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Global, Regional, and National Burden of Migraine and Tension-Type Headache, 1990–2016: A Systematic Analysis for the Global Burden of Disease Study 2016 Publisher Pubmed



Stovner LJ1 ; Nichols E2 ; Steiner TJ1, 3 ; Abdallah F4 ; Abdelalim A4 ; Alraddadi RM5 ; Ansha MG6 ; Barac A7, 8 ; Bensenor IM9 ; Doan LP11 ; Edessa D12 ; Endres M14 ; Foreman KJ2 ; Gankpe FG15, 16 Show All Authors
Authors
  1. Stovner LJ1
  2. Nichols E2
  3. Steiner TJ1, 3
  4. Abdallah F4
  5. Abdelalim A4
  6. Alraddadi RM5
  7. Ansha MG6
  8. Barac A7, 8
  9. Bensenor IM9
  10. Doan LP11
  11. Edessa D12
  12. Endres M14
  13. Foreman KJ2
  14. Gankpe FG15, 16
  15. Gopalkrishna G17
  16. Goulart AC10
  17. Gupta R18, 19
  18. Hankey GJ20
  19. Hay SI2, 21
  20. Hegazy MI4
  21. Hilawe EH22
  22. Kasaeian A23
  23. Kassa DH24
  24. Khalil I2
  25. Khang YH25
  26. Khubchandani J26
  27. Kim YJ27
  28. Kokubo Y28
  29. Mohammed MA29, 30
  30. Moradilakeh M31
  31. Nguyen HLT11
  32. Nirayo YL32
  33. Qorbani M33
  34. Ranta A34, 35
  35. Roba KT13
  36. Safiri S36
  37. Santos IS9
  38. Satpathy M38
  39. Sawhney M37
  40. Shiferaw MS12
  41. Shiue I39
  42. Smith M2
  43. Szoeke CEI40
  44. Truong NT11
  45. Venketasubramanian N42, 43
  46. Weldegwergs KG32
  47. Westerman R44
  48. Wijeratne T41, 45
  49. Tran BX46
  50. Yonemoto N47
  51. Feigin VL2, 48
  52. Vos T2
  53. Murray CJL2
Show Affiliations
Authors Affiliations
  1. 1. Neuromedicine and Movement Science, Norwegian University of Science and Technology, and Norwegian Advisory Unit on Headaches, St Olav’s Hospital, Trondheim, Norway
  2. 2. Institute for Health Metrics and Evaluation, University of Washington, Seattle, WA, United States
  3. 3. Division of Brain Sciences, Imperial College London, London, United Kingdom
  4. 4. Department of Neurology, Cairo University, Cairo, Egypt
  5. 5. Family and Community Medicine, King Abdulaziz University, Jeddah, Saudi Arabia
  6. 6. Public Health Debre Berhan University, Debre Berhan, Ethiopia
  7. 7. Clinic for Infectious and Tropical Diseases, Clinical Center of Serbia, Belgrade, Serbia
  8. 8. Faculty of Medicine, University of Belgrade, Belgrade, Serbia
  9. 9. Department of Internal Medicine, University of Sao Paulo, Sao Paulo, Brazil
  10. 10. Center for Clinical and Epidemiological Research, University of Sao Paulo, Sao Paulo, Brazil
  11. 11. Institute for Global Health Innovations, Duy Tan University, Hanoi, Viet Nam
  12. 12. School of Pharmacy, Haramaya University, Harar, Ethiopia
  13. 13. School of Nursing and Midwifery, Haramaya University, Harar, Ethiopia
  14. 14. Neurology, Charite–Universitatsmedizin Berlin, Berlin, Germany
  15. 15. Neurosurgery Department, Faculty of Medicine and Pharmacy of Fez, Fez, Morocco
  16. 16. Non-communicable Disease Department, Laboratoire d’Etudes et de Recherche-action en Sante (leras Afrique), Porto Novo, Benin
  17. 17. National Institute of Mental Health and Neurosciences, Bangalore, India
  18. 18. West Virginia Bureau for Public Health, Charleston, WV, United States
  19. 19. Health Policy, Management and Leadership West, Virginia University School of Public Health, Morgantown, WV, United States
  20. 20. Medical School, University of Western Australia, Perth, WA, Australia
  21. 21. Oxford Big Data Institute, Li Ka Shing, Centre for Health Information and Discovery, University of Oxford, Oxford, United Kingdom
  22. 22. Tigray Health Research Institute, Mekelle, Ethiopia
  23. 23. Hematology-oncology and Stem Cell Transplantation Research Center, and Hematologic Malignancies Research Center, Tehran University of Medical Sciences, Tehran, Iran
  24. 24. Department of Nursing, Debre Markos University, Debre Markos, Ethiopia
  25. 25. Department of Health Policy and Management, College of Medicine, and Institute of Health Policy and Management, Medical Research Center, Seoul National University, Seoul, South Korea
  26. 26. Department of Nutrition and Health Science, Ball State University, Muncie, IN, United States
  27. 27. School of Medicine, Xiamen University Malaysia, Sepang, Malaysia
  28. 28. Department of Preventive Cardiology, National Cerebral and Cardiovascular Center, Suita, Japan
  29. 29. Department of Public Health, Jigjiga Unviersity, Jigjiga, Ethiopia
  30. 30. University of Sydney, Sydney, NSW, Australia
  31. 31. Preventive Medicine and Public Health Research Center, Iran University of Medical Sciences, Tehran, Iran
  32. 32. Department of Clinical Pharmacy, Mekelle University, Mekelle, Ethiopia
  33. 33. Non-communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran
  34. 34. Department of Medicine, University of Otago, Wellington, New Zealand
  35. 35. Department of Neurology, Capital and Coast District Health Board, Wellington, New Zealand
  36. 36. Managerial Epidemiology Research Center, Department of Public Health, School of Nursing and Midwifery, Maragheh University of Medical Sciences, Maragheh, Iran
  37. 37. Public Health Sciences, University of North Carolina at Charlotte, Charlotte, NC, United States
  38. 38. University Grants Commission Centre of Advanced Study in Psychology, Utkal University, Bhubaneswar, India
  39. 39. Institute for Medical Epidemiology, Biometrics and Informatics, Martin Luther University Halle-Wittenberg, Halle, Germany
  40. 40. Medicine Dentistry and Health Science, University of Melbourne, Melbourne, VIC, Australia
  41. 41. Department of Medicine, University of Melbourne, St Albans, VIC, Australia
  42. 42. Raffles Neuroscience Centre, Raffles Hospital, Singapore, Singapore
  43. 43. Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
  44. 44. Competence Center of Mortality-follow-up, German National Cohort, Federal Institute for Population Research, Wiesbaden, Germany
  45. 45. Department of Psychology, La Trobe University, Melbourne, Australia
  46. 46. Department of Health Economics, Hanoi Medical University, Hanoi, Viet Nam
  47. 47. Department of Biostatistics, School of Public Health, Kyoto University, Kyoto, Japan
  48. 48. National Institute for Stroke and Applied, Neurosciences Auckland University of Technology, Auckland, New Zealand

