Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Global, Regional, and National Burden of Neurological Disorders During 1990–2015: A Systematic Analysis for the Global Burden of Disease Study 2015 Publisher Pubmed



Feigin VL1 ; Krishnamurthi RV1 ; Theadom AM1 ; Abajobir AA2 ; Mishra SR2, 135 ; Ahmed MB3 ; Abate KH3 ; Mengistie MA3 ; Wakayo T3 ; Abdallah F4 ; Abdulle AM5 ; Abera SF6, 7, 8 ; Mohammed KE6, 7 ; Abyu GY6, 7 Show All Authors
Authors
  1. Feigin VL1
  2. Krishnamurthi RV1
  3. Theadom AM1
  4. Abajobir AA2
  5. Mishra SR2, 135
  6. Ahmed MB3
  7. Abate KH3
  8. Mengistie MA3
  9. Wakayo T3
  10. Abdallah F4
  11. Abdulle AM5
  12. Abera SF6, 7, 8
  13. Mohammed KE6, 7
  14. Abyu GY6, 7
  15. Asgedom SW6, 7
  16. Atey TM6, 7
  17. Betsu BD6, 7
  18. Mezgebe HB6, 7
  19. Tuem KB6, 7
  20. Woldu MA6, 7, 75
  21. Aichour AN9
  22. Aichour I10
  23. Aichour MT11
  24. Akinyemi RO12, 13
  25. Alabed S14
  26. Alraddadi R15
  27. Alvisguzman N16
  28. Amare AT17, 18
  29. Ansari H19
  30. Anwari P20
  31. Arnlov J21, 22
  32. Fereshtehnejad S21
  33. Weiderpass E21, 211, 212, 213
  34. Havmoeller R21
  35. Asayesh H23
  36. Avilaburgos L24
  37. Avokpaho EFGA25, 26
  38. Afrique LERAS26
  39. Azarpazhooh MR27
  40. Barac A28
  41. Barboza M29, 30
  42. Barkercollo SL31
  43. Barnighausen T32, 33, 34
  44. Farvid MS32, 60
  45. Mohammed S34, 138
  46. Bedi N35
  47. Beghi E36
  48. Giussani G36
  49. Bennett DA37
  50. Hay SI37, 42
  51. Goulart AC38, 66
  52. Santos IS38
  53. Bensenor IM38
  54. Lotufo PA38
  55. Berhane A39
  56. Jeemon P40, 80
  57. Bhaumik S40
  58. Dandona L40, 42
  59. Dandona R40, 42
  60. Kumar GA40
  61. Birlik SM41
  62. Biryukov S42
  63. Casey D42
  64. Foreman KJ42, 62
  65. Goldberg EM42
  66. Khalil IA42
  67. Kyu HH42
  68. Manhertz T42
  69. Mokdad AH42
  70. Naghavi M42
  71. Nguyen G42
  72. Nichols E42
  73. Smith M42
  74. Murray CJL42
  75. Roth GA42
  76. Stanaway JD42
  77. Vos T42
  78. Ellenbogen RG42
  79. Jakovljevic MB42, 78
  80. Tirschwell DL42
  81. Zunt JR42
  82. Boneya DJ43
  83. Hambisa M44
  84. Bulto LNB44
  85. Carabin H45
  86. Castanedaorjuela CA46, 47
  87. Catalalopez F48, 49
  88. Tabaresseisdedos R48
  89. Chen H50
  90. Chitheer AA51
  91. Chowdhury R52
  92. Christensen H53
  93. Deveber GA54
  94. Dharmaratne SD55
  95. Do HP56
  96. Nguyen CT56
  97. Nguyen QL56
  98. Nguyen TH56
  99. Nong VM56
  100. Dokova K57
  101. Dorsey ER58
  102. Eskandarieh S59
  103. Fischer F61
  104. Majeed A62
  105. Steiner TJ62, 193
  106. Rawaf S62
  107. Shakir R62
  108. Shoman H62
  109. Geleijnse JM63
  110. Gillum RF64
  111. Gona PN65
  112. Gugnani HC67
  113. Gupta R68, 69
  114. Hachinski V70
  115. Hamadeh RR71
  116. Hankey GJ72, 73, 74
  117. Hareri HA75
  118. Heydarpour P76
  119. Sahraian MA76
  120. Kasaeian A76
  121. Malekzadeh R76
  122. Roshandel G76, 169
  123. Sepanlou SG76
  124. Hotez PJ77
  125. Javanbakht M79
  126. Jonas JB81
  127. Kalkonde Y82
  128. Kandel A83
  129. Karch A84, 85
  130. Kastor A86
  131. Rahman MHU86, 163
  132. Keiyoro PN87, 88
  133. Khader YS89
  134. Khan EA90
  135. Khang Y91, 92
  136. Khoja ATA93, 94
  137. Tran BX94, 201
  138. Khubchandani J95
  139. Kim D96
  140. Kim YJ97
  141. Kivimaki M98, 99
  142. Kokubo Y100
  143. Kosen S101
  144. Kravchenko M102
  145. Piradov MA102
  146. Varakin YY102
  147. Defo BK103, 104
  148. Kulkarni C103
  149. Kumar R105
  150. Larsson A106
  151. Lavados PM107
  152. Li Y108
  153. Liang X109
  154. Liben ML110
  155. Lo WD111, 112
  156. Logroscino G113
  157. Loy CT114
  158. Mackay MT115, 116
