Identifying the Profile of Helicobacter Pylori-Negative Gastric Cancers: A Case-Only Analysis Within the Stomach Cancer Pooling (Stop) Project

Identifying the Profile of Helicobacter Pylori-Negative Gastric Cancers: A Case-Only Analysis Within the Stomach Cancer Pooling (Stop) Project Publisher Pubmed

Morais S^{1, 2, 3} ; Peleteiro B^{1, 2, 3} ; Araujo N^{1, 2, 3} ; Malekzadeh R⁴ ; Ye W⁵ ; Plymoth A⁵ ; Tsugane S⁶ ; Hidaka A⁶ ; Hamada GS⁷ ; Lopezcarrillo L⁸ ; Zaridze D⁹ ; Maximovich D⁹ ; Aragones N^{10, 11} ; Castanovinyals G^{11, 12, 13, 14} Show All Authors

Morais S^{1, 2, 3}
Peleteiro B^{1, 2, 3}
Araujo N^{1, 2, 3}
Malekzadeh R⁴
Ye W⁵
Plymoth A⁵
Tsugane S⁶
Hidaka A⁶
Hamada GS⁷
Lopezcarrillo L⁸
Zaridze D⁹
Maximovich D⁹
Aragones N^{10, 11}
Castanovinyals G^{11, 12, 13, 14}
Pakseresht M^{4, 15, 16}
Ulises Hernandezramirez R¹⁷
Lopezcervantes M¹⁸
Leja M^{19, 20, 21, 22}
Gasenko E^{20, 21, 22}
Pourfarzi F^{4, 23}
Zhang ZF²⁴
Yu GP²⁵
Derakhshan MH^{4, 26}
Pelucchi C²⁷
Negri E²⁷
La Vecchia C²⁷
Lunet N^{1, 2, 3}

Show Affiliations

1. EPIUnit - Instituto de Saude Publica, Universidade do Porto, Porto, Portugal
2. Laboratorio para a Investiga câˆ¼ao Integrativa e Translacional em Saude Populacional (ITR), Porto, Portugal
3. Departamento de Ciencias da Saude Publica e Forenses e Educacâˆ¼ao Medica, Faculdade de Medicina, Universidade do Porto, Porto, Portugal
4. Digestive Oncology Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran
5. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
6. Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan
7. Nikkei Disease Prevention Center, Sao Paulo, Brazil
8. Mexico National Institute of Public Health, Morelos, Mexico
9. Department of Epidemiology and Prevention, Russian N.N. Blokhin Cancer Research Center, Moscow, Russian Federation
10. Epidemiology Section, Public Health Division, Department of Health of Madrid, Madrid, Spain
11. CIBER Epidemiologia y Salud Publica (CIBERESP), Madrid, Spain
12. Barcelona Institute for Global Health-ISGlobal, Barcelona, Spain
13. IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain
14. Universitat Pompeu Fabra (UPF), Barcelona, Spain
15. Department of Agricultural, Food and Nutritional Sciences, University of Alberta, Edmonton, AB, Canada
16. Nutritional Epidemiology Group, Centre for Epidemiology and Biostatistics, University of Leeds, Leeds, United Kingdom
17. Department of Biostatistics, Yale School of Public Health, Yale School of Medicine, New Haven, CT, United States
18. Facultad de Medicina, UNAM, Coyoacan, Mexico
19. Digestive Diseases Centre GASTRO, Riga, Latvia
20. Institute of Clinical and Preventive Medicine, University of Latvia, Riga, Latvia
21. Faculty of Medicine, University of Latvia, Riga, Latvia
22. Riga East University Hospital, Riga, Latvia
23. Digestive Disease Research Center, Ardabil University of Medical Sciences, Ardabil, Iran
24. Department of Epidemiology, UCLA Fielding School of Public Health and Jonsson Comprehensive Cancer Center, Los Angeles, CA, United States
25. Medical Informatics Center, Peking University, Peking, China
26. Institute of Cardiovascular & Medical Sciences, University of Glasgow, Glasgow, United Kingdom
27. Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy

