Synthesis of Novel Pyrazino[2,1-A]Isoindolediones Via Intramolecular Hydroamination of 2,3-Dihydro-3-Oxo-2-(Prop-2-Yn-1-Yl)-1H-Isoindole-1-Carboxamides

Synthesis of Novel Pyrazino[2,1-A]Isoindolediones Via Intramolecular Hydroamination of 2,3-Dihydro-3-Oxo-2-(Prop-2-Yn-1-Yl)-1H-Isoindole-1-Carboxamides Publisher

Esmaeilimarandi F¹ ; Yavari I¹ ; Saeedi M^{2, 3} ; Mahdavi M⁴ ; Shafiee A⁴

Show Affiliations

1. Department of Chemistry, Tehran Science and Research Branch, Islamic Azad University, Hesarak, Tehran, Iran
2. Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, 14176, Iran
3. Persian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, 14176, Iran
4. Department of Medicinal Chemistry, Faculty of Pharmacy, Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, 14176, Iran

Source: Helvetica Chimica Acta Published:2016

Abstract

Novel derivatives of pyrazino[2,1-a]isoindolediones were synthesized through 6-exo-dig intramolecular hydroamination of 2,3-dihydro-3-oxo-2-(prop-2-yn-1-yl)-1H-isoindole-1-carboxamides followed by 1,3-H shift, in the presence of sodium hydride in DMF at 80°. All products were obtained in good yields (60 - 80%) within short reaction time (40 - 60 min). © 2016 Verlag Helvetica Chimica Acta AG, Zurich.

Style	Citing Format
MLA	Esmaeilimarandi F, et al.. "Synthesis of Novel Pyrazino[2,1-A]Isoindolediones Via Intramolecular Hydroamination of 2,3-Dihydro-3-Oxo-2-(Prop-2-Yn-1-Yl)-1H-Isoindole-1-Carboxamides." Helvetica Chimica Acta, vol. 99, no. 3, 2016, pp. 187-190.
APA	Esmaeilimarandi F, Yavari I, Saeedi M, Mahdavi M, Shafiee A (2016). Synthesis of Novel Pyrazino[2,1-A]Isoindolediones Via Intramolecular Hydroamination of 2,3-Dihydro-3-Oxo-2-(Prop-2-Yn-1-Yl)-1H-Isoindole-1-Carboxamides. Helvetica Chimica Acta, 99(3), 187-190.
Chicago	Esmaeilimarandi F, Yavari I, Saeedi M, Mahdavi M, Shafiee A. "Synthesis of Novel Pyrazino[2,1-A]Isoindolediones Via Intramolecular Hydroamination of 2,3-Dihydro-3-Oxo-2-(Prop-2-Yn-1-Yl)-1H-Isoindole-1-Carboxamides." Helvetica Chimica Acta 99, no. 3 (2016): 187-190.
Harvard	Esmaeilimarandi F et al. (2016) 'Synthesis of Novel Pyrazino[2,1-A]Isoindolediones Via Intramolecular Hydroamination of 2,3-Dihydro-3-Oxo-2-(Prop-2-Yn-1-Yl)-1H-Isoindole-1-Carboxamides', Helvetica Chimica Acta, 99(3), pp. 187-190.
Vancouver	Esmaeilimarandi F, Yavari I, Saeedi M, Mahdavi M, Shafiee A. Synthesis of Novel Pyrazino[2,1-A]Isoindolediones Via Intramolecular Hydroamination of 2,3-Dihydro-3-Oxo-2-(Prop-2-Yn-1-Yl)-1H-Isoindole-1-Carboxamides. Helvetica Chimica Acta. 2016;99(3):187-190.
BibTex	@article{ author = {Esmaeilimarandi F and Yavari I and Saeedi M and Mahdavi M and Shafiee A}, title = {Synthesis of Novel Pyrazino[2,1-A]Isoindolediones Via Intramolecular Hydroamination of 2,3-Dihydro-3-Oxo-2-(Prop-2-Yn-1-Yl)-1H-Isoindole-1-Carboxamides}, journal = {Helvetica Chimica Acta}, volume = {99}, number = {3}, pages = {187-190}, year = {2016} }
RIS	TY - JOUR AU - Esmaeilimarandi F AU - Yavari I AU - Saeedi M AU - Mahdavi M AU - Shafiee A TI - Synthesis of Novel Pyrazino[2,1-A]Isoindolediones Via Intramolecular Hydroamination of 2,3-Dihydro-3-Oxo-2-(Prop-2-Yn-1-Yl)-1H-Isoindole-1-Carboxamides JO - Helvetica Chimica Acta VL - 99 IS - 3 SP - 187 EP - 190 PY - 2016 ER -

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