  159. Meretoja A116, 131, 132
  160. Szoeke CEI116, 131
  161. Abd El Razek HM117, 118
  162. Mantovani LG119
  163. Massano J120, 121
  164. Mazidi M122
  165. Mcalinden C123, 124
  166. Mehata S125
  167. Mehndiratta MM126
  168. Memish ZA127, 128
  169. Mendoza W129
  170. Mensah GA130
  171. Wijeratne T131, 216
  172. Miller TR133, 134
  173. Mohamed Ibrahim N136
  174. Mohammadi A137
  175. Moradilakeh M139
  176. Velasquez IM140
  177. Musa KI141
  178. Ngunjiri JW142
  179. Ningrum DNA143, 144
  180. Norrving B145
  181. Stein DJ146, 192
  182. Noubiap JJN146, 147
  183. Ogbo FA148
  184. Renzaho AMN148
  185. Owolabi MO149, 150
  186. Pandian JD151
  187. Parmar PG152
  188. Pereira DM153
  189. Petzold M154, 155
  190. Phillips MR156, 157
  191. Poulton RG158
  192. Pourmalek F159
  193. Qorbani M160
  194. Rafay A161, 162
  195. Rai RK164
  196. Rajsic S165
  197. Ranta A166, 167
  198. Rezai MS168
  199. Rubagotti E170
  200. Sachdev P171, 172
  201. Safiri S173
  202. Sahathevan R174, 175
  203. Samy AM176
  204. Santalucia P177
  205. Sartorius B178, 179
  206. Satpathy M180
  207. Sawhney M181
  208. Saylan MI182
  209. Shaikh MA183
  210. Shamsizadeh M184
  211. Sheth KN185
  212. Shigematsu M186, 187
  213. Silva DAS188
  214. Sobngwi E189, 190
  215. Sposato LA191
  216. Stovner LJ193, 194
  217. Abdulkader RS195
  218. Tanne D196, 197
  219. Thrift AG198
  220. Topormadry R199, 200
  221. Truelsen T202
  222. Ukwaja KN203
  223. Uthman OA204
  224. Vasankari T205
  225. Venketasubramanian N206
  226. Vlassov VV207
  227. Wadilo F208
  228. Wallin MT209, 210
  229. Westerman R214, 215
  230. Wiysonge CS217, 218
  231. Wolfe CD219, 220
  232. Xavier D221
  233. Xu G222
  234. Yano Y223
  235. Yimam HH224
  236. Yonemoto N225
  237. Yu C226
  238. Zaidi Z227
  239. Zaki ME228
Show Affiliations
Authors Affiliations
  1. 1. National Institute for Stroke and Applied Neurosciences, Auckland University of Technology, Auckland, New Zealand
  2. 2. School of Public Health, University of Queensland, Brisbane, QLD, Australia
  3. 3. Department of Epidemiology, College of Health Sciences, Jimma University, Jimma, Ethiopia
  4. 4. Department of Neurology, Cairo University, Cairo, Egypt
  5. 5. New York University Abu Dhabi, Abu Dhabi, United Arab Emirates
  6. 6. School of Public Health, College of Health Sciences, Mekelle University, Mekelle, Ethiopia
  7. 7. School of Public Health, College of Health Sciences, Mekelle University, Mekelle, Ethiopia
  8. 8. Food Security and Institute for Biological Chemistry and Nutrition, University of Hohenheim, Stuttgart, Germany
  9. 9. University Ferhat Abbas of Setif, Setif, Algeria
  10. 10. National Institute of Nursing Education, Setif, Algeria
  11. 11. High National School of Veterinary Medicine, Algiers, Algeria
  12. 12. University of Ibadan, Ibadan, Nigeria
  13. 13. Newcastle University, Newcastle upon Tyne, United Kingdom
  14. 14. University of Sheffield, Sheffield, United Kingdom
  15. 15. Joint Program of Family and Community Medicine, Jeddah, Saudi Arabia
  16. 16. Universidad de Cartagena, Cartagena de Indias, Colombia
  17. 17. School of Medicine, University of Adelaide, Adelaide, SA, Australia
  18. 18. College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, Ethiopia
  19. 19. Health Promotion Research Center, Department of Epidemiology and Biostatistics, Zahedan University of Medical Sciences, Zahedan, Iran
  20. 20. Kabul, Afghanistan
  21. 21. Department of Neurobiology, Care Sciences and Society, Division of Family Medicine and Primary Care, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
