Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! By
Clinical Utility of Fmri in Evaluating of Lsd Effect on Pain-Related Brain Networks in Healthy Subjects Publisher



Faramarzi A1 ; Fooladi M2 ; Yousef Pour M3 ; Khodamoradi E4 ; Chehreh A5 ; Amiri S6 ; Shavandi M7 ; Sharini H1
Authors

Source: Heliyon Published:2024


Abstract

Objective: We aimed to evaluate the effect of Lysergic acid diethylamide (LSD) on the pain neural network (PNN) in healthy subjects using functional magnetic resonance imaging (fMRI). Methods: Twenty healthy volunteers participated in a balanced-order crossover study, receiving intravenous administration of LSD and placebo in two fMRI scanning sessions. Brain regions associated with pain processing were analyzed by amplitude of low-frequency fluctuation (ALFF), independent component analysis (ICA), functional connectivity and dynamic casual modeling (DCM). Results: ALFF analysis demonstrated that LSD effectively relieves pain due to modulation in the neural network associated with pain processing. ICA analysis showed more active voxels in anterior cingulate cortex (ACC), thalamus (THL)-left, THL-right, insula cortex (IC)-right, parietal operculum (PO)-left, PO-right and frontal pole (FP)-right in the placebo session than the LSD session. There were more active voxels in FP-left and IC-left in the LSD session compared to the placebo session. Functional brain connectivity was observed between THL-left and PO-right and between PO-left with FP-left, FP-right and IC-left in the placebo session. In the LSD session, functional connectivity of PO-left with FP-left and FP-right was observed. The effective connectivity between left anterior insula cortex (lAIC)-lAIC, lAIC-dorsolateral prefrontal cortex (dlPFC) and secondary somatosensory cortex (SII)-dlPFC were significantly different. Finally, the correlation between fMRI biomarkers and clinical pain criteria was calculated. Conclusion: This study enhances our understanding of the LSD effect on the architecture and neural behavior of pain in healthy subjects and provides great promise for future research in the field of cognitive science and pharmacology. © 2024
Related Docs
View other Related Docs
1. Identification of the Pain Process by Cold Stimulation: Using Dynamic Causal Modeling of Effective Connectivity in Functional Near-Infrared Spectroscopy (Fnirs), IRBM (2019)
2. Altered Amplitude of Low-Frequency Fluctuations of Rs-Fmri Signal Followed by Rtms Analgesic Effects in Non-Specific Chronic Low Back Pain (Clbp) Patients, Journal of Biomedical Physics and Engineering (2024)
3. Computer-Aided Classifying and Characterizing of Methamphetamine Use Disorder Using Resting-State Eeg, Cognitive Neurodynamics (2019)
Experts (# of related papers)
View all Related Experts
Mohammad Ali Oghabian (3)
Mohammadreza Nazemzadeh (2)
Other Related Docs
4. The Analysis of Spontaneous Electroencephalogram (Eeg) in Chronic Low Back Pain Patients Compared With Healthy Subjects, Medical Journal of the Islamic Republic of Iran (2023)
5. Dlpfc Stimulation Alters Large-Scale Brain Networks Connectivity During a Drug Cue Reactivity Task: A Tdcs-Fmri Study, Frontiers in Systems Neuroscience (2022)
6. Fmri As an Outcome Measure in Clinical Trials: A Systematic Review in Clinicaltrials.Gov, Brain and Behavior (2021)
7. Central Nervous System Changes in Pelvic Inflammation/Pain Patients, Current Bladder Dysfunction Reports (2019)
8. A Novel Approach for Extracting Functional Brain Networks Involved in Mesial Temporal Lobe Epilepsy Based on Self Organizing Maps, Informatics in Medicine Unlocked (2022)
9. Investigating the Relationship Between Subjective Drug Craving and Temporal Dynamics of the Default Mode Network, Executive Control Network, and Salience Network in Methamphetamine Dependents Using Rsfmri, Progress in Biomedical Optics and Imaging - Proceedings of SPIE (2016)
10. White Matter Correlates of Cognition: A Diffusion Magnetic Resonance Imaging Study, Behavioural Brain Research (2025)
11. Brain Structural and Functional Abnormalities in Patients With Tension-Type Headache: A Systematic Review of Magnetic Resonance Imaging Studies, Journal of Neuroscience Research (2024)
12. Locally Estimated Hemodynamic Response Function and Activation Detection Sensitivity in Heroin-Cue Reactivity Study, Basic and Clinical Neuroscience (2016)
13. Simultaneous Electroencephalography-Functional Magnetic Resonance Imaging for Assessment of Human Brain Function, Frontiers in Systems Neuroscience (2022)
14. Characterization of Brain Functional Connectivity in Treatment-Resistant Depression, Progress in Neuro-Psychopharmacology and Biological Psychiatry (2021)
15. Disrupted Resting-State Brain Functional Network in Methamphetamine Abusers: A Brain Source Space Study by Eeg, PLoS ONE (2019)
16. Functional Neuroimaging for Addiction Medicine: From Mechanisms to Practical Considerations, Progress in Brain Research (2016)
17. A Preliminary Study of the Efficacy of Transcranial Direct Current Stimulation in Trigeminal Neuralgia, Frontiers in Human Neuroscience (2022)
18. Structural and Functional Reorganization of the Brain in Migraine Without Aura, Frontiers in Neurology (2019)
19. Research Paper: Changes in Effective Connectivity Network Patterns in Drug Abusers, Treated With Different Methods, Basic and Clinical Neuroscience (2017)
20. Some Points to Consider in a Task-Based Fmri Study: A Guideline for Beginners, Frontiers in Biomedical Technologies (2020)