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Association of Parvovirus B19 and Myocarditis/Dilated Cardiomyopathy: A Systematic Review and Meta-Analysis Publisher Pubmed



Khatami A1, 2 ; Razizadeh MH1 ; Ghadirali M3 ; Yazdani S4 ; Bahadory S5 ; Soleimani A6
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Authors Affiliations
  1. 1. Department of Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
  2. 2. Non-communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran
  3. 3. Department of Virology, School of Public Health, Tehran University of Medical Sciences, Iran
  4. 4. Department of Cardiology, School of Medicine, Alborz University of Medical Sciences, Iran
  5. 5. Department of Parasitology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
  6. 6. Department of Infectious Diseases, School of Medicine, Alborz University of Medical Sciences, Iran

Source: Microbial Pathogenesis Published:2022


Abstract

Background: The potential association between Parvovirus B19 and heart disease has been controversial. The aim of the present study was to report the prevalence of B19 in myocarditis and dilated cardiomyopathy (DCM) as well as measure the statistical association between them. Methods: Our systematic search was carried out to retrieve published articles between January 2000 and March 2021 using three major databases: PubMed, Scopus, and Web of Science, as well as the Google Scholar search engine. The overall prevalence of HAV, pooled odds ratio, and heterogeneity were estimated by comprehensive meta-analysis (V2.2, Biostat) software. Results: The overall prevalence results in myocarditis and DCM were 23.7% (95% CI: 18.7%–29.5%) and 34.1% (95% CI: 23.8%–46.1%) respectively; in addition, the overall OR for B19 and myocarditis was 4.317 (95% CI, 1.831–10.180) versus 1.163 (95% CI: 0.706–1.916) for B19 and DCM. Conclusion: Our findings have shown a significant association between Parvovirus B19 and myocarditis with a high prevalence. In the case of DCM, no significant association was found while the prevalence of the virus was relatively high. © 2021 Elsevier Ltd
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