Cirbp Mrna Level in Breast Cancer Is Associated With Hif1α Gene Expression and Microvascular Density

Cirbp Mrna Level in Breast Cancer Is Associated With Hif1α Gene Expression and Microvascular Density Publisher Pubmed

Monjezi S^{1, 4} ; Soleimani V² ; Cheraghzadeh M¹ ; Ghanbari S³ ; Adelipour M^{1, 4}

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1. Department of Biochemistry, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
2. Department of Pathology, School of Medicine, Cancer Institute, Tehran University of Medical Science, Tehran, Iran
3. Department of Biostatistics and Epidemiology, School of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
4. Cellular and molecular research center, Medical Basic Science Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Source: BMC Research Notes Published:2025

Abstract

Objective: Based on the available evidence, the cold-inducible RNA-binding protein (CIRBP) appears to play a role in increasing the stability of hypoxia-inducible factor 1-alpha (HIF1α) mRNA. This research aimed to examine the levels of CIRBP and HIF1α mRNA within breast tumor tissues and explore the relationship between their gene expression and tumor Microvascular density (MVD). Results: The results revealed a significant upregulation of CIRBP (5.07-fold) and HIF1α (4.5-fold) gene expression in BC samples compared to the surrounding normal tissues (p < 0.001). This upregulation was also associated with various clinicopathologic features. Furthermore, there was a correlation between CIRBP mRNA expression, HIF1α mRNA expression, and MVD. Consequently, this study suggests that CIRBP may have a role in promoting angiogenesis in BC. © The Author(s) 2025.

Style	Citing Format
MLA	Monjezi S, et al.. "Cirbp Mrna Level in Breast Cancer Is Associated With Hif1α Gene Expression and Microvascular Density." BMC Research Notes, vol. 18, no. 1, 2025, pp. -.
APA	Monjezi S, Soleimani V, Cheraghzadeh M, Ghanbari S, Adelipour M (2025). Cirbp Mrna Level in Breast Cancer Is Associated With Hif1α Gene Expression and Microvascular Density. BMC Research Notes, 18(1), -.
Chicago	Monjezi S, Soleimani V, Cheraghzadeh M, Ghanbari S, Adelipour M. "Cirbp Mrna Level in Breast Cancer Is Associated With Hif1α Gene Expression and Microvascular Density." BMC Research Notes 18, no. 1 (2025): -.
Harvard	Monjezi S et al. (2025) 'Cirbp Mrna Level in Breast Cancer Is Associated With Hif1α Gene Expression and Microvascular Density', BMC Research Notes, 18(1), pp. -.
Vancouver	Monjezi S, Soleimani V, Cheraghzadeh M, Ghanbari S, Adelipour M. Cirbp Mrna Level in Breast Cancer Is Associated With Hif1α Gene Expression and Microvascular Density. BMC Research Notes. 2025;18(1):-.
BibTex	@article{ author = {Monjezi S and Soleimani V and Cheraghzadeh M and Ghanbari S and Adelipour M}, title = {Cirbp Mrna Level in Breast Cancer Is Associated With Hif1α Gene Expression and Microvascular Density}, journal = {BMC Research Notes}, volume = {18}, number = {1}, pages = {-}, year = {2025} }
RIS	TY - JOUR AU - Monjezi S AU - Soleimani V AU - Cheraghzadeh M AU - Ghanbari S AU - Adelipour M TI - Cirbp Mrna Level in Breast Cancer Is Associated With Hif1α Gene Expression and Microvascular Density JO - BMC Research Notes VL - 18 IS - 1 SP - EP - PY - 2025 ER -

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