Source: Cancer Epidemiology Biomarkers and Prevention Published:2022

Abstract

Background: The prevalence of Helicobacter pylori-negative gastric cancer (HpNGC) can be as low as 1%, when infection is assessed using more sensitive tests or considering the presence of gastric atrophy. HpNGC may share a high-risk profile contributing to the occurrence of cancer in the absence of infection.Weestimated the proportion of HpNGC, using different criteria to define infection status, and compared HpNGC and positive cases regarding gastric cancer risk factors. Methods: Cases from 12 studies from the Stomach cancer Pooling (StoP) Project providing data on H. pylori infection status determined by serologic test were included. HpNGC was reclassified as positive (eight studies) when cases presented CagA markers (four studies), gastric atrophy (six studies), or advanced stage at diagnosis (three studies), and were compared with positive cases. A two-stage approach (random-effects models) was used to pool study-specific prevalence and adjusted odds ratios (OR). Results: Among non-cardia cases, the pooled prevalence of HpNGC was 22.4% (n = 166/853) and decreased to 7.0% (n = 55) when considering CagA status; estimates for all criteria were 21.8% (n = 276/1,325) and 6.6% (n = 97), respectively. HpNGC had a family history of gastric cancer more often [OR = 2.18; 95% confidence interval (CI), 1.03-4.61] and were current smokers (OR = 2.16; 95% CI, 0.52-9.02). Conclusion: This study found a low prevalence of HpNGC, who are more likely to have a family history of gastric cancer in first-degree relatives. © 2022 American Association for Cancer Research Inc.. All rights reserved.

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Experts (# of related papers)

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Reza Malekzadeh (26)

Sakineh Shab-Bidar (8)

Style	Citing Format
MLA	Morais S, et al.. "Identifying the Profile of Helicobacter Pylori-Negative Gastric Cancers: A Case-Only Analysis Within the Stomach Cancer Pooling (Stop) Project." Cancer Epidemiology Biomarkers and Prevention, vol. 31, no. 1, 2022, pp. 200-209.
APA	Morais S, Peleteiro B, Araujo N, Malekzadeh R, Ye W, Plymoth A, Tsugane S, Hidaka A, Hamada GS, Lopezcarrillo L, Zaridze D, Maximovich D, Aragones N, Castanovinyals G, Pakseresht M, Ulises Hernandezramirez R, Lopezcervantes M, Leja M, Gasenko E, ... Lunet N (2022). Identifying the Profile of Helicobacter Pylori-Negative Gastric Cancers: A Case-Only Analysis Within the Stomach Cancer Pooling (Stop) Project. Cancer Epidemiology Biomarkers and Prevention, 31(1), 200-209.
Chicago	Morais S, Peleteiro B, Araujo N, Malekzadeh R, Ye W, Plymoth A, Tsugane S, et al.. "Identifying the Profile of Helicobacter Pylori-Negative Gastric Cancers: A Case-Only Analysis Within the Stomach Cancer Pooling (Stop) Project." Cancer Epidemiology Biomarkers and Prevention 31, no. 1 (2022): 200-209.
Harvard	Morais S et al. (2022) 'Identifying the Profile of Helicobacter Pylori-Negative Gastric Cancers: A Case-Only Analysis Within the Stomach Cancer Pooling (Stop) Project', Cancer Epidemiology Biomarkers and Prevention, 31(1), pp. 200-209.
Vancouver	Morais S, Peleteiro B, Araujo N, Malekzadeh R, Ye W, Plymoth A, et al.. Identifying the Profile of Helicobacter Pylori-Negative Gastric Cancers: A Case-Only Analysis Within the Stomach Cancer Pooling (Stop) Project. Cancer Epidemiology Biomarkers and Prevention. 2022;31(1):200-209.
BibTex	@article{ author = {Morais S and Peleteiro B and Araujo N and Malekzadeh R and Ye W and Plymoth A and Tsugane S and Hidaka A and Hamada GS and Lopezcarrillo L and Zaridze D and Maximovich D and Aragones N and Castanovinyals G and Pakseresht M and Ulises Hernandezramirez R and Lopezcervantes M and Leja M and Gasenko E and Pourfarzi F and Zhang ZF and Yu GP and Derakhshan MH and Pelucchi C and Negri E and La Vecchia C and Lunet N}, title = {Identifying the Profile of Helicobacter Pylori-Negative Gastric Cancers: A Case-Only Analysis Within the Stomach Cancer Pooling (Stop) Project}, journal = {Cancer Epidemiology Biomarkers and Prevention}, volume = {31}, number = {1}, pages = {200-209}, year = {2022} }
RIS	TY - JOUR AU - Morais S AU - Peleteiro B AU - Araujo N AU - Malekzadeh R AU - Ye W AU - Plymoth A AU - Tsugane S AU - Hidaka A AU - Hamada GS AU - Lopezcarrillo L AU - Zaridze D AU - Maximovich D AU - Aragones N AU - Castanovinyals G AU - Pakseresht M AU - Ulises Hernandezramirez R AU - Lopezcervantes M AU - Leja M AU - Gasenko E AU - Pourfarzi F AU - Zhang ZF AU - Yu GP AU - Derakhshan MH AU - Pelucchi C AU - Negri E AU - La Vecchia C AU - Lunet N TI - Identifying the Profile of Helicobacter Pylori-Negative Gastric Cancers: A Case-Only Analysis Within the Stomach Cancer Pooling (Stop) Project JO - Cancer Epidemiology Biomarkers and Prevention VL - 31 IS - 1 SP - 200 EP - 209 PY - 2022 ER -

