Predictive Factors of Successful Microdissection Testicular Sperm Extraction in Patients With Presumed Sertoli Cell-Only Syndrome



Modarresi T¹ ; Hosseinifar H¹ ; Hampa AD¹ ; Chehrazi M² ; Hosseini J¹ ; Farrahi F¹ ; Dadkhah F¹ ; Sabbaghian M¹ ; Gilani MAS^{1, 3} Show Affiliations
Source: International Journal of Fertility and Sterility Published:2015

Abstract

Background: To evaluate predictive factors of successful microdissection-testicular sperm extraction (MD-TESE) in patients with presumed Sertoli cell-only syndrome (SCOS). Materials and Methods: In this retrospective analysis, 874 men with non-obstructive azoospermia (NOA), among whom 148 individuals with diagnosis of SCOS in prior biopsy, underwent MD-TESE at Department of Andrology, Royan Institute, Tehran, Iran. The predictive values of follicle stimulating hormone (FSH), luteinizing hormone (LH), and testosterone (T) levels, testicular volume, as well as male age for retrieving testicular sperm by MD-TESE were analyzed by multiple logistic regression analysis. Results: Testicular sperm were successfully retrieved in 23.6% men with presumed SCOS. Using receiver operating characteristic (ROC) curve analysis, it was shown that sperm retrieval rate in the group of men with FSH values >15.25% was 28.9%. This was higher than the group of men with FSH ≤15.25 (11.8%). Conclusion: Sperm retrieval rate (SRR) was 23.6% in men with presumed SCOS and FSH level can be a fair predictor for SPR at MD-TESE. MD-TESE appears to be recommendable in such cases (SCOS with high FSH concentration) with reasonable results. © 2015, Int J Fertil Steril. All rights reserved.