Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Curcumin Confers Neuroprotection Against Alcohol-Induced Hippocampal Neurodegeneration Via Creb-Bdnf Pathway in Rats Publisher Pubmed



Motaghinejad M1 ; Motevalian M1 ; Fatima S2 ; Hashemi H1 ; Gholami M3
Authors
Show Affiliations
Authors Affiliations
  1. 1. Razi Drug Research Center & Department of Pharmacology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Physiology, Tehran University of Medical Sciences, International Campus, Tehran, Iran
  3. 3. Department of Medical Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Source: Biomedicine and Pharmacotherapy Published:2017


Abstract

Background Alcohol abuse causes severe damage to the brain neurons. Studies have reported the neuroprotective effects of curcumin against alcohol-induced neurodegeneration. However, the precise mechanism of action remains unclear. Methods Seventy rats were equally divided into 7 groups (10 rats per group). Group 1 received normal saline (0.7 ml/rat) and group 2 received alcohol (2 g/kg/day) for 21 days. Groups 3, 4, 5 and 6 concurrently received alcohol (2 g/kg/day) and curcumin (10, 20, 40 and 60 mg/kg, respectively) for 21 days. Animals in group 7 self- administered alcohol for 21 days. Group 8 treated with curcumin (60 mg/kg, i.p.) alone for 21 days. Open Field Test (OFT) was used to investigate motor activity in rats. Hippocampal oxidative, antioxidative and inflammatory factors were evaluated. Furthermore, brain cyclic adenosine monophosphate (cAMP) response element binding protein (CREB) and brain derived neurotrophic factor (BDNF) levels were studied at gene level by reverse transcriptase polymerase chain reaction (RT-PCR). In addition, protein expression for BDNF, CREB, phosphorylated CREB (CREB-P), Bax and Bcl-2 was determined by western blotting. Result Voluntary and involuntary administration of alcohol altered motor activity in OFT, and curcumin treatment inhibited this alcohol-induced motor disturbance. Also, alcohol administration augmented lipid peroxidation, mitochondrial oxidized glutathione (GSSG), interleukin-1 beta (IL-1β), tumor necrosis factor-alpha (TNF-α) and Bax levels in isolated hippocampal tissues. Furthermore, alcohol-induced significant reduction were observed in reduced form of glutathione (GSH), superoxide dismutase (SOD), glutathione peroxidase (GPx) and glutathione reductase (GR) activities and CREB, BDNF and Bcl-2 levels. Also curcumin alone did not change the behavior and biochemical and molecular parameters. Conclusion Curcumin can act as a neuroprotective agent against neurodegenerative effects of alcohol abuse, probably via activation of CREB-BDNF signaling pathway. © 2017 Elsevier Masson SAS
Related Docs
View other Related Docs
1. Novel Insight to Neuroprotective Potential of Curcumin: A Mechanistic Review of Possible Involvement of Mitochondrial Biogenesis and Pi3/Akt/ Gsk3 or Pi3/Akt/Creb/Bdnf Signaling Pathways, International Journal of Molecular and Cellular Medicine (2020)
2. Possible Involvement of Creb/Bdnf Signaling Pathway in Neuroprotective Effects of Topiramate Against Methylphenidate Induced Apoptosis, Oxidative Stress and Inflammation in Isolated Hippocampus of Rats: Molecular, Biochemical and Histological Evidences, Brain Research Bulletin (2017)
3. Topiramate Confers Neuroprotection Against Methylphenidate-Induced Neurodegeneration in Dentate Gyrus and Ca1 Regions of Hippocampus Via Creb/Bdnf Pathway in Rats, Neurotoxicity Research (2017)
4. Mediatory Role of Nmda, Ampa/Kainate, Gabaa and Alpha2 Receptors in Topiramate Neuroprotective Effects Against Methylphenidate Induced Neurotoxicity in Rat, Life Sciences (2017)
5. Neuroprotective Effects of Various Doses of Topiramate Against Methylphenidate-Induced Oxidative Stress and Inflammation in Isolated Rat Amygdala: The Possible Role of Creb/Bdnf Signaling Pathway, Journal of Neural Transmission (2016)
6. Effects of Acute Doses of Methylphenidate on Inflammation and Oxidative Stress in Isolated Hippocampus and Cerebral Cortex of Adult Rats, Journal of Neural Transmission (2017)
7. The Neuroprotective Effect of Lithium Against High Dose Methylphenidate: Possible Role of Bdnf, NeuroToxicology (2016)
8. The Combination of Swimming and Curcumin Consumption May Improve Spatial Memory Recovery After Binge Ethanol Drinking, Physiology and Behavior (2019)
Experts (# of related papers)
View all Related Experts
Mohammad Abdollahi (3)
Mohammad Hassan Javanbakht (2)
Other Related Docs
9. Crocin May Be Useful to Prevent or Treatment of Alcohol Induced Neurodegeneration and Neurobehavioral Sequels Via Modulation of Creb/Bdnf and Akt/Gsk Signaling Pathway, Medical Hypotheses (2019)
10. Curcumin Can Be Acts As Effective Agent for Prevent or Treatment of Alcohol-Induced Toxicity in Hepatocytes: An Illustrated Mechanistic Review, Iranian Journal of Pharmaceutical Research (2021)
11. The Effect of Maternal Forced Exercise on Offspring Pain Perception, Motor Activity and Anxiety Disorder: The Role of 5-Ht2 and D2 Receptors and Creb Gene Expression, Journal of Exercise Rehabilitation (2017)
