Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Simple and Efficient Syntheses of Novel Benzo[4,5]Imidazo[1,2-A]Pyridine Derivatives Publisher



Goligarmroodi F1 ; Omidi M2 ; Saeedi M3 ; Sarrafzadeh F4 ; Rafinejad A3 ; Mahdavi M1 ; Bardajee GR2 ; Akbarzadeh T1, 3 ; Firoozpour L5 ; Shafiee A1 ; Foroumadi A1, 4
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Chemistry, Payame Noor University (PNU), PO BOX 19395-3697, Tehran, Iran
  3. 3. Persian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Neuroscience Research Center, Institute of Neuropharmacology and Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran
  5. 5. Drug Design and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Tetrahedron Letters Published:2015


Abstract

A novel series of benzo[4,5]imidazo[1,2-a]pyridine derivatives is synthesized through the reaction of 2-(1H-benzo[d]imidazol-2-yl)acetonitrile and different ethyl 2,4-dioxo-4-arylbutanoate derivatives in the presence of piperidine in refluxing EtOH. All the products are easily prepared within 25-45 min in good to excellent yields. © 2014 Elsevier Ltd. All rights reserved.