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Mirna-Binding Site Polymorphism In Il-15Ra Gene in Rheumatoid Arthritis and Systemic Lupus Erythematosus: Correlation With Disease Risk and Clinical Characteristics Publisher Pubmed



Jadidi N1, 2 ; Alesaeidi S3 ; Arab F4 ; Pakzad B5 ; Siasi E1 ; Esmaeilzadeh E6, 7
Authors
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Authors Affiliations
  1. 1. Department of Genetics, Faculty of Basic Sciences, North Tehran Branch, Islamic Azad University, Tehran, Iran
  2. 2. Department of Biology, Faculty of Basic Sciences, North Tehran Branch, Islamic Azad University, Tehran, Iran
  3. 3. Rheumatology and Internal Medicine, Rheumatology Research Center, Amir-Alam Hospital, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Medical Genetics, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Division of Rheumatology, Department of Internal Medicine, School of Medicine, Isfahan University of Medical Science, Isfahan, Iran
  6. 6. Personalized Medicine and Genometabolomics Research Center, Hope Generation Foundation, Tehran, Iran
  7. 7. Fetal Health Research Center, Hope Generation Foundation, Tehran, Iran

Source: Clinical Rheumatology Published:2022


Abstract

Introduction/objectives: MiRSNPs may interfere with mRNA stability through effects on microRNAs (miRNAs)-mRNA interactions via direct changes in miRNA binding site or effect on the secondary structure of this region and changes in accessibility of this region to miRNAs. Studies have confirmed that an elevated level of interleukin-15 receptor alpha (IL-15RA) has an important role in the pathogenesis of systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). In the present study, for the first time, we aimed to evaluate the possible correlation between a miRSNP, rs2296135, in IL-15RA gene with the risk of SLE and RA. Methods: In this case–control study, 100 SLE patients, 100 RA patients, and 110 healthy participants were enrolled to assess rs2296135 genotypes with real-time PCR high-resolution melting method. Results: According to our findings, AA genotype and A allele of rs2296135 were considerably associated with enhanced risk of RA (for AA genotype, OR = 2.29; 95% CI [1.06–5.02]; for A allele, OR = 1.65; 95% CI [1.10–2.48]). However, this common variant was not significantly correlated with SLE risk in population under study. Stratification analysis in the RA group verified that patients with the A allele had considerably higher serum concentrations of C-reactive protein (CRP) (P < 0.001). In SLE subjects, the frequency of arthritis (P: 0.021) and renal involvement (P: 0.025) in patients with A allele was significantly higher than in other SLE individuals. Conclusion: The current study proposes a substantial association between rs2296135 polymorphism in IL-15RA gene with augmented risk of RA and some clinical characteristics in RA and SLE patients. © 2022, The Author(s), under exclusive licence to International League of Associations for Rheumatology (ILAR).
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