  22. 22. School of Health and Social Studies, Dalarna University, Falun, Sweden
  23. 23. Department of Medical Emergency, School of Paramedic, Qom University of Medical Sciences, Qom, Iran
  24. 24. National Institute of Public Health, Cuernavaca, Mexico
  25. 25. Institut de Recherche Clinique du Benin, Cotonou, Benin
  26. 26. Laboratoire d'Etudes et de Recherche-Action en Sante, Parakou, Benin
  27. 27. Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
  28. 28. Faculty of Medicine, University of Belgrade, Belgrade, Serbia
  29. 29. Hospital Dr Rafael A Calderon Guardia, CCSS, San Jose, Costa Rica
  30. 30. Universidad de Costa Rica, San Pedro, Costa Rica
  31. 31. School of Psychology, University of Auckland, Auckland, New Zealand
  32. 32. Department of Global Health and Population, Harvard T H Chan School of Public Health, Department of Nutrition, Harvard T H Chan School of Public Health, Harvard University, Boston, MA, United States
  33. 33. Africa Health Research Institute, Mtubatuba, South Africa
  34. 34. Institute of Public Health, Heidelberg University, Heidelberg, Germany
  35. 35. College of Public Health and Tropical Medicine, Jazan, Saudi Arabia
  36. 36. IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
  37. 37. Nuffield Department of Population Health, Oxford Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, United Kingdom
  38. 38. Center for Clinical and Epidemiological Research Center, Hospital Universitario, Internal Medicine Department, University of Sao Paulo, Sao Paulo, Brazil
  39. 39. College of Health Sciences, Debre Berhan University, Debre Berhan, Ethiopia
  40. 40. Centre for Control of Chronic Conditions, Public Health Foundation of India, Gurugram, India
  41. 41. GBS-CIDP International Foundation, Menemen, Turkey
  42. 42. Institute for Health Metrics and Evaluation, Harborview/UW Medicine, Center for Health Trends and Forecasts, Institute for Health Metrics and Evaluation, University of Washington, Seattle, WA, United States
  43. 43. Department of Public Health, Debre Markos University, Debre Markos, Ethiopia
  44. 44. College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia
  45. 45. Department of Biostatistics and Epidemiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States
  46. 46. Colombian National Health Observatory, Instituto Nacional de Salud, Bogota, Colombia
  47. 47. Epidemiology and Public Health Evaluation Group, Public Health Department, Universidad Nacional de Colombia, Bogota, Colombia
  48. 48. Department of Medicine, University of Valencia, INCLIVA Health Research Institute and CIBERSAM, Valencia, Spain
  49. 49. Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada
  50. 50. Michigan State University, East Lansing, MI, United States
  51. 51. Ministry of Health, Baghdad, Iraq
  52. 52. Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
  53. 53. Bispebjerg University Hospital, Copenhagen, Denmark
  54. 54. The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
  55. 55. Department of Community Medicine, Faculty of Medicine, University of Peradeniya, Peradeniya, Sri Lanka
  56. 56. Institute for Global Health Innovations, Duy Tan University, Da Nang, Viet Nam
  57. 57. Department of Social Medicine, Faculty of Public Health, Medical University-Varna, Varna, Bulgaria
  58. 58. University of Rochester Medical Center, Rochester, NY, United States
  59. 59. Multiple Sclerosis Research Center, Tehran, Iran
  60. 60. Harvard/MGH Center on Genomics, Vulnerable Populations, and Health Disparities, Mongan Institute for Health Policy, Massachusetts General Hospital, Boston, MA, United States
