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A Review on Zinc, Cadmium, and Mercury Complexes With Anticancer Activity Publisher



Saeedian Moghadam E1 ; Emamgholipour Z2 ; Foroumadi A1, 2 ; Amini M1, 2
Authors
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Authors Affiliations
  1. 1. Drug Design and Development Research Center, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, 1417614411, Iran

Source: Inorganic Chemistry Communications Published:2024


Abstract

Over the last few years, there has been a surge in interest surrounding the exploration of the therapeutic benefits of metal-based complexes because of their great potential in treating a variety of diseases, their unique roles in biological processes, and their ability to modulate a diverse range of molecular targets. cadmium (Cd), Zinc (Zn), and mercury (Hg), which belong to Group 12 (IIb) of the periodic table, exhibit potential anticancer properties by targeting specific cellular pathways that contribute to cancer progression. Numerous studies have demonstrated their selective antiproliferative effect in vitro and in vivo. Despite the increased interest in this field, a comprehensive review assessing the antitumor effects of elements belonging to the same group for designing new therapeutic derivatives is yet to be undertaken. Current review outlines the latest developments in the synthesis of Zn, Cd, and Hg complexes that exhibit promising potential as anticancer agents. we hope this review provides distinct insights into future studies of anticancer agents. © 2024
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