Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Radiation-Induced Heart Diseases: Protective Effects of Natural Products Publisher Pubmed



Musa AE1, 2 ; Shabeeb D3
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Medical Physics, Tehran University of Medical Sciences (TUMS), International Campus, Tehran, 1416753955, Iran
  2. 2. Research Center for Molecular and Cellular Imaging, TUMS, Tehran, 1416753955, Iran
  3. 3. Department of Physiology, College of Medicine, University of Misan, Misan, 62010, Iraq

Source: Medicina (Lithuania) Published:2019


Abstract

Cardiovascular diseases (CVDs) account for the majority of deaths worldwide. Radiation-induced heart diseases (RIHD) is one of the side effects following exposure to ionizing radiation (IR). Exposure could be from various forms such as diagnostic imaging, radiotherapy for cancer treatment, as well as nuclear disasters and nuclear accidents. RIHD is mostly observed after radiotherapy for thoracic malignancies, especially left breast cancer. RIHD may affect the supply of blood to heart muscles, leading to an increase in the risk of heart attacks to irradiated persons. Due to its dose-limiting consequence, RIHD has a negative effect on the therapeutic efficacy of radiotherapy. Several methods have been proposed for protection against RIHD. In this paper, we review the use of natural products, which have shown promising results for protection against RIHD. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.
Related Docs
View other Related Docs
1. Radioprotective Effect of Hesperidin: A Systematic Review, Medicina (Lithuania) (2019)
2. Radiation Protection and Mitigation by Natural Antioxidants and Flavonoids: Implications to Radiotherapy and Radiation Disasters, Current Molecular Pharmacology (2018)
3. Protective Effect of Melatonin Against Radiotherapy-Induced Small Intestinal Oxidative Stress: Biochemical Evaluation, Medicina (Lithuania) (2019)
4. Investigating Radioprotective Effect of Hesperidin/Diosmin Compound Against 99Mtc-Mibi-Induced Cardiotoxicity: Animal Study, Cardiovascular Toxicology (2022)
5. Melatonin As an Adjuvant in Radiotherapy for Radioprotection and Radiosensitization, Clinical and Translational Oncology (2019)
6. Metformin Protects Against Radiation-Induced Heart Injury and Attenuates the Upregulation of Dual Oxidase Genes Following Rat's Chest Irradiation, International Journal of Molecular and Cellular Medicine (2018)
7. Evaluating the Radioprotective Effect of Curcumin on Rat’S Heart Tissues, Current Radiopharmaceuticals (2019)
8. Melatonin a Promising Candidate for Dna Double-Stranded Breaks Reduction in Patients Undergoing Abdomen-Pelvis Computed Tomography Examinations, Anti-Cancer Agents in Medicinal Chemistry (2020)
Experts (# of related papers)
View all Related Experts
Elahe Motevaseli (17)
Hana Saffar (7)
Other Related Docs
9. Radioprotective Effects of Hesperidin on Oxidative Damages and Histopathological Changes Induced by X-Irradiation in Rats Heart Tissue, Journal of Medical Physics (2016)
10. Mechanisms for Radioprotection by Melatonin; Can It Be Used As a Radiation Countermeasure?, Current Molecular Pharmacology (2019)
11. Curcumin Protects Against Radiotherapy-Induced Oxidative Injury to the Skin, Drug Design# Development and Therapy (2020)
12. Radiation Protection by Ex-Rad: A Systematic Review, Environmental Science and Pollution Research (2020)
13. The Melatonin Immunomodulatory Actions in Radiotherapy, Biophysical Reviews (2017)
14. Evaluating the Protective Effect of a Combination of Curcumin and Selenium-L-Methionine on Radiation Induced Dual Oxidase Upregulation, Pharmaceutical Sciences (2018)
15. Biochemical and Histopathological Evaluation of the Radioprotective Effects of Melatonin Against Gamma Ray-Induced Skin Damage, Current Radiopharmaceuticals (2019)
16. Mechanisms of Inflammatory Responses to Radiation and Normal Tissues Toxicity: Clinical Implications, International Journal of Radiation Biology (2018)
17. Modulation of the Immune System by Melatonin; Implications for Cancer Therapy, International Immunopharmacology (2022)
18. Protection Against Ionizing Radiation-Induced Normal Tissue Damage by Resveratrol: A Systematic Review, Eurasian Journal of Medicine (2020)
19. Radiation-Induced Dual Oxidase Upregulation in Rat Heart Tissues: Protective Effect of Melatonin, Medicina (Lithuania) (2019)
