Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Photodisinfection Effects of Silver Sulfadiazine Nanoliposomes Doped-Curcumin on Acinetobacter Baumannii: A Mouse Model Publisher Pubmed



Pourhajibagher M1 ; Partoazar A2 ; Alaeddini M1 ; Etemadmoghadam S1 ; Bahador A3
Authors
Show Affiliations
Authors Affiliations
  1. 1. Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Oral Microbiology Laboratory, Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Nanomedicine Published:2020


Abstract

Aim: To evaluate the antimicrobial effects of photoexcited silver sulfadiazine nanoliposomes (AgSD-NLs) doped by curcumin (AgSD-NLs@Cur) on Acinetobacter baumannii. Materials & methods: Following characterization, the cytotoxic and hemolytic activities of AgSD-NLs@Cur were evaluated. The antimicrobial activities of AgSD-NLs@Cur-mediated antimicrobial photodynamic therapy (aPDT) were determined. Histopathological examination of the burn wound sites of infected mice treated with photoexcited AgSD-NLs@Cur was assessed. Results: No significant cytotoxic and hemolytic activities were observed. There was a decrease in the Acinetobacter baumannii count in planktonic and biofilm forms and the gene expression level using AgSD-NLs@Cur-aPDT (p < 0.05). Histopathological analysis indicated the epidermis developed markedly and the bacterial load decreased significantly after aPDT. Conclusion: Photoexcited AgSD-NLs@Cur has an antimicrobial potential against A. baumannii. © 2020 Future Medicine Ltd.
Related Docs
View other Related Docs
1. Contribution of Antimicrobial Photo-Sonodynamic Therapy in Wound Healing: An in Vivo Effect of Curcumin-Nisin-Based Poly (L-Lactic Acid) Nanoparticle on Acinetobacter Baumannii Biofilms, BMC Microbiology (2022)
2. Exploring Photoactivated Disinfection-Induced Bystander Effects on Microbial Biofilms of Aggregatibacter Actinomycetemcomitans, Infectious Disorders - Drug Targets (2021)
3. The Anti-Biofilm Capability of Nano-Emodin-Mediated Sonodynamic Therapy on Multi-Species Biofilms Produced by Burn Wound Bacterial Strains, Photodiagnosis and Photodynamic Therapy (2021)
4. Modulation of Virulence in Enterococcus Faecalis Cells Surviving Antimicrobial Photodynamic Inactivation With Reduced Graphene Oxide-Curcumin: An Ex Vivo Biofilm Model, Photodiagnosis and Photodynamic Therapy (2020)
5. Evaluation of Antimicrobial Effects of Photo-Sonodynamic Antimicrobial Chemotherapy Based on Nano-Micelle Curcumin on Virulence Gene Expression Patterns in Acinetobacter Baumannii, Infectious Disorders - Drug Targets (2022)
6. Carnosine-Graphene Oxide Conjugates Decorated With Hydroxyapatite As Promising Nanocarrier for Icg Loading With Enhanced Antibacterial Effects in Photodynamic Therapy Against Streptococcus Mutans, Journal of Photochemistry and Photobiology B: Biology (2018)
7. Investigation of Arginine A-Specific Cysteine Proteinase Gene Expression Profiling in Clinical Porphyromonas Gingivalis Isolates Against Photokilling Action of the Photo-Activated Disinfection, Lasers in Medical Science (2018)
8. Growth Rate and Biofilm Formation Ability of Clinical and Laboratory-Evolved Colistin-Resistant Strains of Acinetobacter Baumannii, Frontiers in Microbiology (2018)
Experts (# of related papers)
View all Related Experts
Abbas Bahador (48)
Maryam Pourhajibagher (47)
Other Related Docs
9. Expression Patterns of Oxyr Induced by Oxidative Stress From Porphyromonas Gingivalis in Response to Photo-Activated Disinfection, Infection and Drug Resistance (2018)
10. Enhancement of Hypericin Nanoparticle-Mediated Sonoinduced Disruption of Biofilm and Persister Cells of Streptococcus Mutans by Dermcidin-Derived Peptide Dcd-1L, Photodiagnosis and Photodynamic Therapy (2023)
