The Association Between Sleep Duration and Risk of Abnormal Lipid Profile: A Systematic Review and Meta-Analysis Publisher



Abdurahman AA¹ ; Bule M² ; Shabbidar S³ ; Rezaei S^{3, 4} ; Djafarian K⁵ Show Affiliations
Source: Obesity Medicine Published:2020

Abstract

Aims: The aim of this systematic review and meta-analysis is to assess the association between sleep duration and risk of abnormal lipid profile. Main methods: PubMed, ISI Web of Science and Scopus were searched up to June 2016. Study-specific odds ratios (ORs) were pooled using a random-effects model. The protocol number of the study is PROSPERO 2016: CRD42016043919. A total of 13 articles including 83,037 participants were included in the meta-analysis. Key findings: The pooled adjusted odds ratio (AOR) revealed that long sleep duration was significantly associated with the risk of high total cholesterol (TC) (AOR, 0.93; 95% CI, 0.87–0.99). However, neither short sleep nor long sleep duration was significantly associated with the risk of high triglycerides (TG), high Low-Density Lipoprotein-cholesterol (LDL-C) and low High-Density Lipoprotein-cholesterol (HDL-C). In the subgroup analysis based on different durations of sleep (≥8–9 h, ≥9–10 h, and ≥10 h) revealed, there was a dose-response relation observed with low HDL-c, high TC and high TG. Significance: This review revealed that reliable evidence remained about the link between sleep duration and risk of abnormal lipid profile. Therefore, further large-scale well designed prospective studies should be warranted. © 2020 Elsevier Ltd