  61. 61. School of Public Health, Bielefeld University, Bielefeld, Germany
  62. 62. Department of Primary Care and Public Health, Division of Brain Sciences, Imperial College London, London, United Kingdom
  63. 63. Division of Human Nutrition, Wageningen University, Wageningen, Netherlands
  64. 64. Howard University, Washington, DC, United States
  65. 65. University of Massachusetts Boston, Boston, MA, United States
  66. 66. Center of Check of Hospital Sirio Libanes, Sao Paulo, Brazil
  67. 67. Departments of Microbiology and Epidemiology & Biostatistics, Saint James School of Medicine, The Quarter, Anguilla
  68. 68. West Virginia Bureau for Public Health, Charleston, WV, United States
  69. 69. Eternal Heart Care Centre and Research Institute, Jaipur, India
  70. 70. Western University, London, ON, Canada
  71. 71. Arabian Gulf University, Manama, Bahrain
  72. 72. School of Medicine and Pharmacology, University of Western Australia, Perth, WA, Australia
  73. 73. Harry Perkins Institute of Medical Research, Nedlands, WA, Australia
  74. 74. Western Australian Neuroscience Research Institute, Nedlands, WA, Australia
  75. 75. Addis Ababa University, Addis Ababa, Ethiopia
  76. 76. Multiple Sclerosis Research Center, Neuroscience Institute, Hematology-Oncology and Stem Cell Transplantation Research Center, Endocrinology and Metabolism Population Sciences Institute, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  77. 77. College of Medicine, Baylor University, Houston, TX, United States
  78. 78. Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia
  79. 79. University of Aberdeen, Aberdeen, United Kingdom
  80. 80. Centre for Chronic Disease Control, New Delhi, India
  81. 81. Department of Ophthalmology, Medical Faculty Mannheim, Ruprecht-Karls-University Heidelberg, Mannheim, Germany
  82. 82. Society for Education, Action and Research in Community Health, Gadchiroli, India
  83. 83. University at Buffalo, Buffalo, NY, United States
  84. 84. Epidemiological and Statistical Methods Research Group, Helmholtz Centre for Infection Research, Braunschweig, Germany
  85. 85. Hannover-Braunschweig Site, German Center for Infection Research, Braunschweig, Germany
  86. 86. International Institute for Population Sciences, Mumbai, India
  87. 87. Institute of Tropical and Infectious Diseases, Nairobi, Kenya
  88. 88. School of Continuing and Distance Education, Nairobi, Kenya
  89. 89. Department of Community Medicine, Public Health and Family Medicine, Jordan University of Science and Technology, Irbid, Jordan
  90. 90. Health Services Academy, Islamabad, Pakistan
  91. 91. Department of Health Policy and Management, Seoul National University College of Medicine, Seoul, South Korea
  92. 92. Institute of Health Policy and Management, Seoul National University Medical Center, Seoul, South Korea
  93. 93. Department of Public Health and Department of Family Medicine, College of Medicine, Mohammed Ibn Saudi University, Riyadh, Saudi Arabia
  94. 94. Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, United States
  95. 95. Department of Nutrition and Health Science, Ball State University, Muncie, IN, United States
  96. 96. Department of Health Sciences, Northeastern University, Boston, MA, United States
  97. 97. School of Medicine, Xiamen University Malaysia Campus, Sepang, Malaysia
  98. 98. Department of Epidemiology and Public Health, University College London, London, United Kingdom
  99. 99. Faculty of Medicine, University of Helsinki, Clinicum, Helsinki, Finland