12. Pharmacological Evidence for Lithium-Induced Neuroprotection Against Methamphetamine-Induced Neurodegeneration Via Akt- 1/Gsk3 and Creb-Bdnf Signaling Pathways, Iranian Journal of Basic Medical Sciences (2019)
13. Protective Effects of Various Dosage of Curcumin Against Morphine Induced Apoptosis and Oxidative Stress in Rat Isolated Hippocampus, Pharmacological Reports (2015)
14. Preventive Effects of Topiramate on Methylphenidate Induced Behavioral Disorders; [Efectos Preventivos De Topiramato En Los Trastornos Del Comportamiento Inducidos Por Metilfenidato], Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas (2019)
15. Synchronic Effect of Curcumin and Swimming Training on Depression Level in Morphine Dependent Male Mice, Journal of Medicinal Plants (2017)
16. Neuroprotective Properties of Minocycline Against Methylphenidate-Induced Neurodegeneration: Possible Role of Creb/Bdnf and Akt/Gsk3 Signaling Pathways in Rat Hippocampus, Neurotoxicity Research (2022)
17. Neuroinflammation As a Potential Therapeutic Target in Neuroimmunological Diseases, Translational Neuroimmunology: Neuroinflammation: Volume 7 (2023)
18. Short-Term Curcumin Supplementation Enhances Serum Brain-Derived Neurotrophic Factor in Adult Men and Women: A Systematic Review and Dose–Response Meta-Analysis of Randomized Controlled Trials, Nutrition Research (2019)
19. Pharmacological and Molecular Evidence of Neuroprotective Curcumin Effects Against Biochemical and Behavioral Sequels Caused by Methamphetamine: Possible Function of Creb-Bdnf Signaling Pathway, Basic and Clinical Neuroscience (2021)
20. Combination of Curcumin With Autologous Transplantation of Adult Neural Stem/Progenitor Cells Leads to More Efficient Repair of Damaged Cerebral Tissue of Rat, Experimental Physiology (2020)
21. Impact of Curcumin on P38 Mapk: Therapeutic Implications, Inflammopharmacology (2023)
22. Effect of Vitamin D Supplementation on Inflammatory Biomarkers in School-Aged Children With Attention Deficit Hyperactivity Disorder, International Journal of Clinical Practice (2022)
23. Beneficial Effects of Nano-Curcumin Supplement on Depression and Anxiety in Diabetic Patients With Peripheral Neuropathy: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial, Phytotherapy Research (2020)
24. Selegiline Acts As Neuroprotective Agent Against Methamphetamine-Prompted Mood and Cognitive Related Behavior and Neurotoxicity in Rats: Involvement of Creb/Bdnf and Akt/Gsk3 Signal Pathways, Iranian Journal of Basic Medical Sciences (2020)
25. Crocin Acting As a Neuroprotective Agent Against Methamphetamine-Induced Neurodegeneration Via Creb-Bdnf Signaling Pathway, Iranian Journal of Pharmaceutical Research (2019)
26. Preventive Effects of Duloxetine Against Methamphetamine Induced Neurodegeneration and Motor Activity Disorder in Rat: Possible Role of Creb/Bdnf Signaling Pathway, International Journal of Preventive Medicine (2019)
27. Therapeutic Potentials of Curcumin in the Treatment of Non-Small-Cell Lung Carcinoma, Phytotherapy Research (2020)
28. Curcumin As a Double-Edged Sword for Stem Cells: Dose, Time and Cell Type-Specific Responses to Curcumin, DARU# Journal of Pharmaceutical Sciences (2015)
29. Long-Term Administration of High-Dose Methylphenidate-Induced Cerebellar Morphology and Function Damage in Adult Rats, Journal of Chemical Neuroanatomy (2020)
30. Curcumin in Liver Diseases: A Systematic Review of the Cellular Mechanisms of Oxidative Stress and Clinical Perspective, Nutrients (2018)
31. Effect of Vitamin D Supplementation on Creb-Trkb-Bdnf Pathway in the Hippocampus of Diabetic Rats, Iranian Journal of Basic Medical Sciences (2020)
32. Curcumin Attenuates Severity of Premenstrual Syndrome Symptoms: A Randomized, Double-Blind, Placebo-Controlled Trial, Complementary Therapies in Medicine (2015)
33. Nepeta Menthoides Boiss. & Buhse Freeze-Dried Aqueous Extract Versus Sertraline in the Treatment of Major Depression: A Double Blind Randomized Controlled Trial, Complementary Therapies in Medicine (2016)
34. Pharmacological Effects and Therapeutic Potential of Natural Compounds in Neuropsychiatric Disorders: An Update, Frontiers in Pharmacology (2022)
35. Duloxetine by Modulating the Akt/Gsk3 Signaling Pathways Has Neuroprotective Effects Against Methamphetamine-Induced Neurodegeneration and Cognition Impairment in Rats, Iranian Journal of Medical Sciences (2019)
36. Repeated Pre-Exposure to Morphine Inhibited the Amnesic Effect of Ethanol on Spatial Memory: Involvement of Camkii and Bdnf, Alcohol (2024)
37. Effect of Curcumin on Serum Brain-Derived Neurotrophic Factor Levels in Women With Premenstrual Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial, Neuropeptides (2016)
38. Nrf2 Regulation by Curcumin: Molecular Aspects for Therapeutic Prospects, Molecules (2022)
39. Exploring Acupuncture As a Therapeutic Approach for Tic Disorders: A Review of Current Understanding and Potential Benefits, Frontiers in Neurology (2025)
40. Crocin Has a Greater Therapeutic Role in the Restoration of Behavioral Impairments Caused by Maternal Social Isolation in Adolescent Than in Adult Offspring Probably Through Gsk-3Beta Downregulation, Learning and Motivation (2024)
41. Curcumin Prevents Cognitive Deficits in the Bile Duct Ligated Rats, Psychopharmacology (2020)