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Association of Nlrp3 Single Nucleotide Polymorphisms With Ulcerative Colitis: A Case-Control Study Publisher Pubmed



Hanaei S1 ; Sadr M1 ; Rezaei A2 ; Shahkarami S3, 4 ; Ebrahimi Daryani N5 ; Bidoki AZ6, 7 ; Rezaei N2, 8, 9
Authors
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Authors Affiliations
  1. 1. Molecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Medical Genetics Network (MeGeNe), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  5. 5. Department of Internal Medicine, Division of Gastroenterology, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. The John Curtin School of Medical Research, Australian National University, Canberra, 2601, Australia
  7. 7. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Canberra, Australia
  8. 8. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  9. 9. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Sheffield, United Kingdom

Source: Clinics and Research in Hepatology and Gastroenterology Published:2018


Abstract

Background: Ulcerative colitis (UC) is inflammatory bowel disease (IBD), characterized by chronic inflammation episodes within mucosal layer of the intestine mostly affecting colon and rectum. As the role of innate immunity in pathogenesis of disease and important role of NLRP3, the aim of this study is to investigate the association of NLRP3 SNPs with UC in Iranian patients. Methods: Blood samples from 45 UC patients and 56 healthy subjects were tested for single nucleotide polymorphisms in rs10754558, rs3806265, rs4612666, and rs35829419 of NLRP3 gene, using real-time PCR method. Results: Among the investigated SNPs, “GG” genotype of rs10754558 have been 2.48 times more common among UC patients (P = 0.04), while “CG” genotype has indicated protective effect against UC, as more frequently found in healthy subjects. Conclusion: Despite no significant association between three investigated SNPs and disease, “GG” and “CG” genotypes of rs10754558 have been significantly associated with disease. © 2017 Elsevier Masson SAS
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