  100. 100. Department of Preventive Cardiology, National Cerebral and Cardiovascular Center, Suita, Japan
  101. 101. Center for Community Empowerment, Health Policy and Humanities, National Institute of Health Research & Development, Jakarta, Indonesia
  102. 102. Research Center of Neurology, Moscow, Russian Federation
  103. 103. Department of Social and Preventive Medicine, School of Public Health Rajrajeswari Medical College and Hospital, Bangalore, India
  104. 104. Department of Demography and Public Health Research Institute, University of Montreal, Montreal, QC, Canada
  105. 105. King George Medical University, Lucknow, India
  106. 106. Department of Medical Sciences, Uppsala University, Uppsala, Sweden
  107. 107. Servicio de Neurologia, Clinica Alemana, Universidad del Desarrollo, Santiago, Chile
  108. 108. San Francisco VA Medical Center, San Francisco, CA, United States
  109. 109. Chinese Center for Disease Control and Prevention, Beijing, China
  110. 110. Samara University, Samara, Ethiopia
  111. 111. Departments of Pediatrics and Neurology, Ohio State University, Columbus, OH, United States
  112. 112. Nationwide Children's Hospital, Columbus, OH, United States
  113. 113. University of Bari, Bari, Italy
  114. 114. The University of Sydney, Sydney, NSW, Australia
  115. 115. Royal Children's Hospital Melbourne, Melbourne, VIC, Australia
  116. 116. Department of Medicine, Institute of Health and Ageing, University of Melbourne, Melbourne, VIC, Australia
  117. 117. Mansoura Faculty of Medicine, Mansoura, Egypt
  118. 118. Aswan University Hospital, Aswan Faculty of Medicine, Aswan, Egypt
  119. 119. University of Milano Bicocca, Monza, Italy
  120. 120. Hospital Pedro Hispano/ULS Matosinhos, Matosinhos, Portugal
  121. 121. Faculty of Medicine, University of Porto, Porto, Portugal
  122. 122. Key State Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China
  123. 123. University Hospitals Bristol NHS Foundation Trust, Bristol, United Kingdom
  124. 124. Public Health Wales, Swansea, United Kingdom
  125. 125. Ipas Nepal, Kathmandu, Nepal
  126. 126. Janakpuri Superspecialty Hospital, New Delhi, India
  127. 127. Saudi Ministry of Health, Riyadh, Saudi Arabia
  128. 128. College of Medicine, Alfaisal University, Riyadh, Saudi Arabia
  129. 129. United Nations Population Fund, Lima, Peru
  130. 130. Center for Translation Research and Implementation Science, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States
  131. 131. Department of Medicine, Institute of Health and Ageing, University of Melbourne, Footscray, VIC, Australia
  132. 132. Department of Neurology, Helsinki University Hospital, Helsinki, Finland
  133. 133. Pacific Institute for Research & Evaluation, Calverton, MD, United States
  134. 134. Centre for Population Health, Curtin University, Perth, WA, Australia
  135. 135. Nepal Development Society, Chitwan, Nepal
  136. 136. Department of Medicine, Universiti Kebangsaan Malaysia Medical Center, Bandar Tun Razak, Malaysia
  137. 137. Neuroscience Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
  138. 138. Health Systems and Policy Research Unit, Ahmadu Bello University, Zaria, Nigeria
  139. 139. Department of Community Medicine, Preventive Medicine and Public Health Research Center, Gastrointestinal and Liver Disease Research Center, Iran University of Medical Sciences, Tehran, Iran
  140. 140. Gorgas Memorial Institute for Health Studies, Panama City, Panama
  141. 141. School of Medical Sciences, University of Science Malaysia, Kubang Kerian, Malaysia
  142. 142. University of Nairobi, Nairobi, Kenya
