Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
A Systematic Review on the Role of Environmental Toxicants in Stem Cells Aging Publisher Pubmed



Hodjat M1 ; Rezvanfar MA1 ; Abdollahi M1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Dept. of Toxicology and Pharmacology, Faculty of Pharmacy, and Pharmaceutical Sci. Res. Center(PSRC), Endocrinology and Metabolism Research Center (EMRC), Toxicology and Poisoning Research Center (TPRC), Tehran University of Medical Sciences (TUMS), Tehran, 1417614411, Iran

Source: Food and Chemical Toxicology Published:2015


Abstract

Stem cells are an important target for environmental toxicants. As they are the main source for replenishing of organs in the body, any changes in their normal function could affect the regenerative potential of organs, leading to the appearance of age-related disease and acceleration of the aging process. Environmental toxicants could exert their adverse effect on stem cell function via multiple cellular and molecular mechanisms, resulting in changes in the stem cell differentiation fate and cell transformation, and reduced self-renewal capacity, as well as induction of stress-induced cellular senescence. The present review focuses on the effect of environmental toxicants on stem cell function associated with the aging process. We categorized environmental toxicants according to their preferred molecular mechanism of action on stem cells, including changes in genomic, epigenomic, and proteomic levels and enhancing oxidative stress. Pesticides, tobacco smoke, radiation and heavy metals are well-studied toxicants that cause stem cell dysfunction via induction of oxidative stress. Transgenerational epigenetic changes are the most important effects of a variety of toxicants on germ cells and embryos that are heritable and could affect health in the next several generations. A better understanding of the underlying mechanisms of toxicant-induced stem cell aging will help us to develop therapeutic intervention strategies against environmental aging. Meanwhile, more efforts are required to find the direct in vivo relationship between adverse effect of environmental toxicants and stem cell aging, leading to organismal aging. © 2015 Elsevier Ltd.
Related Docs
View other Related Docs
1. Growing Knowledge of Using Embryonic Stem Cells As a Novel Tool in Developmental Risk Assessment of Environmental Toxicants, Life Sciences (2016)
2. Molecular Evidence on the Protective Effect of Ellagic Acid on Phosalone-Induced Senescence in Rat Embryonic Fibroblast Cells, Food and Chemical Toxicology (2017)
3. A State-Of-The-Art Review on the Micrornas Roles in Hematopoietic Stem Cell Aging and Longevity, Cell Communication and Signaling (2023)
4. Effects of Methyl Mercury on the Activity and Gene Expression of Mouse Langerhans Islets and Glucose Metabolism, Food and Chemical Toxicology (2016)
5. Biochemical Evidence on the Potential Role of Methyl Mercury in Hepatic Glucose Metabolism Through Inflammatory Signaling and Free Radical Pathways, Journal of Cellular Biochemistry (2019)
6. The Relationship Between Mercury Exposure and Epigenetic Alterations Regarding Human Health, Risk Assessment and Diagnostic Strategies, Journal of Trace Elements in Medicine and Biology (2019)
7. Alteration of Hepatocellular Antioxidant Gene Expression Pattern and Biomarkers of Oxidative Damage in Diazinon-Induced Acute Toxicity in Wistar Rat: A Time–Course Mechanistic Study, EXCLI Journal (2018)
8. Opportunities and Challenges in Stem Cell Aging, Advances in Experimental Medicine and Biology (2021)
Experts (# of related papers)
View all Related Experts
Mohammad Abdollahi (53)
Maryam Baeeri (25)
Other Related Docs
9. Mechanistic Assessment of Cadmium Toxicity in Association With the Functions of Estrogen Receptors in the Langerhans Islets, Iranian Journal of Basic Medical Sciences (2019)
10. Review of Endocrine Disorders Associated With Environmental Toxicants and Possible Involved Mechanisms, Life Sciences (2016)
11. Pesticides: An Update of Human Exposure and Toxicity, Archives of Toxicology (2017)
12. Immunotoxicity of Mercury: Pathological and Toxicological Effects, Journal of Environmental Science and Health - Part C Environmental Carcinogenesis and Ecotoxicology Reviews (2017)
13. Biochemical and Molecular Evidence on the Role of Vaspin in Early Detection of the Insulin Resistance in a Rat Model of High-Fat Diet and Use of Diazinon, Toxicology (2019)
14. The Link of Organophosphorus Pesticides With Neurodegenerative and Neurodevelopmental Diseases Based on Evidence and Mechanisms, Toxicology (2018)
15. Assessment of Benzene Induced Oxidative Impairment in Rat Isolated Pancreatic Islets and Effect on Insulin Secretion, Environmental Toxicology and Pharmacology (2015)
16. Epigenotoxicity: A Danger to the Future Life, Journal of Environmental Science and Health - Part A Toxic/Hazardous Substances and Environmental Engineering (2023)
17. Α-Lipoic Acid Prevents Senescence, Cell Cycle Arrest, and Inflammatory Cues in Fibroblasts by Inhibiting Oxidative Stress, Pharmacological Research (2019)
