Diffuse Alveolar Damage and Thrombotic Microangiopathy Are the Main Histopathological Findings in Lung Tissue Biopsy Samples of Covid-19 Patients

Diffuse Alveolar Damage and Thrombotic Microangiopathy Are the Main Histopathological Findings in Lung Tissue Biopsy Samples of Covid-19 Patients Publisher Pubmed

Sadegh Beigee F¹ ; Pourabdollah Toutkaboni M² ; Khalili N³ ; Nadji SA⁴ ; Dorudinia A² ; Rezaei M⁴ ; Askari E² ; Farzanegan B⁵ ; Marjani M⁶ ; Rafiezadeh A²

Show Affiliations

1. Lung Transplantation Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
2. Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
3. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
4. Virology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
5. Tracheal Diseases Research Center, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
6. Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Pathology Research and Practice Published:2020

Abstract

Background: Since the outbreak of the novel coronavirus disease-2019 (COVID-19) in December 2019, limited studies have investigated the histopathologic findings of patients infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Material and methods: This study was conducted on 31 deceased patients who were hospitalized for COVID-19 in a tertiary hospital in Tehran, Iran. A total of 52 postmortem tissue biopsy samples were obtained from the lungs and liver of decedents. Clinical characteristics, laboratory data, and microscopic features were evaluated. Reverse transcription polymerase chain reaction (RT-PCR) assay for SARS-CoV-2 was performed on specimens obtained from nasopharyngeal swabs and tissue biopsies. Results: The median age of deceased patients was 66 years (range, 30–87 years) and 25 decedents (81 %) were male. The average interval from symptom onset to death was 13 days (range, 6–34 days). On histopathologic examination of the lung specimens, diffuse alveolar damage and thrombotic microangiopathy were the most common findings (80 % and 60 %, respectively). Liver specimens mainly showed macrovesicular steatosis, portal lymphoplasmacytic inflammation and passive congestion. No definitive viral inclusions were observed in any of the specimens. In addition, 92 % of lung tissue samples tested positive for SARS-CoV-2 by RT-PCR. Conclusions: Further studies are needed to investigate whether SARS-CoV-2 causes direct cytopathic changes in various organs of the human body. © 2020 Elsevier GmbH

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Style	Citing Format
MLA	Sadegh Beigee F, et al.. "Diffuse Alveolar Damage and Thrombotic Microangiopathy Are the Main Histopathological Findings in Lung Tissue Biopsy Samples of Covid-19 Patients." Pathology Research and Practice, vol. 216, no. 10, 2020, pp. -.
APA	Sadegh Beigee F, Pourabdollah Toutkaboni M, Khalili N, Nadji SA, Dorudinia A, Rezaei M, Askari E, Farzanegan B, Marjani M, Rafiezadeh A (2020). Diffuse Alveolar Damage and Thrombotic Microangiopathy Are the Main Histopathological Findings in Lung Tissue Biopsy Samples of Covid-19 Patients. Pathology Research and Practice, 216(10), -.
Chicago	Sadegh Beigee F, Pourabdollah Toutkaboni M, Khalili N, Nadji SA, Dorudinia A, Rezaei M, Askari E, Farzanegan B, Marjani M, Rafiezadeh A. "Diffuse Alveolar Damage and Thrombotic Microangiopathy Are the Main Histopathological Findings in Lung Tissue Biopsy Samples of Covid-19 Patients." Pathology Research and Practice 216, no. 10 (2020): -.
Harvard	Sadegh Beigee F et al. (2020) 'Diffuse Alveolar Damage and Thrombotic Microangiopathy Are the Main Histopathological Findings in Lung Tissue Biopsy Samples of Covid-19 Patients', Pathology Research and Practice, 216(10), pp. -.
Vancouver	Sadegh Beigee F, Pourabdollah Toutkaboni M, Khalili N, Nadji SA, Dorudinia A, Rezaei M, et al.. Diffuse Alveolar Damage and Thrombotic Microangiopathy Are the Main Histopathological Findings in Lung Tissue Biopsy Samples of Covid-19 Patients. Pathology Research and Practice. 2020;216(10):-.
BibTex	@article{ author = {Sadegh Beigee F and Pourabdollah Toutkaboni M and Khalili N and Nadji SA and Dorudinia A and Rezaei M and Askari E and Farzanegan B and Marjani M and Rafiezadeh A}, title = {Diffuse Alveolar Damage and Thrombotic Microangiopathy Are the Main Histopathological Findings in Lung Tissue Biopsy Samples of Covid-19 Patients}, journal = {Pathology Research and Practice}, volume = {216}, number = {10}, pages = {-}, year = {2020} }
RIS	TY - JOUR AU - Sadegh Beigee F AU - Pourabdollah Toutkaboni M AU - Khalili N AU - Nadji SA AU - Dorudinia A AU - Rezaei M AU - Askari E AU - Farzanegan B AU - Marjani M AU - Rafiezadeh A TI - Diffuse Alveolar Damage and Thrombotic Microangiopathy Are the Main Histopathological Findings in Lung Tissue Biopsy Samples of Covid-19 Patients JO - Pathology Research and Practice VL - 216 IS - 10 SP - EP - PY - 2020 ER -

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