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Palladium-Catalyzed Regioselective Direct Cyanation of Acetanilide Derivatives With K4[Fe(Cn)6] by C–H Bond Activation Publisher



Kianmehr E1 ; Faghih N1 ; Tanbakouchian A1 ; Mahdavi M2
Authors
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Authors Affiliations
  1. 1. School of Chemistry, College of Science, University of Tehran, Tehran, Iran
  2. 2. Drug Design and Development Research Center, College of Science, Tehran University of Medical Sciences, Tehran, Iran

Source: European Journal of Organic Chemistry Published:2016


Abstract

A practical, versatile, and efficient method for the palladium-catalyzed direct cyanation of readily available acetanilides with K4[Fe(CN)6] as a safe cyanating agent through C–H bond activation with excellent C2 regioselectivity was developed. This finding represents a new strategy for the synthesis of N-(2-cyanoaryl)acetamides, which are important structural motifs in natural products and pharmaceuticals. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim