Ethical Considerations in Conducting Clinical Trials Publisher



Mousavinejad S¹ ; Bazmi S¹ ; Rezaeitavirani M² ; Shamsigooshki E³ ; Enjoo SA¹ ; Kiani M¹ Show Affiliations
Source: International Journal of Medical Toxicology and Forensic Medicine Published:2021

Abstract

Background: Clinical trials are the golden key in medical science research with human participants. They have always been considered interesting topics by researchers and scientists working in this field. However, the samples are human participants, so the research should be carefully conducted. Methods: In the present study, the published articles on the ethical challenges of conducting clinical trials were evaluated between 2010 and 2019 in Google Scholar, PubMed, and Scopus. The English search keywords were clinical trial, with at least one of the phrases of ethical consideration or standard. Results: In this article, we examined the ethical requirements and considerations in these research studies in four stages: research design and question, proposal review and approval, supervision and implementation, and publication of the results. We have examined them using relevant articles published between 2010 and 2019 and identified important and prominent issues or neglected ones. Conclusion: During this study, it was found that the research design and question stage was the most discussed and challenging stage, and the authors' sensitivity about it has been more than the other three stages. On the other hand, the results publishing stage has been considered less sensitive with the least number of references in articles. © 2021 Shahid Beheshti University of Medical Sciences. All rights reserved.