Biocontrol Treatment: Application of Bdellovibrio Bacteriovorus Hd100 Against Burn Wound Infection Caused by Pseudomonas Aeroginosa in Mice

Biocontrol Treatment: Application of Bdellovibrio Bacteriovorus Hd100 Against Burn Wound Infection Caused by Pseudomonas Aeroginosa in Mice Publisher Pubmed

Tajabadi FH¹ ; Karimian SM² ; Mohsenipour Z¹ ; Mohammadi S¹ ; Salehi M³ ; Sattarzadeh M⁵ ; Fakhari S⁴ ; Momeni M⁵ ; Dahmardehei M⁵ ; Feizabadi MM^{1, 6}

Show Affiliations

1. Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
2. Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
3. Department of Infectious Disease, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
4. Department of Pathology, School of Medicine, Arak University of Medical Sciences, Arak, Iran
5. Burn Research Center, Iran University of Medical Sciences, Tehran, Iran
6. Thoracic Research Center, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran

Source: Burns Published:2023

Abstract

Owing to the high level of resistance to various antibiotics in bacteria causing burn wound infections, the alternative therapeutics is highly demanded. Bdellovibrio and like organisms (BALOs) seem to be a superb choice. In the present study, Bdellovibrio bacteriovorus HD100 was selected for treating burn wound infection caused by Pseudomonas aeruginosa strain PAO1 in a mouse model. In this experiment, two treatments, meropenem as antibiotic and B. bacteriovorus, were employed. Histopathology indicated an accelerated healing rate in both treatments in comparison with the control. Moreover, quantitative reverse transcription PCR (qRT-PCR) was applied to investigate the expression of tnf-α (tumor necrosis factor alpha), pdgf (platelet-derived growth factor), tgf-β1 (transforming growth factor beta1), ifn-γ (interferon gamma), vegf (vascular endothelial group factor), and col1 (collagen type 1). The results demonstrated that treating burn wound areas with Bdellovibrio not only decrease the inflammatory phase period, but also may improve the characteristics of proliferative phases of wound healing. In addition, a significant difference was explored between the two treatment groups in the regulation of all genes, except for pdgf revealed a significant up regulation in both treatment groups. The results disclose that Bdellovibrio attenuates P. aeruginosa in burn wounds infections and improves the wound healing process. © 2022 Elsevier Ltd and International Society of Burns Injuries

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Style	Citing Format
MLA	Tajabadi FH, et al.. "Biocontrol Treatment: Application of Bdellovibrio Bacteriovorus Hd100 Against Burn Wound Infection Caused by Pseudomonas Aeroginosa in Mice." Burns, vol. 49, no. 5, 2023, pp. 1181-1195.
APA	Tajabadi FH, Karimian SM, Mohsenipour Z, Mohammadi S, Salehi M, Sattarzadeh M, Fakhari S, Momeni M, Dahmardehei M, Feizabadi MM (2023). Biocontrol Treatment: Application of Bdellovibrio Bacteriovorus Hd100 Against Burn Wound Infection Caused by Pseudomonas Aeroginosa in Mice. Burns, 49(5), 1181-1195.
Chicago	Tajabadi FH, Karimian SM, Mohsenipour Z, Mohammadi S, Salehi M, Sattarzadeh M, Fakhari S, Momeni M, Dahmardehei M, Feizabadi MM. "Biocontrol Treatment: Application of Bdellovibrio Bacteriovorus Hd100 Against Burn Wound Infection Caused by Pseudomonas Aeroginosa in Mice." Burns 49, no. 5 (2023): 1181-1195.
Harvard	Tajabadi FH et al. (2023) 'Biocontrol Treatment: Application of Bdellovibrio Bacteriovorus Hd100 Against Burn Wound Infection Caused by Pseudomonas Aeroginosa in Mice', Burns, 49(5), pp. 1181-1195.
Vancouver	Tajabadi FH, Karimian SM, Mohsenipour Z, Mohammadi S, Salehi M, Sattarzadeh M, et al.. Biocontrol Treatment: Application of Bdellovibrio Bacteriovorus Hd100 Against Burn Wound Infection Caused by Pseudomonas Aeroginosa in Mice. Burns. 2023;49(5):1181-1195.
BibTex	@article{ author = {Tajabadi FH and Karimian SM and Mohsenipour Z and Mohammadi S and Salehi M and Sattarzadeh M and Fakhari S and Momeni M and Dahmardehei M and Feizabadi MM}, title = {Biocontrol Treatment: Application of Bdellovibrio Bacteriovorus Hd100 Against Burn Wound Infection Caused by Pseudomonas Aeroginosa in Mice}, journal = {Burns}, volume = {49}, number = {5}, pages = {1181-1195}, year = {2023} }
RIS	TY - JOUR AU - Tajabadi FH AU - Karimian SM AU - Mohsenipour Z AU - Mohammadi S AU - Salehi M AU - Sattarzadeh M AU - Fakhari S AU - Momeni M AU - Dahmardehei M AU - Feizabadi MM TI - Biocontrol Treatment: Application of Bdellovibrio Bacteriovorus Hd100 Against Burn Wound Infection Caused by Pseudomonas Aeroginosa in Mice JO - Burns VL - 49 IS - 5 SP - 1181 EP - 1195 PY - 2023 ER -

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