18. Dual Targeting of Tnf- Α and Free Radical Toxic Stress As a Promising Strategy to Manage Experimental Polycystic Ovary, Pharmaceutical Biology (2016)
19. Epigenetic Biomarkers in Aging and Longevity: Current and Future Application, Life Sciences (2024)
20. Protective Effect of Selenium-Based Medicines on Toxicity of Three Common Organophosphorus Compounds in Human Erythrocytes in Vitro, Cell Journal (2016)
21. Autophagy, Its Mechanisms and Regulation: Implications in Neurodegenerative Diseases, Ageing Research Reviews (2017)
22. Hospital Centered Surveillance of Births in Gaza, Palestine, 2011–2017 and Heavy Metal Contamination of the Mothers Reveals Long-Term Impact of Wars, Reproductive Toxicology (2019)
23. Protective Effects of Cerium Oxide and Yttrium Oxide Nanoparticles on Reduction of Oxidative Stress Induced by Sub-Acute Exposure to Diazinon in the Rat Pancreas, Journal of Trace Elements in Medicine and Biology (2017)
24. On the Protection by the Combination of Ceo2 Nanoparticles and Sodium Selenite on Human Lymphocytes Against Chlorpyrifos-Induced Apoptosis in Vitro, Cell Journal (2015)
25. Environmental Toxicants, Incidence of Degenerative Diseases, and Therapies From the Epigenetic Point of View, Archives of Toxicology (2017)
26. A Review of the Protective Effect of Melatonin in Pesticide-Induced Toxicity, Expert Opinion on Drug Metabolism and Toxicology (2017)
27. Electrophysiological and Molecular Mechanisms of Protection by Iron Sucrose Against Phosphine-Induced Cardiotoxicity: A Time Course Study, Toxicology Mechanisms and Methods (2015)
28. The Protective Role of Melatonin in Chemotherapy‐Induced Nephrotoxicity: A Review of Non-Clinical Studies, Expert Opinion on Drug Metabolism and Toxicology (2018)
29. Blockage of Both the Extrinsic and Intrinsic Pathways of Diazinon-Induced Apoptosis in Patu Cells by Magnesium Oxide and Selenium Nanoparticles, International Journal of Nanomedicine (2016)
30. Health Risks Associated With the Pharmaceuticals in Wastewater, DARU# Journal of Pharmaceutical Sciences (2017)
31. Effect of Styrene Exposure on Plasma Parameters, Molecular Mechanisms and Gene Expression in Rat Model Islet Cells, Environmental Toxicology and Pharmacology (2017)
32. Biochemical and Molecular Evidences on the Protection by Magnesium Oxide Nanoparticles of Chlorpyrifos-Induced Apoptosis in Human Lymphocytes, Journal of Research in Medical Sciences (2015)
33. Urokinase-Plasminogen Activator Protects Periodontal Ligament Fibroblast From Oxidative Induced-Apoptosis and Dna Damage, Journal of Periodontal Research (2018)
34. Regulation of Aging and Oxidative Stress Pathways in Aged Pancreatic Islets Using Alpha-Lipoic Acid, Molecular and Cellular Biochemistry (2018)
35. A Comprehensive Review of Pesticides and the Immune Dysregulation: Mechanisms, Evidence and Consequences, Toxicology Mechanisms and Methods (2015)
36. A Systematic Review of the Molecular Mechanisms of Uranium-Induced Reproductive Toxicity, Inflammation and Allergy - Drug Targets (2015)
37. Bisphenol A: What Lies Beneath Its Induced Diabetes and the Epigenetic Modulation?, Life Sciences (2018)
38. Cinnamon, a Promising Prospect Towards Alzheimer's Disease, Pharmacological Research (2018)
39. Antioxidant Genes, the Insecticide Diazinon, and Toxicity, Toxicology: Oxidative Stress and Dietary Antioxidants (2020)
40. Recent Updates in Imperative Natural Compounds for Healthy Brain and Nerve Function: A Systematic Review of Implications for Multiple Sclerosis, Current Drug Targets (2017)
41. Oral Administration of Acrylamide Worsens the Inflammatory Responses in the Airways of Asthmatic Mice Through Agitation of Oxidative Stress in the Lungs, Frontiers in Immunology (2020)
42. Biosensors and Their Applications in Detection of Organophosphorus Pesticides in the Environment, Archives of Toxicology (2017)
43. Mitochondrial Contribution to Cell Death, Mitochondrial Metabolism: An Approach to Disease Management (2021)
44. Targeting the Tlr4 Signaling Pathway by Polyphenols: A Novel Therapeutic Strategy for Neuroinflammation, Ageing Research Reviews (2017)
45. Epigenetic Modifications Associated With Pathophysiological Effects of Lead Exposure, Journal of Environmental Science and Health - Part C Environmental Carcinogenesis and Ecotoxicology Reviews (2019)
46. The Molecular Mechanisms of Liver and Islets of Langerhans Toxicity by Benzene and Its Metabolite Hydroquinone in Vivo and in Vitro, Toxicology Mechanisms and Methods (2015)
47. Dna Methylation and Histone Acetylation Patterns in Cultured Bovine Adipose Tissue-Derived Stem Cells (Badscs), Cell Journal (2015)
48. Molecular Mechanisms of Action of Styrene Toxicity in Blood Plasma and Liver, Environmental Toxicology (2017)
49. On the Mechanism of Genotoxicity of Ethephon on Embryonic Fibroblast Cells, Toxicology Mechanisms and Methods (2017)
50. Role of Antioxidants and Phytochemicals on Acrylamide Mitigation From Food and Reducing Its Toxicity, Journal of Food Science and Technology (2015)