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The Role of Hypoxia-Inducible Factors in Breast Cancer Stem Cell Specification Publisher Pubmed



Karami Fath M1 ; Garousi S2 ; Mottahedi M2 ; Ghasemzadeh N3 ; Salmani K4 ; Olfati F5 ; Beit Saeed M6 ; Sotoudeh S7 ; Barati G8
Authors
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Authors Affiliations
  1. 1. Department of Cellular and Molecular Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran
  2. 2. Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  3. 3. Collin College, TX, United States
  4. 4. Department of Genetics, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
  5. 5. Department of Reproductive Health, Faculty of Nursing and Midwifery, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Faculty of Nursing and Midwifery, Abadan Islamic Azad University, Abadan, Iran
  7. 7. Faculty of Nursing and Midwifery, Guilan University of Medical Sciences, Guilan, Iran
  8. 8. Stem Cell Technology Research Center, Tehran, Iran

Source: Pathology Research and Practice Published:2023


Abstract

Breast tumor is heterogeneous cancer with high morbidity and mortality rates, particularly in developing countries. Despite new efforts to reduce the breast cancer implications, the number of newly diagnosed cases is increasing worldwide. It is believed that cancer stem cells (CSCs) are responsible for the implication of cancers including breast cancer. Although CSCs compose a small population in tumor bulks, they play a crucial role in tumor initiation, progression, metastasis, and chemotherapeutic resistance. These events are mediated by the hypoxia-inducible factor (HIF) pathway which regulates the transcription of genes involved in CSC maintenance and tumorigenesis. In this review, we discussed the mechanisms by which hypoxia- or chemotherapy-induced HIFs promote breast CSC specification. © 2023 Elsevier GmbH
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