Vitamin D Suppresses Proangiogenic Factors in Patients With Ulcerative Colitis: A Randomized Double Blind Placebo Controlled Clinical Trial Publisher Pubmed



Emami MR¹ ; Sharifi A² ; Yaseri M³ ; Derakhshanian H^{4, 5} ; Hosseinzadehattar MJ^{1, 6} Show Affiliations
Source: Complementary Therapies in Clinical Practice Published:2020

Abstract

Background: Angiogenesis and inflammation are involved in the pathogenesis of ulcerative colitis (UC). This study aimed to assess the effect of vitamin D on serum levels of proangiogenic factors, visfatin and vascular endothelial growth factor (VEGF), in patients with UC. Materials and methods: Ninety patients were randomized to receive either a single intramuscular injection of 300,000 IU vitamin D or normal saline. Visfatin, VEGF, and 25-hydroxyvitamin D [25(OH)D] concentrations were assessed before and 90 days after the intervention. Results: There were no significant differences in visfatin and VEGF levels between the two groups following supplementation. In patients with vitamin D insufficiency, visfatin increase was significantly lower in the intervention versus placebo group. There was an inverse correlation between serum 25(OH)D and visfatin in the subgroup with vitamin D insufficiency. Conclusion: Vitamin D might be beneficial in decreasing proangiogenic factors such as visfatin in UC patients with low 25(OH)D levels. © 2020 Elsevier Ltd