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What Are the Effects of N-Acetylcysteine Supplementation on Anthropometric Indices? a Systematic Review and Meta-Analysis of Clinical Trials Publisher



Zarei M1 ; Zarezadeh M2, 3 ; Khademi F4 ; Adeli S4 ; Abbaszade F4 ; Nikpayam O2, 3 ; Janmohammadi P5 ; Mohammadzadeh Honarvar N1 ; Hazhir Karzar N6 ; Ghoreishi Z3 ; Ostadrahimi A3
Authors
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Authors Affiliations
  1. 1. Department of Cellular and Molecular Nutrition, School of Nutrition Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
  3. 3. Nutrition Research Center, Department of Clinical Nutrition, Faculty of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran
  4. 4. Department of Biochemistry and Diet Therapy, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
  5. 5. Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States

Source: PharmaNutrition Published:2020


Abstract

Background: N-acetyl cystatin (NAC) potentially can contribute to weight changes due to its antioxidant activities. Aim of the review: we carried out a systematic review and meta-analysis of randomized clinical trials in order to examine whether NAC consumption can result in any changes in anthropometric indices. Methods: Using appropriate keywords, we searched online databases of PubMed-Medline, SCOPUS, Web of Science, Embase databases and Google Scholar, published for relevant articles up to Nov 2019. Random-effect model was employed to report weighted mean differences. Sensitivity and subgroup analyses were carried out. Results: A number of 7 eligible studies were identified. The results indicated no significant effect of NAC on BMI, weight and WC [(SMD=-0.08 Kg/m2 ; CI: -0.25, 0.08; P = 0.335, I2 = 0.0 %, P = 0.967), (SMD= -0.38 Kg; 95 % CI: -2.11, 2.87; P = 0.766, I2 = 0.0 %, P = 0.691) and (SMD= -0.22 Cm; 95 % CI: 0.52, 0.08; p = 0.153, I2 = 0.0 %, P = 0.826), respectively. No effect of sensitivity and subgroup analyses were observed. Conclusion: There was no significant effect of NAC supplementation on obesity indices. As far as we assessed anthropometric factors mainly as the secondary outcome in these studies rather than the main outcome, more specific trials are suggested to assess this relationship precisely. © 2020 Elsevier B.V.
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