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Vitamin D Increases Ctla-4 Gene Expression in Patients With Mild to Moderate Ulcerative Colitis Publisher



Sharifi A1 ; Vahedi H2 ; Honarvar MR3 ; Alipoor B4 ; Nikniaz Z5 ; Rafiei H6 ; Hosseinzadehattar MJ7
Authors
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Authors Affiliations
  1. 1. Golestan Research Center of Gastroenterology and Hepatology (GRCGH), Faculty of health, Golestan University of Medical Sciences (GOUMS), Gorgan, Iran
  2. 2. Digestive Disease Research Center, Digestive Research Institute, Shariati ‎Hospital, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Health Management and Social Development Research Center, Faculty of Health, Golestan University of Medical Sciences, Gorgan, Iran
  4. 4. Department of Laboratory Sciences, Faculty of Paramedicine, Yasuj University of Medical Sciences, Yasuj, Iran
  5. 5. Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  6. 6. Faculty of Health and Social Development, College of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, BC, Canada
  7. 7. Department of Clinical Nutrition, School of Nutritional Sciences and ‎Dietetics, Tehran University of Medical Sciences, Tehran, Iran

Source: Middle East Journal of Digestive Diseases Published:2019


Abstract

BACKGROUND Ulcerative colitis (UC) is a chronic inflammatory disorder of the large intestine. Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) is a member of the immunoglobulin superfamily, which binds B7-1 and B7-2 on APCs (antigen-presenting cells), and induces APCs to produce an inhibitory signal to T cells. The aim of this study was to investigate the effect of vitamin D on CTLA-4 gene expression in whole blood samples of patients with UC. METHODS 90 patients with mild to moderate UC were randomized to receive either a single injection of 7.5 mg vitamin D3 or 1 mL normal saline. 90 days following the intervention fold changes in CTLA-4 mRNA expression were determined and statistical comparisons between the two groups were performed. RESULTS Serum vitamin D increased significantly only in the vitamin D group. CTLA-4 fold changes were significantly higher in the vitamin D group compared with the placebo group (median ± IQR: 1.21 ± 2.3 vs. 1.00 ± 1.5, respectively; p = 0.007). CONCLUSION The results of this study revealed that vitamin D administration in patients with UC enhances the CTLA-4 gene expression. © 2019 The Author(s).
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