Effects of Repeated Intra-Silicone Oil Injections of Methotrexate on Proliferative Vitreoretinopathy Grade C: A Multicenter Randomized Controlled Trial

Effects of Repeated Intra-Silicone Oil Injections of Methotrexate on Proliferative Vitreoretinopathy Grade C: A Multicenter Randomized Controlled Trial Publisher Pubmed

Nourinia R¹ ; Safi S² ; Mohammadpour M¹ ; Riaziesfahani H³ ; Ansari Astaneh MR⁴ ; Falavarjani KG⁵ ; Ramezani A^{2, 6, 7} ; Karimi S^{1, 6, 7, 8} ; Fekri S^{1, 8} ; Ebrahimiadib N³ ; Khalili Pour E³ ; Nikkhah H^{1, 6, 7} ; Shoeibi N⁴ ; Hassanpoor N⁹ Show All Authors

Nourinia R¹
Safi S²
Mohammadpour M¹
Riaziesfahani H³
Ansari Astaneh MR⁴
Falavarjani KG⁵
Ramezani A^{2, 6, 7}
Karimi S^{1, 6, 7, 8}
Fekri S^{1, 8}
Ebrahimiadib N³
Khalili Pour E³
Nikkhah H^{1, 6, 7}
Shoeibi N⁴
Hassanpoor N⁹
Hosseini M⁴
Abrishami M⁴
Abdi F⁵
Rahimi A¹¹
Jabbarpoor Bonyadi MH¹²
Moradian S^{2, 8}
Khosravi Mirzaei S^{1, 13}
Safi H^{1, 6}
Anvari P⁵
Fadakar K³
Mirghorbani M³
Mohammadbagheri N¹
Hatami F^{1, 13}
Kheiri B^{1, 2}
Yaseri M¹⁴
Khorrami Z²
Ahmadieh H¹

Show Affiliations

1. Ophthalmic Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, No. 23, Paidarfard St., Pasdaran Ave., Tehran, 16666, Iran
2. Ophthalmic Epidemiology Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3. Translational Ophthalmology Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran
4. Eye Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
5. Eye Research Center, The five Senses Health Institute, Moheb Kowsar Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
6. Department of Ophthalmology, Imam Hossein Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
7. Department of Ophthalmology, Torfeh Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
8. Labbafinejad Medical Center, Department of Ophthalmology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
9. Retina & amp
10. Vitreous Service, Nikookari Eye Hospital, Tabriz University of Medical Sciences, Tabriz, Iran
11. Negah Aref Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
12. Hakiman-e Noor Eye Hospital, Tabriz, Iran
13. Ocular Tissue Engineering Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran
14. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

Source: Scientific Reports Published:2024

Abstract

In this randomized controlled trial, we assessed the effects of three consecutive intra-silicone oil (SO) injections of methotrexate (MTX) on the outcomes of surgery for proliferative vitreoretinopathy grade C (PVR-C). Seventy-four eyes of 74 patients with PVR-C were included. Of these, 37 eyes were assigned to the MTX group and 37 eyes to the control group. Fourteen patients failed to comply with the 6-month follow-up period. All eyes underwent vitrectomy and SO injection. In the MTX group, 250 µg MTX was injected into the SO after surgery and at weeks 3 and 6 postoperatively. The primary outcome was the retinal reattachment rate at 6 months. The secondary outcomes included limited PVR recurrence and adverse events. Retinal reattachment was achieved in 22 eyes (73.3%) in the MTX group and 23 eyes (76.7%) in the control group (difference: -3.4%, 95% CI: -25.2–18.5%). Limited PVR recurrence was observed in one eye (4.5%) in the MTX group versus nine eyes (39.1%) in the control group at 6 months (P = 0.01). No adverse effects were observed. Adjunctive treatment with three consecutive applications of intra-SO MTX did not reveal a significant effect on the retinal re-detachment rate but could statistically significantly reduce limited PVR recurrence. Trial registration: http//ClinicalTrials.gov NCT04482543, 22/07/2020. © The Author(s) 2024.

