Single Nucleotide Polymorphisms of Ptpn22 Gene in Iranian Patients With Ulcerative Colitis

Single Nucleotide Polymorphisms of Ptpn22 Gene in Iranian Patients With Ulcerative Colitis Publisher Pubmed

Sadr M¹ ; Moazzami B² ; Soleimanifar N¹ ; Elhamian N² ; Rezaei A² ; Ebrahimi Daryani N³ ; Rezaei N^{2, 4, 5}

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1. Molecular Immunology Research Center, Childrenâ€™s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
2. Research Center for Immunodeficiencies, Childrenâ€™s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
3. Department of Gastroenterology and Hepatology, Tehran University of Medical Sciences, Tehran, Iran
4. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
5. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran

Source: Fetal and Pediatric Pathology Published:2019

Abstract

Objectives: Protein tyrosine phosphatase non-receptor type 22 gene (PTPN22) single-nucleotide polymorphisms (SNP) have been associated with a number of different autoimmune diseases. This study aimed to investigate the association of five polymorphisms of PTPN22 gene with susceptibility to ulcerative colitis (UC) in Iran. Materials and methods: A total of 67 patients diagnosed with UC (35 female and 32 male all under 18 years) and 93 healthy subjects were selected. The samples were genotyped for the, rs12760457, rs2476601, rs1310182, rs1217414, and rs33996649 in PTPN22 gene using real-time polymerase chain reaction (PCR) allelic discrimination TaqMan genotyping assays. Results: The frequencies of the rs1310182 A and G alleles, and also the AA and GG genotypes were significantly different between the patient and the control groups (p < 0.05). The carriage of G allele of rs1310182 was significantly associated with increased risk of UC (OR (95% CI) = 1.17 (0.70–1.98), p < 0.001). Moreover, the genotype GG of SNP rs1310182 was significantly associated with UC (OR (95% CI) = 2.32 (1.13–4.76), p < 0.01). No association was found between other PTPN22 gene SNPs among UC patients. Conclusion: PTPN22 gene polymorphism in rs1310182 could play a crucial role in susceptibility to UC. © 2018, © 2018 Taylor & Francis Group, LLC.

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Style	Citing Format
MLA	Sadr M, et al.. "Single Nucleotide Polymorphisms of Ptpn22 Gene in Iranian Patients With Ulcerative Colitis." Fetal and Pediatric Pathology, vol. 38, no. 1, 2019, pp. 8-13.
APA	Sadr M, Moazzami B, Soleimanifar N, Elhamian N, Rezaei A, Ebrahimi Daryani N, Rezaei N (2019). Single Nucleotide Polymorphisms of Ptpn22 Gene in Iranian Patients With Ulcerative Colitis. Fetal and Pediatric Pathology, 38(1), 8-13.
Chicago	Sadr M, Moazzami B, Soleimanifar N, Elhamian N, Rezaei A, Ebrahimi Daryani N, Rezaei N. "Single Nucleotide Polymorphisms of Ptpn22 Gene in Iranian Patients With Ulcerative Colitis." Fetal and Pediatric Pathology 38, no. 1 (2019): 8-13.
Harvard	Sadr M et al. (2019) 'Single Nucleotide Polymorphisms of Ptpn22 Gene in Iranian Patients With Ulcerative Colitis', Fetal and Pediatric Pathology, 38(1), pp. 8-13.
Vancouver	Sadr M, Moazzami B, Soleimanifar N, Elhamian N, Rezaei A, Ebrahimi Daryani N, et al.. Single Nucleotide Polymorphisms of Ptpn22 Gene in Iranian Patients With Ulcerative Colitis. Fetal and Pediatric Pathology. 2019;38(1):8-13.
BibTex	@article{ author = {Sadr M and Moazzami B and Soleimanifar N and Elhamian N and Rezaei A and Ebrahimi Daryani N and Rezaei N}, title = {Single Nucleotide Polymorphisms of Ptpn22 Gene in Iranian Patients With Ulcerative Colitis}, journal = {Fetal and Pediatric Pathology}, volume = {38}, number = {1}, pages = {8-13}, year = {2019} }
RIS	TY - JOUR AU - Sadr M AU - Moazzami B AU - Soleimanifar N AU - Elhamian N AU - Rezaei A AU - Ebrahimi Daryani N AU - Rezaei N TI - Single Nucleotide Polymorphisms of Ptpn22 Gene in Iranian Patients With Ulcerative Colitis JO - Fetal and Pediatric Pathology VL - 38 IS - 1 SP - 8 EP - 13 PY - 2019 ER -

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