Development of a Recombinant Camelid Specific Diabody Against the Heminecrolysin Fraction of Hemiscorpius Lepturus Scorpion

Development of a Recombinant Camelid Specific Diabody Against the Heminecrolysin Fraction of Hemiscorpius Lepturus Scorpion Publisher

Bagheri M^{1, 2} ; Babaei E² ; Shahbazzadeh D¹ ; Habibianbouhi M³ ; Alirahimi E¹ ; Kazemilomedasht F¹ ; Behdani M¹

Show Affiliations

1. Venom and Bio-Therapeutics Molecules Laboratory, Biotechnology Research Center, Tehran, Iran
2. Department of Biology, School of Natural Sciences, University of Tabriz, Tabriz, Iran
3. National Cell Bank of Iran, Pasteur Institute of Iran, Tehran, Iran

Source: Toxin Reviews Published:2017

Abstract

Scorpion sting is one of the most important problems in public health practice in many countries. Khuzestan yellow scorpion, scientifically known as Hemiscorpius lepturus, belongs to the family Hemiscorpidae, and is one of the most common and dangerous scorpions in Iran. Hemiscorpius lepturus scorpion has potentially cytotoxic venom. The first treatment for scorpion envenoming is horse antisera. Due to their unique characteristics, camels have been considered as an important source for antiserum and monoclonal antibody (Nanobody) production. In the previous study, we reported a specific nanobody against the hemolytic fraction (heminecrolysin) of Hemiscorpius lepturus venom. In the present study, a recombinant diabody was constructed and produced by fusion of two nanobodies. Results from in vitro and in vivo assays showed that the diabody has a promising ability to neutralize venom activity. © 2016 Informa UK Ltd, trading as Taylor & Francis Group.

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Style	Citing Format
MLA	Bagheri M, et al.. "Development of a Recombinant Camelid Specific Diabody Against the Heminecrolysin Fraction of Hemiscorpius Lepturus Scorpion." Toxin Reviews, vol. 36, no. 1, 2017, pp. 7-11.
APA	Bagheri M, Babaei E, Shahbazzadeh D, Habibianbouhi M, Alirahimi E, Kazemilomedasht F, Behdani M (2017). Development of a Recombinant Camelid Specific Diabody Against the Heminecrolysin Fraction of Hemiscorpius Lepturus Scorpion. Toxin Reviews, 36(1), 7-11.
Chicago	Bagheri M, Babaei E, Shahbazzadeh D, Habibianbouhi M, Alirahimi E, Kazemilomedasht F, Behdani M. "Development of a Recombinant Camelid Specific Diabody Against the Heminecrolysin Fraction of Hemiscorpius Lepturus Scorpion." Toxin Reviews 36, no. 1 (2017): 7-11.
Harvard	Bagheri M et al. (2017) 'Development of a Recombinant Camelid Specific Diabody Against the Heminecrolysin Fraction of Hemiscorpius Lepturus Scorpion', Toxin Reviews, 36(1), pp. 7-11.
Vancouver	Bagheri M, Babaei E, Shahbazzadeh D, Habibianbouhi M, Alirahimi E, Kazemilomedasht F, et al.. Development of a Recombinant Camelid Specific Diabody Against the Heminecrolysin Fraction of Hemiscorpius Lepturus Scorpion. Toxin Reviews. 2017;36(1):7-11.
BibTex	@article{ author = {Bagheri M and Babaei E and Shahbazzadeh D and Habibianbouhi M and Alirahimi E and Kazemilomedasht F and Behdani M}, title = {Development of a Recombinant Camelid Specific Diabody Against the Heminecrolysin Fraction of Hemiscorpius Lepturus Scorpion}, journal = {Toxin Reviews}, volume = {36}, number = {1}, pages = {7-11}, year = {2017} }
RIS	TY - JOUR AU - Bagheri M AU - Babaei E AU - Shahbazzadeh D AU - Habibianbouhi M AU - Alirahimi E AU - Kazemilomedasht F AU - Behdani M TI - Development of a Recombinant Camelid Specific Diabody Against the Heminecrolysin Fraction of Hemiscorpius Lepturus Scorpion JO - Toxin Reviews VL - 36 IS - 1 SP - 7 EP - 11 PY - 2017 ER -

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