Association of Maternal Blood Lead Concentration With the Risk of Small for Gestational Age: A Dose-Response Meta-Analysis Publisher Pubmed



Sezavar AH¹ ; Pourhassan B² ; Kakavandi NR¹ ; Hooshangi Shayeste MR¹ ; Abyadeh M³ Show Affiliations
Source: Archives of Environmental and Occupational Health Published:2022

Abstract

In spite of growing evidence for the negative effect of lead, knowledge about the dose-response relationship of maternal blood lead level (BLL) and the risk of small for gestational age (SGA) is limited. We performed this meta-analysis to evaluate the dose-response relation between maternal BLL and the risk of SGA. A systematic search through Embase and PubMed was performed. Odds ratios (ORs) and 95% confidence intervals (95% CI) were calculated. The nonlinear and linear relationships between maternal BLL and the risk of SGA were also investigated. Results from 51,065 patients showed a significant association between maternal BLL and risk of SGA in highest versus lowest analysis (OR: 1.54; 95% CI: 1.12–2.10, p = 0.007). While there was no association in linear dose-response (OR: 1.02; 95% CI: 1.00–1.04, p = 0.021) meta-analysis, a direct relationship was observed in the nonlinear model (nonlinearity p < 0.001). Results of this dose-response meta-analysis showed that maternal BLL higher than ∼ 0.3 µg/dL is directly associated with the risk of SGA. © 2021 Taylor & Francis Group, LLC.