Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Dietary Total Antioxidant Capacity and Colorectal Cancer and Colorectal Adenomatous Polyps: A Case-Control Study Publisher Pubmed



Rafiee P1, 2 ; Jafari Nasab S2 ; Bahrami A2 ; Rezaeimanesh N3 ; Jalali S4 ; Hekmatdoost A2 ; Sadeghi A5 ; Naja F6 ; Houshyari M7 ; Hejazi E2
Authors

Source: European Journal of Cancer Prevention Published:2021


Abstract

Colorectal cancer (CRC) is the third most common and the third most deadly cancer worldwide. In Iran, CRC is the third and fifth most common cancer in females and males, respectively. Chronic oxidative stress has been implicated in the development of CRC and its precursor, colorectal adenomatous polyps (CAP). While there were a few studies that suggested a favorable role of individuals antioxidants on the CRC risk, the total antioxidant capacity (TAC) of diet has been less investigated. Consequently, the aim of this study is to investigate the association of TAC with the odds of CRC and CAP. This is a case-control study. The participants were 130 cases with incident, histologically confirmed CRC, 134 cases with incident of CAP and 243 hospital-based controls. TAC has been assessed with dietary ferric-reducing antioxidant potential and oxygen radical absorbance capacity method based on collected dietary intake data through a reproducible and valid food frequency questionnaire. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for the association between the TAC and CRC and CAP odds were estimated by multiple logistic regression. After controlling for potential confounders, TAC was significantly associated with CRC and CAP odds. (ORQ3-Q1for CRC = 0.25, 95% CI: 0.13-0.46, Ptrend = 0.001. ORQ3-Q1for CAP = 0.48, 95% CI: 0.27-0.85, Ptrend= 0.01). The findings of this study suggested an inverse association between TAC and CRC and CAP risk. © 2021 Lippincott Williams and Wilkins. All rights reserved.
Other Related Docs
10. Dietary and Biochemical Characteristics Associated With Normal-Weight Obesity, International Journal for Vitamin and Nutrition Research (2019)
17. Dietary Total Antioxidant Capacity and Gastric Cancer: A Case-Control Study, Journal of Nutrition and Food Security (2025)
19. Survival Rate of Colorectal Cancer in Iran: A Systematic Review and Meta-Analysis, Asian Pacific Journal of Cancer Prevention (2019)