Source: The Lancet Neurology Published:2018


Abstract

Background: Through the Global Burden of Diseases, Injuries, and Risk Factors (GBD) studies, headache has emerged as a major global public health concern. We aimed to use data from the GBD 2016 study to provide new estimates for prevalence and years of life lived with disability (YLDs) for migraine and tension-type headache and to present the methods and results in an accessible way for clinicians and researchers of headache disorders. Methods: Data were derived from population-based cross-sectional surveys on migraine and tension-type headache. Prevalence for each sex and 5-year age group interval (ie, age 5 years to ≥95 years) at different time points from 1990 and 2016 in all countries and GBD regions were estimated using a Bayesian meta-regression model. Disease burden measured in YLDs was calculated from prevalence and average time spent with headache multiplied by disability weights (a measure of the relative severity of the disabling consequence of a disease). The burden stemming from medication overuse headache, which was included in earlier iterations of GBD as a separate cause, was subsumed as a sequela of either migraine or tension-type headache. Because no deaths were assigned to headaches as the underlying cause, YLDs equate to disability-adjusted life-years (DALYs). We also analysed results on the basis of the Socio-demographic Index (SDI), a compound measure of income per capita, education, and fertility. Findings: Almost three billion individuals were estimated to have a migraine or tension-type headache in 2016: 1·89 billion (95% uncertainty interval [UI] 1·71–2·10) with tension-type headache and 1·04 billion (95% UI 1·00–1·09) with migraine. However, because migraine had a much higher disability weight than tension-type headache, migraine caused 45·1 million (95% UI 29·0–62·8) and tension-type headache only 7·2 million (95% UI 4·6–10·5) YLDs globally in 2016. The headaches were most burdensome in women between ages 15 and 49 years, with migraine causing 20·3 million (95% UI 12·9–28·5) and tension-type headache 2·9 million (95% UI 1·8–4·2) YLDs in 2016, which was 11·2% of all YLDs in this age group and sex. Age-standardised DALYs for each headache type showed a small increase as SDI increased. Interpretation: Although current estimates are based on limited data, our study shows that headache disorders, and migraine in particular, are important causes of disability worldwide, and deserve greater attention in health policy debates and research resource allocation. Future iterations of this study, based on sources from additional countries and with less methodological heterogeneity, should help to provide stronger evidence of the need for action. Funding: Bill & Melinda Gates Foundation. © 2018 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license
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