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Liposomes, New Carriers for Delivery of Genes and Anticancer Drugs: A Systematic Review Publisher Pubmed



Salari N1 ; Rasoulpoor S2 ; Valipour E3 ; Mansouri K2 ; Bartina Y4 ; Dokaneheifard S5 ; Mohammadi M6 ; Abam F2
Authors
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Authors Affiliations
  1. 1. Department of Biostatistics, School of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran
  2. 2. Department of Medical Biology, Medical Biology Research Centre, Kermanshah University of Medical Sciences, Kermanshah, Iran
  3. 3. Department of Medical Genetics, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Translation Studies, Faculty of Literature, Istanbul University, Istanbul, Turkey
  5. 5. Department of Human Genetics, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, United States
  6. 6. Department of Nursing, School of Nursing and Midwifery, Kermanshah University of Medical Sciences, Kermanshah, Iran

Source: Anti-Cancer Drugs Published:2022


Abstract

Today, nanoscience has grown and developed in various fields of medicine and treatment, including cancer treatment. Currently, the existing treatments, including chemotherapy and radiotherapy, cause side effects that are unpleasant to the patient. Due to the fact that anticancer drugs cause severe and widespread side effects, liposomes are considered as new drug carriers to minimize the untimely destruction of the drug when it is delivered to the target tissue and to prevent the side effects of toxic drugs. This systematic review study examined the importance of using liposomes as new drug carriers for the delivery of genes and anticancer drugs. The articles published in English in the databases of Google scholar, WoS, PubMed, Embase, Scopus and science direct were reviewed. According to the results of this study, a new targeted nanosystem has been used for loading and delivering anticancer drugs, genes and controlled drug release which has a significant therapeutic effect compared to the same amount of free drug. In general, liposomal systems have been considered because of their capability in preserving the effect of the drug along with reducing the side effects and toxicity of the drug, especially in the case of anticancer drugs. Accumulation of the drug in a target tissue which results in a reduction of the drug entry into other tissues is the main reason for reducing the side effects of these drugs. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.
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