Clinical Significance of Ndrg3 in Patients With Breast Cancer

Clinical Significance of Ndrg3 in Patients With Breast Cancer Publisher Pubmed

Estiar MA¹ ; Zare AA² ; Esmaeili R³ ; Farahmand L³ ; Fazilaty H⁴ ; Jafari D⁵ ; Samadi T³ ; Majidzadeha K³

Show Affiliations

1. Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
2. Recombinant Proteins Department, Breast Cancer Research Center, ACECR, Tehran, Iran
3. Cancer Genetics Department, Breast Cancer Research Center, ACECR, Tehran, Iran
4. Developmental Neurobiology, Instituto de Neurociencias UMH-SIC, Alicante, Spain
5. Department of Immunology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Future Oncology Published:2017

Abstract

Aim: The expression level of NDRG3 gene is investigated among breast cancer (BC) patients. Methods: Real-time quantitative PCR was performed. Results: NDRG3 was downregulated in BC patients particularly in advanced stage of the disease. HER2 status was significantly correlated with the expression of NDRG3. Also, triple-negative BC patients showed low levels of NDRG3 expression in comparison to other subtypes. Lastly, the expression of NDRG3 had significant impact on survival, with NDRG3 downregulated patients having the worst event-free survival rate among others. Conclusion: We have presented that NDRG3 might be a tumor suppressor candidate. NDRG3 downregulation might be involved in the tumorigenesis and development of invasive BC in an advanced phase of the disease. © 2017 Future Medicine Ltd.

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Style	Citing Format
MLA	Estiar MA, et al.. "Clinical Significance of Ndrg3 in Patients With Breast Cancer." Future Oncology, vol. 13, no. 11, 2017, pp. 961-969.
APA	Estiar MA, Zare AA, Esmaeili R, Farahmand L, Fazilaty H, Jafari D, Samadi T, Majidzadeha K (2017). Clinical Significance of Ndrg3 in Patients With Breast Cancer. Future Oncology, 13(11), 961-969.
Chicago	Estiar MA, Zare AA, Esmaeili R, Farahmand L, Fazilaty H, Jafari D, Samadi T, Majidzadeha K. "Clinical Significance of Ndrg3 in Patients With Breast Cancer." Future Oncology 13, no. 11 (2017): 961-969.
Harvard	Estiar MA et al. (2017) 'Clinical Significance of Ndrg3 in Patients With Breast Cancer', Future Oncology, 13(11), pp. 961-969.
Vancouver	Estiar MA, Zare AA, Esmaeili R, Farahmand L, Fazilaty H, Jafari D, et al.. Clinical Significance of Ndrg3 in Patients With Breast Cancer. Future Oncology. 2017;13(11):961-969.
BibTex	@article{ author = {Estiar MA and Zare AA and Esmaeili R and Farahmand L and Fazilaty H and Jafari D and Samadi T and Majidzadeha K}, title = {Clinical Significance of Ndrg3 in Patients With Breast Cancer}, journal = {Future Oncology}, volume = {13}, number = {11}, pages = {961-969}, year = {2017} }
RIS	TY - JOUR AU - Estiar MA AU - Zare AA AU - Esmaeili R AU - Farahmand L AU - Fazilaty H AU - Jafari D AU - Samadi T AU - Majidzadeha K TI - Clinical Significance of Ndrg3 in Patients With Breast Cancer JO - Future Oncology VL - 13 IS - 11 SP - 961 EP - 969 PY - 2017 ER -

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