  143. 143. Department of Public Health, Semarang State University, Semarang City, Indonesia
  144. 144. Graduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, Taipei City, Taiwan
  145. 145. Skane University Hospital, Department of Clinical Sciences Lund, Neurology, Lund University, Lund, Sweden
  146. 146. Department of Psychiatry, University of Cape Town, Cape Town, South Africa
  147. 147. Medical Diagnostic Centre, Yaounde, Cameroon
  148. 148. Centre for Health Research, Western Sydney University, Penrith, NSW, Australia
  149. 149. Department of Medicine, Ibadan, Nigeria
  150. 150. Blossom Specialist Medical Center, Ibadan, Nigeria
  151. 151. Christian Medical College Ludhiana, Ludhiana, India
  152. 152. Auckland University of Technology, Auckland, New Zealand
  153. 153. REQUIMTE/LAQV, LaboratOrio de Farmacognosia, Departamento de Quimica, Faculdade de Farmacia, Universidade do Porto, Porto, Portugal
  154. 154. Health Metrics Unit, University of Gothenburg, Gothenburg, Sweden
  155. 155. University of the Witwatersrand, Johannesburg, South Africa
  156. 156. Shanghai Jiao Tong University School of Medicine, Shanghai, China
  157. 157. Emory University, Atlanta, GA, United States
  158. 158. University of Otago, Dunedin, New Zealand
  159. 159. University of British Columbia, Vancouver, BC, Canada
  160. 160. Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran
  161. 161. Contech International Health Consultants, Lahore, Pakistan
  162. 162. Contech School of Public Health, Lahore, Pakistan
  163. 163. Research and Evaluation Division, BRAC, Dhaka, Bangladesh
  164. 164. Society for Health and Demographic Surveillance, Suri, India
  165. 165. ERAWEB Program, University for Health Sciences, Medical Informatics and Technology, Hall in Tirol, Austria
  166. 166. Capital & Coast District Health Board, Wellington, New Zealand
  167. 167. University of Otago, Wellington, New Zealand
  168. 168. Mazandaran University of Medical Sciences, Sari, Iran
  169. 169. Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran
  170. 170. Universidad Tecnica del Norte, Ibarra, Ecuador
  171. 171. University of New South Wales, Randwick, NSW, Australia
  172. 172. Prince of Wales Hospital, Randwick, NSW, Australia
  173. 173. Managerial Epidemiology Research Center, Department of Public Health, School of Nursing and Midwifery, Maragheh University of Medical Sciences, Maragheh, Iran
  174. 174. Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia
  175. 175. Ballarat Health Service, Ballarat, VIC, Australia
  176. 176. Faculty of Science, Ain Shams University, Cairo, Egypt
  177. 177. Fondazione IRCCS Ospedale Maggiore Policlinico, Milan, Italy
  178. 178. Public Health Medicine, School of Nursing and Public Health, University of KwaZulu-Natal, Durban, South Africa
  179. 179. UKZN Gastrointestinal Cancer Research Centre, South African Medical Research Council, Durban, South Africa
  180. 180. Centre of Advanced Study in Psychology, Utkal University, Bhubaneswar, India
  181. 181. Department of Public Health, Marshall University, Huntington, WV, United States
  182. 182. Bayer Turkey, Istanbul, Turkey
  183. 183. Independent Consultant, Karachi, Pakistan
  184. 184. Department of Medical Surgical Nursing, School of Nursing and Midwifery, Hamadan University of Medical Sciences, Hamadan, Iran
  185. 185. School of Medicine, Yale University, New Haven, CT, United States
  186. 186. National Institute of Infectious Diseases, Tokyo, Japan
  187. 187. Sandia National Laboratories, Albuquerque, NM, United States
  188. 188. Federal University of Santa Catarina, Florianopolis, Brazil