11. Real-Time Quantitative Reverse Transcription-Pcr Analysis of Expression Stability of Aggregatibacter Actinomycetemcomitans Fimbria-Associated Gene in Response to Photodynamic Therapy, Photodiagnosis and Photodynamic Therapy (2017)
12. Biofilm Inhibition of Multidrug-Resistant Pseudomonas Aeruginosa Using Green-Synthesized Silver Nanoparticles and Colistin, Scientific Reports (2025)
13. Exploring Different Photosensitizers to Optimize Elimination of Planktonic and Biofilm Forms of Enterococcus Faecalis From Infected Root Canal During Antimicrobial Photodynamic Therapy, Photodiagnosis and Photodynamic Therapy (2018)
14. Potentiation Effects of Antimicrobial Photodynamic Therapy on Quorum Sensing Genes Expression: A Promising Treatment for Multi-Species Bacterial Biofilms in Burn Wound Infections, Photodiagnosis and Photodynamic Therapy (2020)
15. Antimicrobial Activity of Photodynamic Therapy in Combination With Colistin Against a Pan-Drug Resistant Acinetobacter Baumannii Isolated From Burn Patient, Photodiagnosis and Photodynamic Therapy (2017)
16. In Vitro Antibacterial Activity of Photoactivated Flavonoid Glycosides Against Acinetobacter Baumannii, AMB Express (2024)
17. Evaluation of Photodynamic Therapy Effect Along With Colistin on Pandrug-Resistant Acinetobacter Baumannii, Laser Therapy (2017)
18. The Effect of Antimicrobial Photodynamic Therapy on the Expression of Novel Methicillin Resistance Markers Determined Using Cdna-Aflp Approach in Staphylococcus Aureus, Photodiagnosis and Photodynamic Therapy (2017)
19. Antimicrobial Action of Photoactivated C-Phycocyanin Against Enterococcus Faecalis Biofilms: Attenuation of Quorum-Sensing System, Photodiagnosis and Photodynamic Therapy (2019)
20. Monitoring Gene Expression of Rcpa From Aggregatibacter Actinomycetemcomitans Versus Antimicrobial Photodynamic Therapy by Relative Quantitative Real-Time Pcr, Photodiagnosis and Photodynamic Therapy (2017)
21. In Vitro Efficacy of Antimicrobial Photodynamic Therapy With Phycocyanin and Diode Laser for the Reduction of Porphyromonas Gingivalis, Journal of Lasers in Medical Sciences (2022)
22. Prevalence and Molecular Mechanisms of Colistin Resistance in Acinetobacter Baumannii Clinical Isolates in Tehran, Iran, Acta Microbiologica et Immunologica Hungarica (2021)
23. Anti-Virulence Effect of Photoactivated Nano-Quercetin by Diode Laser on Aggregatibacter Actinomycetemcomitans, AMB Express (2025)
24. Effect of Nanomicelle Curcumin-Based Photodynamic Therapy on the Dynamics of White Spot Lesions and Virulence of Streptococcus Mutans in Patients Undergoing Fixed Orthodontic Treatment: A Randomized Double-Blind Clinical Trial, Photodiagnosis and Photodynamic Therapy (2022)
25. Photosensitizers in Antibacterial Photodynamic Therapy: An Overview, Laser Therapy (2018)
26. Antibiofilm Activity of Natural Zeolite Supported Nanozno: Inhibition of Esp Gene Expression of Enterococcus Faecalis, Nanomedicine (2019)
27. Postbiotic Mediators Derived From Lactobacillus Species Enhance Riboflavin-Mediated Antimicrobial Photodynamic Therapy for Eradication of Streptococcus Mutans Planktonic and Biofilm Growth, BMC Oral Health (2024)
28. In-Vivo Monitoring of Infectious Diseases in Living Animals Using Bioluminescence Imaging, Virulence (2018)
29. Ex Vivo Assessment of Synergic Effect of Chlorhexidine for Enhancing Antimicrobial Photodynamic Therapy Efficiency on Expression Patterns of Biofilm-Associated Genes of Enterococcus Faecalis, Photodiagnosis and Photodynamic Therapy (2018)
30. Photo-Activated Disinfection Based on Indocyanine Green Against Cell Viability and Biofilm Formation of Porphyromonas Gingivalis, Photodiagnosis and Photodynamic Therapy (2017)
31. Biocontrol Treatment: Application of Bdellovibrio Bacteriovorus Hd100 Against Burn Wound Infection Caused by Pseudomonas Aeroginosa in Mice, Burns (2023)
