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The Effectiveness of Melissa Officinalis Lversus Citalopram on Quality of Life of Menopausal Women With Sleep Disorder: A Randomized Double-Blind Clinical Trial Publisher Pubmed



Shirazi M1, 2 ; Jalalian MN2 ; Abed M3 ; Ghaemi M4
Authors
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Authors Affiliations
  1. 1. Maternal, Fetal and Neonatal Research Centre, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Obstetrics and Gynecology, Yas Hospital, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Gynecology and Obstetrics, School of Medicine, Alborz University of Medical Sciences, Alborz, Iran
  4. 4. Valie-Asr Reproductive Health Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Revista Brasileira de Ginecologia e Obstetricia Published:2021


Abstract

Objective a he present study aimed to assess the effect of Melissa Officinalis L. (a combination of lemon balm with fennel fruit extract) compared with citalopram and placebo on the quality of life of postmenopausal women with sleep disturbance. Methods a he present study is a randomized, double-blind, placebo clinical trial among 60 postmenopausal women with sleep disturbance who were referred to a university hospital from 2017 to 2019. The participants were randomized to receive M. Officinalis L. (500 mg daily), citalopram (30 mg) or placebo once daily for 8 weeks. The Menopause-Specific Quality of Life (MENQOL) questionnaire was self-completed by each participant at baseline and after 8 weeks of the intervention and was compared between groups. Results a he mean for all MENQOL domain scores were significantly improved in the M. Officinalis L. group compared with citalopram and placebo (p < 0.001). The mean ± standard deviation (SD) after 8 weeks in the M. Officinalis L., citalopram and placebo groups was 2.2 ± 0.84 versus 0.56 ± 0.58 versus 0.36 ± 0.55 in the vasomotor (p < 0.001), 1.02 ± 0.6 versus 0.28 ± 0.2 versus 0.17 ± 0.1 in the psychomotor-social (p < 0.001), 0.76 ± 0.4 versus 0.25 ± 0.1 versus 0.11 ± 0.1 in the physical and 2.3 ± 1.0 versus 0.35 ± 0.5 versus 0.41 ± 0.5 in the sexual domain, respectively. Conclusions a he results revealed that M. Officinalis L. may be recommended for improving the quality of life of menopausal women with sleep disturbance. Trial registration a he present study was registered by the name Comparison of the efficacy of citalopram and compound of Asperugo procumbens and foeniculum vulgare in treatment of menopausal disorders with the code IRCT2013072714174N1 in the Iranian Registry of Clinical Trials (IRCT). © 2021 Georg Thieme Verlag. All rights reserved.
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