  189. 189. University of Yaounde, Yaounde, Cameroon
  190. 190. Yaounde Central Hospital, Yaounde, Cameroon
  191. 191. Department of Clinical Neurological Sciences, Western University, London, ON, Canada
  192. 192. South African Medical Research Council Unit on Anxiety & Stress Disorders, Cape Town, South Africa
  193. 193. Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway
  194. 194. Norwegian Advisory Unit on Headache, St. Olavs Hospital, Trondheim, Norway
  195. 195. Ministry of Health, Kingdom of Saudi Arabia, Riyadh, Saudi Arabia
  196. 196. Chaim Sheba Medical Center, Tel Hashomer, Israel
  197. 197. Tel Aviv University, Tel Aviv, Israel
  198. 198. Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Melbourne, VIC, Australia
  199. 199. Institute of Public Health, Faculty of Health Sciences, Jagiellonian University Medical College, Krakow, Poland
  200. 200. Faculty of Health Sciences, Wroclaw Medical University, Wroclaw, Poland
  201. 201. Hanoi Medical University, Hanoi, Viet Nam
  202. 202. Department of Neurology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
  203. 203. Department of Internal Medicine, Federal Teaching Hospital, Abakaliki, Nigeria
  204. 204. Warwick Medical School, University of Warwick, Coventry, United Kingdom
  205. 205. UKK Institute for Health Promotion Research, Tampere, Finland
  206. 206. Raffles Neuroscience Centre, Raffles Hospital, Singapore
  207. 207. National Research University Higher School of Economics, Moscow, Russian Federation
  208. 208. Wolaita Sodo University, Wolaita Sodo, Ethiopia
  209. 209. VA Medical Center, Washington, DC, United States
  210. 210. Neurology Department, Georgetown University, Washington, DC, United States
  211. 211. Department of Research, Cancer Registry of Norway, Institute of Population-Based Cancer Research, Oslo, Norway
  212. 212. Department of Community Medicine, Faculty of Health Sciences, University of Tromso, The Arctic University of Norway, Tromso, Norway
  213. 213. Genetic Epidemiology Group, Folkhalsan Research Center, Helsinki, Finland
  214. 214. Federal Institute for Population Research, Wiesbaden, Germany
  215. 215. German National Cohort Consortium, Heidelberg, Germany
  216. 216. Western Health, Footscray, VIC, Australia
  217. 217. South African Medical Research Council, Cochrane South Africa, Cape Town, South Africa
  218. 218. Stellenbosch University, Cape Town, South Africa
  219. 219. Division of Health and Social Care Research, King's College London, London, United Kingdom
  220. 220. National Institute for Health Research Comprehensive Biomedical Research Centre, Guy's & St Thomas' NHS Foundation Trust and King's College London, London, United Kingdom
  221. 221. St. John's Medical College and Research Institute, Bangalore, India
  222. 222. Department of Neurology, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China
  223. 223. Department of Preventive Medicine, Northwestern University, Chicago, IL, United States
  224. 224. Mizan Tepi University, Mizan Teferi, Ethiopia
  225. 225. Department of Biostatistics, School of Public Health, Kyoto University, Kyoto, Japan
  226. 226. Department of Epidemiology and Biostatistics, School of Public Health, Global Health Institute, Wuhan University, Wuhan, China
  227. 227. University Hospital of Setif, Setif, Algeria
  228. 228. Faculty of Medicine, Mansoura University, Mansoura, Egypt

Source: The Lancet Neurology Published:2017


Abstract

