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The Effect of Green Coffee Extract Supplementation on Anthropometric Measures in Adults: A Comprehensive Systematic Review and Dose-Response Meta-Analysis of Randomized Clinical Trials Publisher Pubmed



Asbaghi O1 ; Sadeghian M2, 3 ; Rahmani S4 ; Mardani M1 ; Khodadost M5, 6 ; Maleki V7 ; Pirouzi A8 ; Talebi S9 ; Sadeghi O8, 10, 11
Authors
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Authors Affiliations
  1. 1. Nutritional Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran
  2. 2. Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  3. 3. Department of Nutrition, School of Allied Medical Sciences, Ahvaz Jundishapur University of Medical Science, Ahvaz, Iran
  4. 4. Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Department of Epidemiology, School of Public Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  6. 6. Department of Epidemiology, School of Public Health, Iran University of Medical Sciences, Tehran, Iran
  7. 7. Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
  8. 8. Gerash University of Medical Sciences, Gerash, Iran
  9. 9. Student Research Committee, Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
  10. 10. Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran
  11. 11. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran

Source: Complementary Therapies in Medicine Published:2020


Abstract

Background and aim: Two meta-analyses summarized data on the effects of green coffee extract (GCE) supplementation on anthropometric measures. However, the accuracy of those meta-analyses is uncertain due to several methodological limitations. Therefore, we aimed to conduct a comprehensive systematic review and dose-response meta-analysis to summarize all available evidence on the effects of GCE supplementation on anthropometric measures by considering the main limitations in the previous meta-analyses. Methods: We searched available online databases for relevant publications up to January 2020, using relevant keywords. All randomized clinical trials (RCTs) investigating the effects of GCE supplementation, compared with a control group, on anthropometric measures [including body weight, body mass index (BMI), body fat percentage, waist circumference (WC) and waist-to-hip ratio (WHR)] were included. Results: After identifying 1871 studies from our initial search, 15 RCTs with a total sample size of 897 participants were included in the systematic review and meta-analysis. We found a significant reducing effect of GCE supplementation on body weight (weighted mean difference (WMD): −1.23, 95 % CI: −1.64, −0.82 kg,P < 0.001), BMI (WMD: −0.48, 95 % CI: −0.78, −0.18 kg/m2, P = 0.001), and WC (WMD: −1.00, 95 % CI: −1.70, −0.29 cm, P = 0.006). No significant effect of GCE supplementation on body fat percentage and WHR was seen. In the dose-response analyses, there was no significant association between chlorogenic acid (CGA) dosage, as the main polyphenol in green coffee, and changes in anthropometric measures. Conclusion: We found that GCE supplementation had a beneficial effect on body weight, BMI and WC. It provides a cost-effective and safe alternative for the treatment of obesity. Additional well-designed studies are required to further confirm our findings. © 2020 Elsevier Ltd
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