A Comparison Effects of L-Citrulline and L-Arginine Against Cyclosporine-Induced Blood Pressure and Biochemical Changes in the Rats; [Comparacion De Los Efectos De L-Citrulina Y L-Arginina Frente a La Presion Arterial Inducida Por Ciclosporina Y Los Cambios Bioquimicos En Ratas] Publisher Pubmed



Hashemi SR¹ ; Arab HA¹ ; Seifi B² ; Muhammadnejad S³ Show Affiliations
Source: Hipertension y Riesgo Vascular Published:2021

Abstract

Objective: The use of cyclosporine A (CsA) is associated with different adverse effects including hypertension and nephrotoxicity. The present study aimed to compare the inhibitory effects of L-arginine & L-citrulline on CsA-induced blood pressure and biochemical changes in the serum of rats. Methods: Thirty-six rats were divided into 6 groups received daily: (1) 1 ml distilled water, (2) 200 mg/kg L-citrulline IP, (3) 25 mg/kg CsA SC, (4) CsA + L-citrulline with the same dose of the former groups, (5) 200 mg/kg L-arginine IP and (6) L-arginie+CsA with the same doses of group 4 for 7 days. Results: The changes in the blood pressure, heart rate, creatinine, BUN, glucose and C-reactive protein (CRP) of the serum were determined in the treated animals. Significant (p < 0.001) increase was shown in the blood pressure and heart rate of CsA treated rats compared to the control group. There were also a significant (p < 0.05) increase in the creatinine, BUN and glucose, but a decrease in the CRP value in the CsA-treated group. However, L-citrulline significantly (p < 0.001) inhibited the changes in the blood pressure and heart rate in CsA-treated as well as it was able to reduce blood pressure in non-treated group significantly (p < 0.01). L-citrulline also inhibited the increased levels of BUN and creatinine induced by CsA, while, L-arginine was able to prevent the increased blood pressure and creatinine occurs after administration of CsA. Conclusions: These findings suggest that the L-citrulline is more efficient than L-arginine against the adverse effects induced by cyclosporine. © 2021