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Association of Interleukin 2, Interleukin 12, and Interferon-Γwith Intervertebral Disc Degeneration in Iranian Population Publisher Pubmed



Hanaei S1, 2, 3 ; Abdollahzade S4 ; Sadr M1 ; Mirbolouk MH5 ; Fattahi E5 ; Khoshnevisan A5 ; Rezaei N2, 3, 6
Authors
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Authors Affiliations
  1. 1. Molecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Dr Qarib St, Keshavarz Blvd, Tehran, 14194, Iran
  3. 3. Network of Immunity in Infection Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  4. 4. Division of Neurosurgery, Department of Surgery, Rajayi Hospital, Qazvin University of Medical Sciences, Qazvin, Iran
  5. 5. Department of Neurosurgery, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: BMC Medical Genetics Published:2020


Abstract

Background: Intervertebral disc degeneration (IVDD) is an age-related degenerative disease, presenting with low back pain or radicular pain. The inflammatory changes would occur in discs in the process of IVDD. Therefore, the inflammatory and anti-inflammatory cytokines, as well as their respective genes, have been proposed to play roles in pathophysiology of disease. This study has been conducted to elucidate the role of IL-2, IL-12, and IFN-γsingle nucleotide polymorphisms (SNP) in this disease. Method: Seventy-six patients who were diagnosed with IVDD and 140 healthy controls who complied with eligibility criteria were included. A total volume of 5 cc peripheral blood was obtained from each participant to investigate the IL-2 + 166G/T, IL-2-330G/T, IL-12-1188A/C, and IFN-γ+847A/T SNPs through PCR-SSP method. Results: The 'TG' and 'TT' genotypes of IL-2-330G/T polymorphism were significantly more common among patients and healthy controls respectively. The 'GT' and 'TT' haplotypes of IL-2 (comprised of-330G/T, and + 166G/T SNPs) were also more common among patients and controls respectively. Conclusion: This study indicated the significant role of IL-2 genotypes and haplotypes in IVDD. These SNPs were differently distributed in patients and controls. Therefore, alteration in the structure of IL-2 gene could play an important role in pathophysiology of IVDD. © 2020 The Author(s).
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Alireza Khoshnevisan (4)
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