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Association of Cardiovascular Risk Factors With Major and Minor Electrocardiographic Abnormalities: A Report From the Cross-Sectional Phase of Tehran Cohort Study Publisher



Ahmadi P1 ; Ahmadirenani S2 ; Pezeshki PS2 ; Nayebirad S2 ; Jalali A2 ; Shafiee A2 ; Ayati A2 ; Afzalian A2 ; Alaeddini F2 ; Saadat S3 ; Masoudkabir F4 ; Vasheghanifarahani A4 ; Sadeghian S2 ; Boroumand M2 Show All Authors
Authors
  1. Ahmadi P1
  2. Ahmadirenani S2
  3. Pezeshki PS2
  4. Nayebirad S2
  5. Jalali A2
  6. Shafiee A2
  7. Ayati A2
  8. Afzalian A2
  9. Alaeddini F2
  10. Saadat S3
  11. Masoudkabir F4
  12. Vasheghanifarahani A4
  13. Sadeghian S2
  14. Boroumand M2
  15. Karimi A2
  16. Pourbashash B2
  17. Hosseini K2
  18. Rosendaal FR5
Show Affiliations
Authors Affiliations
  1. 1. Department of Cardiology, Shariati Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Tehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Emergency Medicine, University of California, Irvine, Irvine, CA, United States
  4. 4. Cardiac Primary Prevention Research Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands

Source: Health Science Reports Published:2025


Abstract

Background and Aims: In the current study, we aimed to identify the association between major and minor electrocardiographic abnormalities and cardiovascular risk factors. Methods: We used the Tehran cohort study baseline data, an ongoing multidisciplinary, longitudinal study designed to identify cardiovascular disease risk factors in the adult population of Tehran. The electrocardiograms (ECGs) of 7630 Iranian adults aged 35 years and above were analyzed. ECG abnormalities were categorized into major or minor groups based on their clinical importance. Results were obtained by multivariable logistic regression and are expressed as odds ratios (ORs). Results: A total of 756 (9.9%) participants had major ECG abnormalities, while minor abnormalities were detected in 2526 (33.1%). Males comprised 45.8% of the total population, and 41.8% of them had minor abnormalities. Individuals with older age, diabetes (OR = 1.35; 95% CI: 1.11–1.64), and hypertension (OR = 2.21; 95% CI: 1.82–2.68) had an increased risk of major ECG abnormalities. In contrast, intermediate (OR = 0.69; 95% CI: 0.57–0.84) and high physical activity levels (OR = 0.66; 95% CI: 0.51–0.86) were associated with a lower prevalence of major abnormalities. Male sex, older age, hypertension, and current smoking were also associated with an increased prevalence of ECG abnormalities combined (major or minor). Conclusion: Major and minor ECG abnormalities are linked with important cardiovascular risk factors such as diabetes and hypertension. Since these abnormalities have been associated with poor outcomes, screening patients with cardiovascular risk factors with an ECG may distinguish high-risk individuals who require appropriate care and follow-up. © 2025 The Author(s). Health Science Reports published by Wiley Periodicals LLC.
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