32. The Evaluation of Cultivable Microbiota Profile in Patients With Secondary Endodontic Infection Before and After Photo-Activated Disinfection, Photodiagnosis and Photodynamic Therapy (2017)
33. In Vitro Antibacterial Activity and Durability of a Nano-Curcumin-Containing Pulp Capping Agent Combined With Antimicrobial Photodynamic Therapy, Photodiagnosis and Photodynamic Therapy (2021)
34. Evaluation of Nano-Curcumin Effects on Expression Levels of Virulence Genes and Biofilm Production of Multidrug-Resistant Pseudomonas Aeruginosa Isolated From Burn Wound Infection in Tehran, Iran, Infection and Drug Resistance (2019)
35. Enhanced Reduction of Polymicrobial Biofilms on the Orthodontic Brackets and Enamel Surface Remineralization Using Zeolite-Zinc Oxide Nanoparticles-Based Antimicrobial Photodynamic Therapy, BMC Microbiology (2021)
36. The Relationship Between Antibiotic Resistance Phenotypes and Biofilm Formation Capacity in Clinical Isolates of Acinetobacter Baumannii, Jundishapur Journal of Microbiology (2018)
37. Analysis of Glucosyltransferase Gene Expression of Clinical Isolates of Streptococcus Mutans Obtained From Dental Plaques in Response to Sub-Lethal Doses of Photoactivated Disinfection, Photodiagnosis and Photodynamic Therapy (2018)
38. An in Vivo Evaluation of Microbial Diversity Before and After the Photo-Activated Disinfection in Primary Endodontic Infections: Traditional Phenotypic and Molecular Approaches, Photodiagnosis and Photodynamic Therapy (2018)
39. Dna-Aptamer-Nanographene Oxide As a Targeted Bio-Theragnostic System in Antimicrobial Photodynamic Therapy Against Porphyromonas Gingivalis, Scientific Reports (2022)
40. Photoactivation of Curcumin Doped Poly-Lactic-Co-Glycolic Acid Nanoparticles in Rat Model With Fixed Orthodontic Appliances, Scientific World Journal (2022)
41. The Efficacy of Photodynamic and Photothermal Therapy on Biofilm Formation of Streptococcus Mutans: An in Vitro Study, Photodiagnosis and Photodynamic Therapy (2017)
42. Antimicrobial Activity of D-Amino Acid in Combination With Photo-Sonoactivated Hypericin Nanoparticles Against Acinetobacter Baumannii, BMC Microbiology (2023)
43. Antibacterial, Antibiofilm, and Antiquorum Sensing Activities of Phytosynthesized Silver Nanoparticles Fabricated From Mespilus Germanica Extract Against Multidrug Resistance of Klebsiella Pneumoniae Clinical Strains, Journal of Basic Microbiology (2020)
44. Biofilm Formation and Antibiotic Resistance in Meticillin-Resistant and Meticillin-Sensitive Staphylococcus Aureus Isolated From Burns, Journal of Wound Care (2019)
45. Evaluation of Antimicrobial Photodynamic Therapy With Toluidine Blue Against Enterococcus Faecalis: Laser Vs Led, Photodiagnosis and Photodynamic Therapy (2020)
46. Culture-Dependent Approaches to Explore the Prevalence of Root Canal Pathogens From Endodontic Infections, Brazilian Oral Research (2017)
47. Antimicrobial Properties, Anti-Virulence Activities, and Physico-Mechanical Characteristics of Orthodontic Adhesive Containing C-Phycocyanin: A Promising Application of Natural Products; [Антимикробные Свойства, Антивирулентная Активность И Физико-Механические Характеристики Ортодонтического Клея, Содержащего С-Фикоцианин: Перспективное Применение Натуральных Продуктов], Folia Medica (2021)
48. Combinatorial Therapy of Chitosan Hydrogel-Based Zinc Oxide Nanocomposite Attenuates the Virulence of Streptococcus Mutans, BMC Microbiology (2021)
49. Prevalence of Methicillin-Resistant Staphylococcus Aureus Isolated From Burn Patients in Iran: A Systematic Review and Meta-Analysis, Journal of Global Antimicrobial Resistance (2018)
50. Modulation of the Triggered Apoptosis by Nano Emodin Transfersome-Mediated Sonodynamic Therapy on Head and Neck Squamous Cell Carcinoma Cell Lines, Photodiagnosis and Photodynamic Therapy (2021)