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Style	Citing Format
MLA	Nourinia R, et al.. "Effects of Repeated Intra-Silicone Oil Injections of Methotrexate on Proliferative Vitreoretinopathy Grade C: A Multicenter Randomized Controlled Trial." Scientific Reports, vol. 14, no. 1, 2024, pp. -.
APA	Nourinia R, Safi S, Mohammadpour M, Riaziesfahani H, Ansari Astaneh MR, Falavarjani KG, Ramezani A, Karimi S, Fekri S, Ebrahimiadib N, Khalili Pour E, Nikkhah H, Shoeibi N, Hassanpoor N, Hosseini M, Abrishami M, Abdi F, Rahimi A, Jabbarpoor Bonyadi MH, ... Ahmadieh H (2024). Effects of Repeated Intra-Silicone Oil Injections of Methotrexate on Proliferative Vitreoretinopathy Grade C: A Multicenter Randomized Controlled Trial. Scientific Reports, 14(1), -.
Chicago	Nourinia R, Safi S, Mohammadpour M, Riaziesfahani H, Ansari Astaneh MR, Falavarjani KG, Ramezani A, et al.. "Effects of Repeated Intra-Silicone Oil Injections of Methotrexate on Proliferative Vitreoretinopathy Grade C: A Multicenter Randomized Controlled Trial." Scientific Reports 14, no. 1 (2024): -.
Harvard	Nourinia R et al. (2024) 'Effects of Repeated Intra-Silicone Oil Injections of Methotrexate on Proliferative Vitreoretinopathy Grade C: A Multicenter Randomized Controlled Trial', Scientific Reports, 14(1), pp. -.
Vancouver	Nourinia R, Safi S, Mohammadpour M, Riaziesfahani H, Ansari Astaneh MR, Falavarjani KG, et al.. Effects of Repeated Intra-Silicone Oil Injections of Methotrexate on Proliferative Vitreoretinopathy Grade C: A Multicenter Randomized Controlled Trial. Scientific Reports. 2024;14(1):-.
BibTex	@article{ author = {Nourinia R and Safi S and Mohammadpour M and Riaziesfahani H and Ansari Astaneh MR and Falavarjani KG and Ramezani A and Karimi S and Fekri S and Ebrahimiadib N and Khalili Pour E and Nikkhah H and Shoeibi N and Hassanpoor N and Hosseini M and Abrishami M and Abdi F and Rahimi A and Jabbarpoor Bonyadi MH and Moradian S and Khosravi Mirzaei S and Safi H and Anvari P and Fadakar K and Mirghorbani M and Mohammadbagheri N and Hatami F and Kheiri B and Yaseri M and Khorrami Z and Ahmadieh H}, title = {Effects of Repeated Intra-Silicone Oil Injections of Methotrexate on Proliferative Vitreoretinopathy Grade C: A Multicenter Randomized Controlled Trial}, journal = {Scientific Reports}, volume = {14}, number = {1}, pages = {-}, year = {2024} }
RIS	TY - JOUR AU - Nourinia R AU - Safi S AU - Mohammadpour M AU - Riaziesfahani H AU - Ansari Astaneh MR AU - Falavarjani KG AU - Ramezani A AU - Karimi S AU - Fekri S AU - Ebrahimiadib N AU - Khalili Pour E AU - Nikkhah H AU - Shoeibi N AU - Hassanpoor N AU - Hosseini M AU - Abrishami M AU - Abdi F AU - Rahimi A AU - Jabbarpoor Bonyadi MH AU - Moradian S AU - Khosravi Mirzaei S AU - Safi H AU - Anvari P AU - Fadakar K AU - Mirghorbani M AU - Mohammadbagheri N AU - Hatami F AU - Kheiri B AU - Yaseri M AU - Khorrami Z AU - Ahmadieh H TI - Effects of Repeated Intra-Silicone Oil Injections of Methotrexate on Proliferative Vitreoretinopathy Grade C: A Multicenter Randomized Controlled Trial JO - Scientific Reports VL - 14 IS - 1 SP - EP - PY - 2024 ER -

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