20. Metformin Protects Against Radiation-Induced Pneumonitis and Fibrosis and Attenuates Upregulation of Dual Oxidase Genes Expression, Advanced Pharmaceutical Bulletin (2018)
21. Hesperidin As Radioprotector Against Radiation-Induced Lung Damage in Rat: A Histopathological Study, Journal of Medical Physics (2017)
22. Metformin As a Radiation Modifier; Implications to Normal Tissue Protection and Tumor Sensitization, Current Clinical Pharmacology (2019)
23. Protection Against Radiation-Induced Duox1 and Duox2 Upregulation in Rat's Lung Tissues by a Combination of Curcumin and L-Selenomethionine, Jundishapur Journal of Natural Pharmaceutical Products (2021)
24. Nadph Oxidase As a Target for Modulation of Radiation Response; Implications to Carcinogenesis and Radiotherapy, Current Molecular Pharmacology (2019)
25. Radioprotective Effects of Combined Melatonin and Famotidine Treatment on Radiation Induced Apoptosis in Peripheral Blood Leukocytes of Breast Cancer Patients and Normal Individuals, Cell Journal (2021)
26. Modulation of Apoptosis by Melatonin for Improving Cancer Treatment Efficiency: An Updated Review, Life Sciences (2019)
27. Ferulago Angulata As a Good Radioprotector Against Genotoxicity, Current Radiopharmaceuticals (2022)
28. Targets for Protection and Mitigation of Radiation Injury, Cellular and Molecular Life Sciences (2020)
29. Radiation-Induced Inflammation and Autoimmune Diseases, Military Medical Research (2018)
30. Metformin Protects the Rat Small Intestine Against Radiation Enteritis, Jundishapur Journal of Natural Pharmaceutical Products (2019)
31. Nf-Κb Targeting for Overcoming Tumor Resistance and Normal Tissues Toxicity, Journal of Cellular Physiology (2019)
32. Protective Effect of Selenium-L-Methionine on Radiation-Induced Acute Pneumonitis and Lung Fibrosis in Rat, Current Clinical Pharmacology (2019)
33. Melatonin Ameliorates Radiation-Induced Sciatic Nerve Injury, Letters in Drug Design and Discovery (2020)
34. Radiation-Induced Non-Targeted Effect and Carcinogenesis; Implications in Clinical Radiotherapy, Journal of Biomedical Physics and Engineering (2018)
35. Evidence for the Benefits of Melatonin in Cardiovascular Disease, Frontiers in Cardiovascular Medicine (2022)
36. Programmed Cell Death and Melatonin: A Comprehensive Review, Functional and Integrative Genomics (2024)
37. Antioxidant and Anti-Apoptotic Effects of Selenium Nanoparticles and Lactobacillus Casei on Mice Testis After X-Ray, Andrologia (2022)
38. Curcumin As an Anti-Inflammatory Agent: Implications to Radiotherapy and Chemotherapy, Journal of Cellular Physiology (2019)
39. Melatonin Attenuates Upregulation of Duox1 and Duox2 and Protects Against Lung Injury Following Chest Irradiation in Rats, Cell Journal (2019)
40. Melatonin As an Angiogenesis Inhibitor to Combat Cancer: Mechanistic Evidence, Toxicology and Applied Pharmacology (2017)
41. Oxidative Stress and Cancer; the Role of Hesperidin, a Citrus Natural Bioflavonoid, As a Cancer Chemoprotective Agent, Nutrition and Cancer (2016)
42. Investigating the Attenuating Effect of Telmisartan Against Radiation-Induced Intestinal Injury Using 18F-Fdg Micro-Pet Imaging, International Journal of Radiation Biology (2023)
43. Melatonin: A Smart Molecule in the Dna Repair System, Cell Biochemistry and Function (2022)
44. Curcumin Can Be Acts As Effective Agent for Prevent or Treatment of Alcohol-Induced Toxicity in Hepatocytes: An Illustrated Mechanistic Review, Iranian Journal of Pharmaceutical Research (2021)
45. Melatonin and 5-Fluorouracil Combination Chemotherapy: Opportunities and Efficacy in Cancer Therapy, Cell Communication and Signaling (2023)
46. Micronuclei Assessment of the Radioprotective Effects of Melatonin and Vitamin C in Human Lymphocytes, Cell Journal (2016)
47. Evaluating the Mitigation Effect of Spirulina Against Radiation-Induced Heart Injury, Current Radiopharmaceuticals (2023)
48. Intercellular Communications-Redox Interactions in Radiation Toxicity; Potential Targets for Radiation Mitigation, Journal of Cell Communication and Signaling (2019)
49. Comparison of Organs at Risk Doses Between Deep Inspiration Breath-Hold and Free-Breathing Techniques During Radiotherapy of Left-Sided Breast Cancer: A Meta-Analysis, Polish Journal of Medical Physics and Engineering (2022)
50. Application of Nano-Radiosensitizers in Combination Cancer Therapy, Bioengineering and Translational Medicine (2023)