drug candidates. Furthermore, integrating of experimental and computational approaches has deepened our understanding of their structure-activity relationships, paving the way for rational drug design. This review highlights the synergy between experimental techniques and computational modeling in advancing benzimidazole complex research. We aim to provide a foundation for future pharmaceutical and biomedical innovations by synthesizing recent developments in this rapidly evolving field. © 2025