Micronization and Characterization of Ultrafine Pure and Composite Aspirin by Co2-Expanded Solution

Micronization and Characterization of Ultrafine Pure and Composite Aspirin by Co2-Expanded Solution Publisher

Rostamian H¹ ; Lotfollahi MN¹ ; Mohammadi A²

Show Affiliations

1. Faculty of Chemical, Petroleum and Gas Engineering, Semnan University, Semnan, 35196-45399, Iran
2. Department of Drug and Food Control, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Source: Chemical Papers Published:2021

Abstract

The objective of this work is to enhance the dissolution rate of a poorly water-soluble drug, aspirin, by production of micronized aspirin and aspirin/polyethylene glycol 4000 (aspirin/PEG4000) composite with pressure reduction of gas-expanded solution (PPRGEL) method. The obtained particles were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), differential scanning calorimetry (DSC) and Fourier-transform infrared spectroscopy (FTIR) analysis. Influence of different operating parameters (pressure, temperature, concentration) and solvent type on morphology and average size of products were investigated. It was found that the used technique decreases the mean size of the aspirin particles from 465 to 5.8 μm. The dissolution rate of the aspirin-PEG4000 composite was also studied. It was found that ~ 80% of aspirin in the composite was dissolved within the first 9.5 min of the dissolution process, while it was up to 60 min for the unprocessed aspirin. © 2020, Institute of Chemistry, Slovak Academy of Sciences.

2. Production of Ultrafine Clobetasol Propionate Via Rapid Expansion of Supercritical Solution (Ress): Full Factorial Approach, Journal of Supercritical Fluids (2015)

3. Production of Ibuprofen-Loaded Solid Lipid Nanoparticles Using Rapid Expansion of Supercritical Solution, Journal of Nano Research (2015)

4. Preparation and Characterization of Simvastatin Nanoparticles Using Rapid Expansion of Supercritical Solution (Ress) With Trifluoromethane, Journal of Supercritical Fluids (2016)

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Alireza Vatanara (2)

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Style	Citing Format
MLA	Rostamian H, Lotfollahi MN, Mohammadi A. "Micronization and Characterization of Ultrafine Pure and Composite Aspirin by Co2-Expanded Solution." Chemical Papers, vol. 75, no. 1, 2021, pp. 99-113.
APA	Rostamian H, Lotfollahi MN, Mohammadi A (2021). Micronization and Characterization of Ultrafine Pure and Composite Aspirin by Co2-Expanded Solution. Chemical Papers, 75(1), 99-113.
Chicago	Rostamian H, Lotfollahi MN, Mohammadi A. "Micronization and Characterization of Ultrafine Pure and Composite Aspirin by Co2-Expanded Solution." Chemical Papers 75, no. 1 (2021): 99-113.
Harvard	Rostamian H, Lotfollahi MN, Mohammadi A (2021) 'Micronization and Characterization of Ultrafine Pure and Composite Aspirin by Co2-Expanded Solution', Chemical Papers, 75(1), pp. 99-113.
Vancouver	Rostamian H, Lotfollahi MN, Mohammadi A. Micronization and Characterization of Ultrafine Pure and Composite Aspirin by Co2-Expanded Solution. Chemical Papers. 2021;75(1):99-113.
BibTex	@article{ author = {Rostamian H and Lotfollahi MN and Mohammadi A}, title = {Micronization and Characterization of Ultrafine Pure and Composite Aspirin by Co2-Expanded Solution}, journal = {Chemical Papers}, volume = {75}, number = {1}, pages = {99-113}, year = {2021} }
RIS	TY - JOUR AU - Rostamian H AU - Lotfollahi MN AU - Mohammadi A TI - Micronization and Characterization of Ultrafine Pure and Composite Aspirin by Co2-Expanded Solution JO - Chemical Papers VL - 75 IS - 1 SP - 99 EP - 113 PY - 2021 ER -

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