The Effects of Omega-3 Polyunsaturated Fatty Acids Supplementation in Pregnancy, Lactation, and Infancy: An Umbrella Review of Meta-Analyses of Randomized Trials

The Effects of Omega-3 Polyunsaturated Fatty Acids Supplementation in Pregnancy, Lactation, and Infancy: An Umbrella Review of Meta-Analyses of Randomized Trials Publisher Pubmed

Firouzabadi FD¹ ; Shabbidar S¹ ; Jayedi A¹

Show Affiliations

1. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran

Source: Pharmacological Research Published:2022

Abstract

We aimed to perform an umbrella review of systematic reviews and meta-analyses (SRMAs) of randomized clinical trials (RCT) of the effects of long-chain omega-3 fatty acid supplementation in pregnancy, lactation, and infancy. We searched PubMed, Scopus, and Web of Science to November 2020. Two independent investigators extracted the information, evaluated the methodological quality of SRMAs using A Measurement Tool to Assess Systematic Reviews-2 (AMSTAR2), and rated the certainty of evidence using the Grades of Recommendation, Assessment, Development and Evaluation (GRADE) approach. Either a fixed-effects or a random-effects model was used to recalculate the effect sizes and 95%CIs, depending on the number of trials. Overall, 28 SRMAs of RCTs, reporting 124 outcomes from 672 RCTs with 273,523 participants were considered eligible for the present umbrella review. Our results demonstrated evidence of moderate to high certainty that omega-3 supplementation reduced the risk of pre-eclampsia and low-birth weight and improved head circumference when used in pregnant women, and reduced severe retinopathy of prematurity and cholestasis when used in infancy. There were also favorable effects on preterm delivery, pre-natal and post-partum depression, glycemic control and inflammation markers in pregnant women, and sensitization to peanuts, positive skin prick tests, anthropometric measures, language development, visual acuity, and duration of ventilation in infants (GRADE = low). Our findings suggested that omega-3 supplementation during pregnancy can exert favorable effects against pre-eclampsia, low-birth weight, pre-term delivery, and post-partum depression, and can improve anthropometric measures, immune system, and visual activity in infants and cardiometabolic risk factors in pregnant mothers. © 2022 Elsevier Ltd

Related Docs

View other Related Docs

1. Dietary Inflammatory Index and the Risk of Non-Communicable Chronic Disease and Mortality: An Umbrella Review of Meta-Analyses of Observational Studies, Critical Reviews in Food Science and Nutrition (2023)

2. The Effects of Resveratrol Supplementation in Patients With Type 2 Diabetes, Metabolic Syndrome, and Nonalcoholic Fatty Liver Disease: An Umbrella Review of Meta-Analyses of Randomized Controlled Trials, American Journal of Clinical Nutrition (2021)

3. Nutritional Interventions for Exercise-Induced Muscle Damage: An Umbrella Review of Systematic Reviews and Meta-Analyses of Randomized Trials, Nutrition Reviews (2024)

4. Effects of a Low Fodmap Diet on the Symptom Management of Patients With Irritable Bowel Syndrome: A Systematic Umbrella Review With the Meta-Analysis of Clinical Trials, Food and Function (2024)

5. The Effects of Dietary Nitrate on Blood Pressure and Vascular Health: An Umbrella Review and Updated Meta-Analysis and Meta-Regression, Journal of Functional Foods (2024)

6. Nutritional Interventions in Adult Patients With Irritable Bowel Syndrome: An Umbrella Review of Systematic Reviews and Meta-Analyses of Randomized Clinical Trials, Nutrition Reviews (2025)

7. Efficacy and Safety of Omega-3 Fatty Acids Supplementation for Anxiety Symptoms: A Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials, BMC Psychiatry (2024)

8. The Nordic Diet and the Risk of Non-Communicable Chronic Disease and Mortality: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies, Critical Reviews in Food Science and Nutrition (2022)

Experts (# of related papers)

View all Related Experts

Sakineh Shab-Bidar (59)

Hamed Mohammadi (32)

Style	Citing Format
MLA	Firouzabadi FD, Shabbidar S, Jayedi A. "The Effects of Omega-3 Polyunsaturated Fatty Acids Supplementation in Pregnancy, Lactation, and Infancy: An Umbrella Review of Meta-Analyses of Randomized Trials." Pharmacological Research, vol. 177, no. , 2022, pp. -.
APA	Firouzabadi FD, Shabbidar S, Jayedi A (2022). The Effects of Omega-3 Polyunsaturated Fatty Acids Supplementation in Pregnancy, Lactation, and Infancy: An Umbrella Review of Meta-Analyses of Randomized Trials. Pharmacological Research, 177(), -.
Chicago	Firouzabadi FD, Shabbidar S, Jayedi A. "The Effects of Omega-3 Polyunsaturated Fatty Acids Supplementation in Pregnancy, Lactation, and Infancy: An Umbrella Review of Meta-Analyses of Randomized Trials." Pharmacological Research 177, no. (2022): -.
Harvard	Firouzabadi FD, Shabbidar S, Jayedi A (2022) 'The Effects of Omega-3 Polyunsaturated Fatty Acids Supplementation in Pregnancy, Lactation, and Infancy: An Umbrella Review of Meta-Analyses of Randomized Trials', Pharmacological Research, 177(), pp. -.
Vancouver	Firouzabadi FD, Shabbidar S, Jayedi A. The Effects of Omega-3 Polyunsaturated Fatty Acids Supplementation in Pregnancy, Lactation, and Infancy: An Umbrella Review of Meta-Analyses of Randomized Trials. Pharmacological Research. 2022;177():-.
BibTex	@article{ author = {Firouzabadi FD and Shabbidar S and Jayedi A}, title = {The Effects of Omega-3 Polyunsaturated Fatty Acids Supplementation in Pregnancy, Lactation, and Infancy: An Umbrella Review of Meta-Analyses of Randomized Trials}, journal = {Pharmacological Research}, volume = {177}, number = {}, pages = {-}, year = {2022} }
RIS	TY - JOUR AU - Firouzabadi FD AU - Shabbidar S AU - Jayedi A TI - The Effects of Omega-3 Polyunsaturated Fatty Acids Supplementation in Pregnancy, Lactation, and Infancy: An Umbrella Review of Meta-Analyses of Randomized Trials JO - Pharmacological Research VL - 177 IS - SP - EP - PY - 2022 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract