The Expression of Gene Encoding Carbohydrate Response Element Binding Protein in Obesity and Its Relationship With Visceral Adiposity and Metabolic Syndrome

The Expression of Gene Encoding Carbohydrate Response Element Binding Protein in Obesity and Its Relationship With Visceral Adiposity and Metabolic Syndrome Publisher

Borji M¹ ; Nikroo ND² ; Yousefi Z³ ; Nourbakhsh M⁴ ; Abdolvahabi Z⁵ ; Nourbakhsh M⁴ ; Larijani B⁸ ; Razzaghyazar M^{1, 4}

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1. Metabolic Disorders Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
2. Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
3. Department of Clinical Biochemistry, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
4. Hazrat Aliasghar Children Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
5. Metabolic Diseases Research Center, Research Institute for Prevention of Non-Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran
6. Finetech of Medicine Research Center, Iran University of Medical Sciences, Tehran, Iran
7. Department of Biochemistry, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
8. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Human Gene Published:2022

Abstract

Background: Carbohydrate response element-binding protein (ChREBP) is an important regulator of carbohydrate and lipid metabolism. In this study, the aim was to investigate the expression of the CHREBP gene and its relationship with metabolic parameters and hepatic steatosis in subjects with obesity. Methods: This study was conducted on 50 patients with obesity and 50 subjects with normal weight. All participants were clinically evaluated, and the diagnosis of metabolic syndrome (MetS) was done according to the criteria stated by IDF (International Diabetes Federation). Lipid accumulation in liver was evaluated using ultrasound. Gene expression of CHREBP was assessed by real-time polymerase chain reaction (PCR) in peripheral blood mononuclear cells (PBMCs). Insulin was assayed via enzyme-linked immunosorbent assay (ELISA) method, and the homeostasis model assessment of insulin resistance (HOMA-IR) was applied for the estimation of insulin resistance (IR) status. Results: Gene expression levels of CHREBP were found to be increased in obesity. Individuals with MetS had higher expression of CHREBP in comparison to those without MetS. Moreover, CHREBP expression showed a positive correlation with BMI, weight, waist circumference, visceral adiposity index, and triglyceride levels as well as an opposite relationship with high-density lipoprotein cholesterol (HDL-C). Additionally, patients with grade 2 liver steatosis indicated a significantly higher expression of CHREBP compared with the controls. Conclusion: Our results revealed that the gene expression of CHREBP is elevated in individuals with obesity and MetS, demonstrating the possible involvement of this transcription factor in the pathogenesis of the diseases that are associated with obesity. © 2022

2. Plasma Complement C1q/Tumor Necrosis Factor-Related Protein 15 Concentration Is Associated With Polycystic Ovary Syndrome, PLoS ONE (2022)

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Hassan Aghajani (1)

Style	Citing Format
MLA	Borji M, et al.. "The Expression of Gene Encoding Carbohydrate Response Element Binding Protein in Obesity and Its Relationship With Visceral Adiposity and Metabolic Syndrome." Human Gene, vol. 33, no. , 2022, pp. -.
APA	Borji M, Nikroo ND, Yousefi Z, Nourbakhsh M, Abdolvahabi Z, Nourbakhsh M, Larijani B, Razzaghyazar M (2022). The Expression of Gene Encoding Carbohydrate Response Element Binding Protein in Obesity and Its Relationship With Visceral Adiposity and Metabolic Syndrome. Human Gene, 33(), -.
Chicago	Borji M, Nikroo ND, Yousefi Z, Nourbakhsh M, Abdolvahabi Z, Nourbakhsh M, Larijani B, Razzaghyazar M. "The Expression of Gene Encoding Carbohydrate Response Element Binding Protein in Obesity and Its Relationship With Visceral Adiposity and Metabolic Syndrome." Human Gene 33, no. (2022): -.
Harvard	Borji M et al. (2022) 'The Expression of Gene Encoding Carbohydrate Response Element Binding Protein in Obesity and Its Relationship With Visceral Adiposity and Metabolic Syndrome', Human Gene, 33(), pp. -.
Vancouver	Borji M, Nikroo ND, Yousefi Z, Nourbakhsh M, Abdolvahabi Z, Nourbakhsh M, et al.. The Expression of Gene Encoding Carbohydrate Response Element Binding Protein in Obesity and Its Relationship With Visceral Adiposity and Metabolic Syndrome. Human Gene. 2022;33():-.
BibTex	@article{ author = {Borji M and Nikroo ND and Yousefi Z and Nourbakhsh M and Abdolvahabi Z and Nourbakhsh M and Larijani B and Razzaghyazar M}, title = {The Expression of Gene Encoding Carbohydrate Response Element Binding Protein in Obesity and Its Relationship With Visceral Adiposity and Metabolic Syndrome}, journal = {Human Gene}, volume = {33}, number = {}, pages = {-}, year = {2022} }
RIS	TY - JOUR AU - Borji M AU - Nikroo ND AU - Yousefi Z AU - Nourbakhsh M AU - Abdolvahabi Z AU - Nourbakhsh M AU - Larijani B AU - Razzaghyazar M TI - The Expression of Gene Encoding Carbohydrate Response Element Binding Protein in Obesity and Its Relationship With Visceral Adiposity and Metabolic Syndrome JO - Human Gene VL - 33 IS - SP - EP - PY - 2022 ER -

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