Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Prevalence of Thyroid Dysfunction Among Iranian Older Adults: A Cross-Sectional Study Publisher Pubmed



Mirahmad M1 ; Mansour A1 ; Moodi M2 ; Safkhani E3 ; Haghpanah V1 ; Asili P1 ; Fakhrzadeh H4 ; Payab M5 ; Ebrahimpur M4 ; Khorashadi M2 ; Khodabakhshi H6, 7 ; Esmaeili AA8 ; Sharifzadeh G9 ; Zarban A10 Show All Authors
Authors
  1. Mirahmad M1
  2. Mansour A1
  3. Moodi M2
  4. Safkhani E3
  5. Haghpanah V1
  6. Asili P1
  7. Fakhrzadeh H4
  8. Payab M5
  9. Ebrahimpur M4
  10. Khorashadi M2
  11. Khodabakhshi H6, 7
  12. Esmaeili AA8
  13. Sharifzadeh G9
  14. Zarban A10
  15. Sharifi F4
  16. Sajjadijazi SM1
Show Affiliations
Authors Affiliations
  1. 1. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Social Determinants of Health Research Center, Birjand University of Medical Sciences, Birjand, Iran
  3. 3. Department of Internal Medicine, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Elderly Health Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Non-Comunicable Disease Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Gerontology, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
  7. 7. Iranian Research Center of Aging, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
  8. 8. Department of Psychiatry, School of Medicine Medical Toxicology & Drug Abuse Research Center, Birjand University of Medical Sciences, Birjand, Iran
  9. 9. Department of Epidemiology and Biostatistics, School of Health, Social Determinants of Health Research Center, Birjand University of Medical Sciences, Birjand, Iran
  10. 10. Department of Clinical Biochemistry, School of Medicine, Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran

Source: Scientific Reports Published:2023


Abstract

There is limited data on the prevalence of thyroid dysfunction in the older population. This study aimed to determine the prevalence of thyroid dysfunction among a sample of Iranian older adults. A cross-sectional analysis of older adults who aged 60 years and over was conducted. A total of 363 subjects were randomly selected from Birjand longitudinal aging study (BLAS) cohort study. Serum thyroid-stimulating hormone (TSH) level, total thyroxine (T4) and total triiodothyronine (T3) were measured by the enzyme-linked immunosorbent assay (ELISA). Based on thyroid function tests and history of taking medicines used to treat thyroid disorders, participants were classified into the following groups: euthyroid, overt/subclinical hypothyroidism, and overt/subclinical hyperthyroidism. Subsequently, the crude and World Health Organization (WHO) age-standardized prevalence were estimated for different thyroid function categories. A total of 171 men and 192 women, aged 60–94 years, were randomly selected. The crude prevalence of total hypothyroidism was 22.31% (subclinical [18.46%], overt [3.86%]), and that of hyperthyroidism was 1.66% (subclinical [1.38%], overt [0.28%]). The crude prevalence of total thyroid dysfunction was, therefore, 23.97%. A female preponderance was noticed in both total (P-value = 0.035) and overt (P-value = 0.035) hypothyroidism. An increasing trend with age was noticed in the prevalence of total hypothyroidism (P-value = 0.049). Age-standardized prevalence of total hypothyroidism and hyperthyroidism was 26.63% (95% confidence interval [CI] 20.58–33.69%) and 1.11% (95% CI 0.49–2.51%), respectively. A considerable proportion of our study population demonstrated evidence of thyroid dysfunction, particularly subclinical hypothyroidism. Our findings highlight the importance of further investigation of thyroid disorders among older Iranian adults. © 2023, The Author(s).
Related Docs
1. Epidemiology of Hyperthyroidism in Iran: A Systematic Review and Meta-Analysis, Journal of Diabetes and Metabolic Disorders (2018)
2. Increased Prevalence of Thyroid Dysfunction in Tehran – Hamrah Study, BMC Endocrine Disorders (2023)
3. An Estimation of Clinical Hyperthyroidism Prevalence in the National and Sub-National Levels in Iran Using Claims Data, Iranian Journal of Diabetes and Metabolism (2020)
4. Burden Attributable to Iodine Deficiency in Iran From 1990 to 2019: Findings From Global Burden of Disease Study, Journal of Preventive Medicine and Hygiene (2024)
5. The Association Between Dental Caries, Periodontal Diseases, and Tooth Loss With Diabetes Mellitus Among the Elderly Population, Journal of Diabetes and Metabolic Disorders (2024)
6. Association of Prolonged Occupational Co-Exposures to Electromagnetic Fields, Noise, and Rotating Shift Work With Thyroid Hormone Levels, Ecotoxicology and Environmental Safety (2024)
7. Natural Course of Euthyroidism and Clues for Early Diagnosis of Thyroid Dysfunction: Tehran Thyroid Study, Thyroid (2017)
8. Frequency of Positive Thyroid Peroxidase Antibody and Its Related Factors During Pregnancy in Pregnant Women Referring to the Centers Under Coverage of Shahid Beheshti University of Medical Sciences, 2013-2016, Iranian Journal of Obstetrics# Gynecology and Infertility (2018)
Experts (# of related papers)
View all Related Experts
Farshad Sharifi (3)
Farshad Farzadfar (2)