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Radioprotective Effects of Hesperidin on Oxidative Damages and Histopathological Changes Induced by X-Irradiation in Rats Heart Tissue Publisher



Rezaeyan A1 ; Haddadi GH2 ; Hosseinzadeh M3 ; Moradi M4 ; Najafi M5
Authors
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Authors Affiliations
  1. 1. Department of Medical Physics, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran
  2. 2. Department of Radiology, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
  3. 3. Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
  4. 4. Food and Drug Organization, Fasa University of Medical Sciences, Fasa, Iran
  5. 5. Department of Medical Physics and Biomedical Engineering, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Medical Physics Published:2016


Abstract

This study was carried out to evaluate radioprotective effects of hesperidin (HES) administration before the irradiation on the cardiac oxidative stress and histopathological changes in an experimental rat model. The cardiovascular complications of radiation exposure cause morbidity and mortality in patients who received radiotherapy. HES, an antioxidant flavonoid found in citrus fruits, suggests the protection against the tissue damage. Fifty-eight rats were divided into four groups: Group 1 received phosphate buffered saline (PBS) and sham radiation; Group 2, HES and sham radiation; Group 3, PBS and radiation; and Group 4, HES and radiation. The rats were exposed to single dose of 18 Gy of 6 MV X-ray. One hundred milligrams per kilogram doses of HES was administered for 7 days before irradiation. The estimation of superoxide dismutase (SOD), malondialdehyde (MDA), and histopathological analyses was performed at 24 h and 8 weeks after radiation exposure. The irradiation of chest area resulted in an elevated MDA level and decreased SOD activity. Moreover, long-term pathological lesions of radiation were inflammation, fibrosis, the increased number of mast cells and macrophages, and development of plaque, vascular leakage, myocardial degeneration, and myocyte necrosis. Although the administration of HES decreases inflammation, fibrosis, mast cell and macrophage numbers, and myocyte necrosis, it did not result in reduced thrombus, myocardium degeneration, and vascular leakage. In conclusion, these results suggest that HES can perform a radioprotection action. The protective effect of HES may be attributable to its immunomodulatory effects and free radical-scavenging properties. © 2016 Journal of Medical Physics | Published by Wolters Kluwer - Medknow.
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