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Correlation Between the Clinical Disability and T1 Hypointense Lesions’ Volume in Cerebral Magnetic Resonance Imaging of Multiple Sclerosis Patients: A Systematic Review and Meta-Analysis Publisher Pubmed



Valizadeh A1 ; Moassefi M1 ; Barati E1 ; Ali Sahraian M1 ; Aghajani F1 ; Fattahi MR1
Authors
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Authors Affiliations
  1. 1. Tehran University of Medical Sciences, Tehran, Iran

Source: CNS Neuroscience and Therapeutics Published:2021


Abstract

Background: To evaluate the correlation between T1 hypointense lesions’ mean volume on cerebral MRI with disability level of patients with multiple sclerosis. Methods: We included studies testing the desired outcome in adult patients diagnosed with RRMS or SPMS. In Feb 2021, we searched PubMed, Embase, CENTRAL, and Web of Science to find relevant studies. All included studies were assessed for the risk of bias using a tailored version of the Quality in Prognosis Studies (QUIPS) tool. Extracted correlation coefficients were converted to the Fisher's z scale, and a meta-analysis using a random-effects model was performed on the results. Results: We included 27 studies (1919 participants). Meta-analysis revealed a correlation coefficient of 0.32 (95% CI 0.26–0.37) between T1 hypointense lesions’ mean volume and EDSS score. Discussion: The correlation between T1 hypointense lesions’ mean volume and EDSS was interpreted as low to slightly moderate. The certainty of the evidence was judged to be high. © 2021 The Authors. CNS Neuroscience & Therapeutics Published by John Wiley & Sons Ltd.
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