Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Omega-3 Supplementation and Outcomes of Heart Failure: A Systematic Review of Clinical Trials Publisher Pubmed



Nomali M1 ; Heidari ME2 ; Ayati A3 ; Tayebi A4 ; Shevchuk O5 ; Mohammadrezaei R6 ; Navid H7 ; Khayyatzadeh SS8, 9 ; Palii S10 ; Valizade Shiran F11 ; Khorasanian AS12 ; Veysi Z13 ; Jamalzehi A14 ; Lesani A15 Show All Authors
Authors
  1. Nomali M1
  2. Heidari ME2
  3. Ayati A3
  4. Tayebi A4
  5. Shevchuk O5
  6. Mohammadrezaei R6
  7. Navid H7
  8. Khayyatzadeh SS8, 9
  9. Palii S10
  10. Valizade Shiran F11
  11. Khorasanian AS12
  12. Veysi Z13
  13. Jamalzehi A14
  14. Lesani A15
  15. Assari G16
  16. Khani S17
  17. Hassanpour K18
  18. Gerami H8, 19
Show Affiliations
Authors Affiliations
  1. 1. Department of Epidemiology and Biostatistics, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Sue & Bill Gross School of Nursing, University of California Irvine, Irvine, CA, United States
  3. 3. Research Center for Advanced Technologies in Cardiovascular Medicine, Cardiovascular Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Cardiovascular Research Center, Alborz University of Medical Sciences, Karaj, Iran
  5. 5. Department of Pharmacology and Clinical Pharmacology, Horbachevsky Ternopil National Medical University, Ternopil, Ukraine
  6. 6. Fellowship of Advanced Heart Failure and Transplantation, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Fellowship of Advanced Heart Failure and Transplantation, Cardiovascular Research Institute, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
  8. 8. Nutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  9. 9. Department of Nutrition, Faculty of Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  10. 10. Department of Pharmacology and Clinical Pharmacology, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine
  11. 11. Ravar Hospital, Kerman University of Medical Sciences, Kerman, Iran
  12. 12. Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran
  13. 13. Department of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  14. 14. Department of Nutrition, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
  15. 15. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
  16. 16. Department of Nutrition, Food Sciences Research Center, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
  17. 17. Department of Food and Nutritional Sciences, University of Reading, United Kingdom
  18. 18. School of Medicine, Student Research Committee, Hamadan University of Medical Sciences, Hamadan, Iran
  19. 19. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Medicine (United States) Published:2024


Abstract

Backgrounds: Omega-3 supplements are endorsed for heart failure (HF) patients to reduce hospitalizations and mortality, offering anti-inflammatory and cardioprotective benefits. Methods: A comprehensive search was conducted in various databases until November 2022. Eligible studies included clinical trials on patients with HF. Data extraction covered study details, omega-3 specifics, outcomes, and limitations. The JADAD scale was used to assess the risk of bias in randomized controlled trials. Results: The review process involved 572 records from database searches, resulting in 19 studies after eliminating duplicates and screening. These studies assessed the impact of omega-3 on various clinical outcomes, such as mortality, hospitalization, cardiac function, and quality of life. Studied duration varied from weeks to years. Omega-3 supplementation demonstrated potential benefits such as improved heart function, reduced inflammation, and decreased risk of cardiovascular events. Conclusion: Omega-3 supplementation could benefit heart disease treatment, potentially reducing therapy duration and improving outcomes. Starting omega-3 supplementation for HF patients seems favorable. © 2024 Lippincott Williams and Wilkins. All rights reserved.
Related Docs
1. Dietary Intake, Biomarkers and Supplementation of Fatty Acids and Risk of Coronary Events: A Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials and Prospective Observational Studies, Critical Reviews in Food Science and Nutrition (2023)
2. Foxp3, Rorγt and Il-10 Cytokine Profile in Chronic Heart Failure, Bratislava Medical Journal (2017)
Experts (# of related papers)
View all Related Experts
Nima Rezaei (1)
Ali Akbar Amirzargar (1)