Style

Citing Format

MLA

Morais S, et al.. "Identifying the Profile of Helicobacter Pylori-Negative Gastric Cancers: A Case-Only Analysis Within the Stomach Cancer Pooling (Stop) Project." Cancer Epidemiology Biomarkers and Prevention, vol. 31, no. 1, 2022, pp. 200-209.

APA

Morais S, Peleteiro B, Araujo N, Malekzadeh R, Ye W, Plymoth A, Tsugane S, Hidaka A, Hamada GS, Lopezcarrillo L, Zaridze D, Maximovich D, Aragones N, Castanovinyals G, Pakseresht M, Ulises Hernandezramirez R, Lopezcervantes M, Leja M, Gasenko E, ... Lunet N (2022). Identifying the Profile of Helicobacter Pylori-Negative Gastric Cancers: A Case-Only Analysis Within the Stomach Cancer Pooling (Stop) Project. Cancer Epidemiology Biomarkers and Prevention, 31(1), 200-209.

Chicago

Morais S, Peleteiro B, Araujo N, Malekzadeh R, Ye W, Plymoth A, Tsugane S, et al.. "Identifying the Profile of Helicobacter Pylori-Negative Gastric Cancers: A Case-Only Analysis Within the Stomach Cancer Pooling (Stop) Project." Cancer Epidemiology Biomarkers and Prevention 31, no. 1 (2022): 200-209.

Harvard

Morais S et al. (2022) 'Identifying the Profile of Helicobacter Pylori-Negative Gastric Cancers: A Case-Only Analysis Within the Stomach Cancer Pooling (Stop) Project', Cancer Epidemiology Biomarkers and Prevention, 31(1), pp. 200-209.

Vancouver

Morais S, Peleteiro B, Araujo N, Malekzadeh R, Ye W, Plymoth A, et al.. Identifying the Profile of Helicobacter Pylori-Negative Gastric Cancers: A Case-Only Analysis Within the Stomach Cancer Pooling (Stop) Project. Cancer Epidemiology Biomarkers and Prevention. 2022;31(1):200-209.

BibTex

@article{ author = {Morais S and Peleteiro B and Araujo N and Malekzadeh R and Ye W and Plymoth A and Tsugane S and Hidaka A and Hamada GS and Lopezcarrillo L and Zaridze D and Maximovich D and Aragones N and Castanovinyals G and Pakseresht M and Ulises Hernandezramirez R and Lopezcervantes M and Leja M and Gasenko E and Pourfarzi F and Zhang ZF and Yu GP and Derakhshan MH and Pelucchi C and Negri E and La Vecchia C and Lunet N}, title = {Identifying the Profile of Helicobacter Pylori-Negative Gastric Cancers: A Case-Only Analysis Within the Stomach Cancer Pooling (Stop) Project}, journal = {Cancer Epidemiology Biomarkers and Prevention}, volume = {31}, number = {1}, pages = {200-209}, year = {2022} }

RIS

TY - JOUR
AU - Morais S
AU - Peleteiro B
AU - Araujo N
AU - Malekzadeh R
AU - Ye W
AU - Plymoth A
AU - Tsugane S
AU - Hidaka A
AU - Hamada GS
AU - Lopezcarrillo L
AU - Zaridze D
AU - Maximovich D
AU - Aragones N
AU - Castanovinyals G
AU - Pakseresht M
AU - Ulises Hernandezramirez R
AU - Lopezcervantes M
AU - Leja M
AU - Gasenko E
AU - Pourfarzi F
AU - Zhang ZF
AU - Yu GP
AU - Derakhshan MH
AU - Pelucchi C
AU - Negri E
AU - La Vecchia C
AU - Lunet N
TI - Identifying the Profile of Helicobacter Pylori-Negative Gastric Cancers: A Case-Only Analysis Within the Stomach Cancer Pooling (Stop) Project
JO - Cancer Epidemiology Biomarkers and Prevention
VL - 31
IS - 1
SP - 200
EP - 209
PY - 2022
ER -

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Abstract