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Relationship Between Fecal Calprotectin and Upper Endoscopy Findings in Children With Upper Gastrointestinal Symptoms Publisher



Ataee P1 ; Afrasiabi V2 ; Nikkhoo B3 ; Sani MN4, 5 ; Rahehagh R3 ; Ghaderi E6 ; Monajemzadeh M5, 7 ; Fathollahpour A2 ; Sedaghat B8 ; Kariminejhad F9 ; Parizad J5 ; Eftekhari K10
Authors
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Authors Affiliations
  1. 1. Liver and Digestive Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran
  2. 2. Department of Pediatrics, Kurdistan University of Medical Sciences, Sanandaj, Iran
  3. 3. Department of Pathology, Kurdistan University of Medical Sciences, Sanandaj, Iran
  4. 4. Department of Pediatrics, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Children’s Medical Center, Pediatrics Center of Excellence, Tehran, Iran
  6. 6. Social Determinants of Health Center, Kurdistan University of Medical Sciences, Sanandaj, Iran
  7. 7. Department of Pathology, Children’s Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran
  8. 8. Department of Pediatrics, Shariati Hospital, Social Security Organization, Isfahan, Iran
  9. 9. Department of Endoscopy, Kurdistan University of Medical Sciences, Sanandaj, Iran
  10. 10. Department of Pediatrics, Bahrami Children’s Hospital, Tehran University of Medical Sciences, Tehran, Iran

Source: Iranian Journal of Pediatrics Published:2017


Abstract

Background: Chronic abdominal pain in children is a common disorder. For an accurate diagnosis of its cause, sometimes invasive diagnostic procedures such as endoscopy should be performed. Objectives: The purpose of the study was to evaluate the fecal calprotectin in children with upper gastrointestinal signs and symptoms and to compare it with endoscopic findings. Methods: A total of 131 children aged 1-14 years with upper gastrointestinal symptoms were enrolled during 2012 - 2013 at two centers. One hundred and twenty patients underwent endoscopy and biopsy. Before endoscopy, the level of calprotectin was measured by the enzyme-linked immunosorbent assay test in stool samples and the results were compared with the endoscopic and pathology findings. Results: Of the 120 children included in this study, 71 (59.2%) were males and 49 (40.8%) females with a mean age of 93.6 months. Of the 112 patients in whom biopsies were taken, 16 had esophagitis, 89 chronic gastritis (79.5%) and 57 colonization with Helicobacter pylori. Conclusions: There was a statistically significant correlation between fecal calprotectin and gastritis and severity of H. pylori infection. Fecal calprotectin level measurement can avoid unnecessary endoscopies and is also useful for evaluation of therapy response. © 2017, Growth & Development Research Center.