Background Comparable data on the global and country-specific burden of neurological disorders and their trends are crucial for health-care planning and resource allocation. The Global Burden of Diseases, Injuries, and Risk Factors (GBD) Study provides such information but does not routinely aggregate results that are of interest to clinicians specialising in neurological conditions. In this systematic analysis, we quantified the global disease burden due to neurological disorders in 2015 and its relationship with country development level. Methods We estimated global and country-specific prevalence, mortality, disability-adjusted life-years (DALYs), years of life lost (YLLs), and years lived with disability (YLDs) for various neurological disorders that in the GBD classification have been previously spread across multiple disease groupings. The more inclusive grouping of neurological disorders included stroke, meningitis, encephalitis, tetanus, Alzheimer's disease and other dementias, Parkinson's disease, epilepsy, multiple sclerosis, motor neuron disease, migraine, tension-type headache, medication overuse headache, brain and nervous system cancers, and a residual category of other neurological disorders. We also analysed results based on the Socio-demographic Index (SDI), a compound measure of income per capita, education, and fertility, to identify patterns associated with development and how countries fare against expected outcomes relative to their level of development. Findings Neurological disorders ranked as the leading cause group of DALYs in 2015 (250·7 [95% uncertainty interval (UI) 229·1 to 274·7] million, comprising 10·2% of global DALYs) and the second-leading cause group of deaths (9·4 [9·1 to 9·7] million], comprising 16·8% of global deaths). The most prevalent neurological disorders were tension-type headache (1505·9 [UI 1337·3 to 1681·6 million cases]), migraine (958·8 [872·1 to 1055·6] million), medication overuse headache (58·5 [50·8 to 67·4 million]), and Alzheimer's disease and other dementias (46·0 [40·2 to 52·7 million]). Between 1990 and 2015, the number of deaths from neurological disorders increased by 36·7%, and the number of DALYs by 7·4%. These increases occurred despite decreases in age-standardised rates of death and DALYs of 26·1% and 29·7%, respectively; stroke and communicable neurological disorders were responsible for most of these decreases. Communicable neurological disorders were the largest cause of DALYs in countries with low SDI. Stroke rates were highest at middle levels of SDI and lowest at the highest SDI. Most of the changes in DALY rates of neurological disorders with development were driven by changes in YLLs. Interpretation Neurological disorders are an important cause of disability and death worldwide. Globally, the burden of neurological disorders has increased substantially over the past 25 years because of expanding population numbers and ageing, despite substantial decreases in mortality rates from stroke and communicable neurological disorders. The number of patients who will need care by clinicians with expertise in neurological conditions will continue to grow in coming decades. Policy makers and health-care providers should be aware of these trends to provide adequate services. Funding Bill & Melinda Gates Foundation. © 2017 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC-BY 4.0 license
Experts (# of related papers)
Other Related Docs
34. The Global Burden of Cancer 2013, JAMA Oncology (2015)
36. National and Subnational Burden of Stroke in Iran From 1990 to 2019, Annals of Clinical and Translational Neurology (2022)
38. Tension-Type Headache, Nature Reviews Disease Primers (2021)