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Association Between T3, T4, and Tsh Hormones Proportion and Toxoplasma Gondii Anti-Igg Seroprevalence in Patients Suffering From Clinical and Drug-Controlled Thyroid Dysfunctions in Southeastern Iran; [Guneydogu Iran'da Klinik Ve Ilac Kontrollu Tiroid Fonksiyon Bozuklugu Olan Hastalarda T3, T4 Ve Tsh Hormonlari Orani Ile Toxoplasma Gondii Anti-Igg Seroprevalansi Arasindaki Iliski] Publisher



Raissi V1 ; Alizadeh G1 ; Bayat F1 ; Akhlaghi E2 ; Getso M3 ; Raiesi O4 ; Abdollahi A5 ; Ibrahim A6 ; Akbari S7 ; Navi Z1 ; Etemadi S8
Authors
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Authors Affiliations
  1. 1. Tehran University of Medical Sciences, Department of Medical Parasitology and Mycology, School of Public Health, Iran
  2. 2. Kerman University of Medical Sciences, Department of Parasitology and Mycology, School of Medicine, Iran
  3. 3. Bayero University, Department of Medical Microbiology and Parasitology, College of Health Sciences, Nigeria
  4. 4. Ilam University of Medical Sciences, Department of Parasitology, School of Allied Medical Sciences, Iran
  5. 5. Islamic Azad University, Department of Surgery, Science and Research, Branch, Iran
  6. 6. University of Sadat City (GEBRI, USC), Genetic Engineering and Biotechnology Research Institute, Egypt
  7. 7. Isfahan University of Medical Sciences, Department of Parasitology and Mycology, School of Medicine, Iran
  8. 8. Zahedan University of Medical Sciences, Resistant Tuberculosis Institute, Infectious Diseases and Tropical Medicine Research Center, Iran

Source: Turk Hijyen ve Deneysel Biyoloji Dergisi Published:2021


Abstract

Objective: Toxoplasma gondii is an important agent responsible for many hormonal and behavioral disorders in humans. The main objective of this study was to evaluate the hypothesis that ‘T. gondii infection interferes with thyroid hormones secretion or thyroid drug treatment'. Methods: This is a cross-sectional study that involved 249 patients suffering from thyroid dysfunctions, divided into 3 groups: hypothyroidism (n=107), hyperthyroidism (n=96), and drug-controlled thyroid disorders (n=91), referred to Seyedoshohada Kerman private clinic. Serum samples were tested for thyroid-stimulating hormone (TSH), triiodothyronine (T3), and thyroxine (T4) along with Toxoplasma anti-IgG using ELISA technique. Demographic information was collected using a demographic Results: The seroprevalence of Toxoplasma gondii IgG antibodies among patients with hypothyroidism, hyperthyroidism, and drug-controlled thyroid disorders was 22.4%, 19.8%, and 22% respectively. The mean value of thyroid hormones of positive T. gondii samples in hypothyroidism, hyperthyroidism, and drug-controlled thyroid disorders was TSH=7.95, T3=1.12, T4=2.36; TSH=0.14, T3=1.42, T4=7.85; and TSH=2.75, T3=1.12, T4=1.45 respectively. The seropositivity of Toxoplasma gondii infection was 40.4% among individuals with a history of contact with pets and 26.3% among the rural dwellers. Conclusion: There was no significant difference between T. gondii infection among the three study groups. A comparison of serum levels of thyroid hormones between infected and non-infected individuals in the above-mentioned groups illustrated that latent toxoplasmosis wasn't significantly associated with thyroid hormones secretion. Also, contact with pets and the rural lifestyle has a positive association with T. gondii seroprevalence. © 2021. All Rights Reserved.
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