Synchronic Effect of Curcumin and Swimming Training on Depression Level in Morphine Dependent Male Mice



Elhampour L¹ ; Azarbayjani MA¹ ; Nasehi M² ; Piri M¹ ; Zarindast MR³ Show Affiliations
Source: Journal of Medicinal Plants Published:2017

Abstract

Background: There is need to more research because of extent drug trade in country and diversity of proposal cures such as non pharmacological ways including exercise and herbal supplements medicine. Objective: The aim of this study was investigation of synchronic effect of Curcumin and swim training on depression in morphine dependent male mice. Methods: In an experimental research, 40 Albino NMRI male mice with 19-21 gr were selected as subjects and they were divide randomly to care groups of control, morphine, swim training, Curcumin, Swim training+ Curcumin. Subjects swam 60 min/day, 5 days/week for 1 week with receiving Curcumin. Then, they were taken morphine (2.5 mg/ml/kg) for 5 days with swim training. Therefore FST was done and after 10 days this test was taken again. Results: Training increased swimming activity time, but it had no significant effect on immobility and climbing activities. At this period, Curcumin supplement caused increasing the time of climbing activities and no alteration in immobility and swimming times. Curcumin supplement with swim training caused increasing immobility time and decreasing swimming time, but it had no significant effect on climbing activities time. Conclusion: The results of this research showed that morphine consumption didn't cause depression. Also, combination of Curcumin supplement and swim training didn't cause depression decreasing in morphine consumption term.