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Communication Between Stromal and Hematopoietic Stem Cell by Exosomes in Normal and Malignant Bone Marrow Niche Publisher Pubmed



Niazi V1 ; Parseh B2 ; Ahani M1 ; Karami F1 ; Gilanchi S3 ; Atarodi K4 ; Soufi M5 ; Soleimani M5 ; Ghafourifard S6 ; Taheri M7 ; Zali H1, 8
Authors

Source: Biomedicine and Pharmacotherapy Published:2020


Abstract

Extracellular vesicles (EVs) have been regarded as important tools for cell-cell communication. They act as carriers for the transfer of various molecules such as genes, proteins and miRNA. EVs shift and transfer their ingredients to target cells in an active form. These particles have prominent roles in modulation of bone marrow (BM) niche; therefore they can regulate proliferation, differentiation, and other properties of hematopoietic stem cells (HSCs) and hematopoietic progenitor cells (HPCs). This review discusses the different roles of EVs on BM niche; HPCs fate regulation and downstream effects of them on HSCs. Moreover, cellular and molecular mechanisms of BM microenvironment cross-talking are explained in healthy and malignant settings. © 2020
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